Occult Multiple Arterial Occlusions in Behçet’s Disease Manifesting as Posterior Reversible Encephalopathy Syndrome Secondary to Renovascular Hypertension
Abstract
Behçet's disease is a systemic vasculitis that can cause life-threatening complications. We report the case of a 28-year-old man with Behçet's disease who developed severe hypertension and generalized seizures. Imaging revealed concurrent complete occlusions of the left renal and common carotid arteries, with segmental infarction of the right kidney. Renal vasculature involvement caused marked hyperreninemia and renovascular hypertension, subsequently triggering posterior reversible encephalopathy syndrome. Treatment with high-dose glucocorticoids, cyclophosphamide, and strict blood pressure control resulted in clinical and neuroimaging resolution. This case illustrates that Behçet's disease can manifest as occult, multivessel arterial occlusions. Early systemic vascular screening and prompt immunosuppression are pivotal for preventing irreversible complications.
Related
- Clinicopathological Review of Renovascular Hypertension and Hypertensive Emergency-related Nephropathy Based on Case Series
- Renovascular hypertension drives ischemic white matter injury via brain endothelial AT1R signaling
- Clinical and radiological features of posterior reversible encephalopathy syndrome in children: a retrospective study
- Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal Anti-inflammatory Drugs
- Legionella-Associated Encephalopathy With a Reversible Splenial Lesion and Additional Reversible Cortical and White Matter Lesions.
BibTeX
@article{kawabata2026occult,
title = {{Occult Multiple Arterial Occlusions in Behçet’s Disease Manifesting as Posterior Reversible Encephalopathy Syndrome Secondary to Renovascular Hypertension}},
author = {Marisa Kawabata and Shuhei Mitsunaga and Tetsuro Sekine and Hajime Yoshifuji and Mitsuhiro Takeno},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7916-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7916-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Occult Multiple Arterial Occlusions in Behçet’s Disease Manifesting as Posterior Reversible Encephalopathy Syndrome Secondary to Renovascular Hypertension
AU - Marisa Kawabata
AU - Shuhei Mitsunaga
AU - Tetsuro Sekine
AU - Hajime Yoshifuji
AU - Mitsuhiro Takeno
PY - 2026
DA - 2026/09/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.7916-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7916-26/_article
AB - Behçet's disease is a systemic vasculitis that can cause life-threatening complications. We report the case of a 28-year-old man with Behçet's disease who developed severe hypertension and generalized seizures. Imaging revealed concurrent complete occlusions of the left renal and common carotid arteries, with segmental infarction of the right kidney. Renal vasculature involvement caused marked hyperreninemia and renovascular hypertension, subsequently triggering posterior reversible encephalopathy syndrome. Treatment with high-dose glucocorticoids, cyclophosphamide, and strict blood pressure control resulted in clinical and neuroimaging resolution. This case illustrates that Behçet's disease can manifest as occult, multivessel arterial occlusions. Early systemic vascular screening and prompt immunosuppression are pivotal for preventing irreversible complications.
SN - 1349-7235
SN - 0918-2918
ER -