Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal…

Abstract

Scleroderma renal crisis (SRC) and posterior reversible encephalopathy syndrome (PRES) are rare but severe complications of systemic sclerosis (SSc). We report the case of a 44-year-old patient with SSc who developed SRC and PRES, potentially triggered by non-steroidal anti-inflammatory drugs (NSAIDs). The patient presented with impaired consciousness, renal dysfunction, hemolytic anemia, thrombocytopenia, and occipital white matter lesions on magnetic resonance imaging. Treatment included enalapril, hemodialysis, and plasma exchange. This case highlights the potential role of NSAIDs in the development of SRC, and emphasizes the importance of considering NSAIDs as a significant risk factor for SRC in patients with SSc.

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Cite

BibTeX RIS

BibTeX

@article{suzuki2026scleroderma,
  title = {{Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal Anti-inflammatory Drugs}},
  author = {Takaya Suzuki and Mai Ishikawa and Takuya Yamaguchi and Masahiro Miyata and Takaaki Nawano and Yukino Yokokawa and Soichiro Kon and Eri Matsuki and Sayumi Watanabe and Keita Kamei and Kazunobu Ichikawa and Masafumi Watanabe},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.5836-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5836-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal Anti-inflammatory Drugs
AU  - Takaya Suzuki
AU  - Mai Ishikawa
AU  - Takuya Yamaguchi
AU  - Masahiro Miyata
AU  - Takaaki Nawano
AU  - Yukino Yokokawa
AU  - Soichiro Kon
AU  - Eri Matsuki
AU  - Sayumi Watanabe
AU  - Keita Kamei
AU  - Kazunobu Ichikawa
AU  - Masafumi Watanabe
PY  - 2026
DA  - 2026/08/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.5836-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5836-25/_article
AB  - Scleroderma renal crisis (SRC) and posterior reversible encephalopathy syndrome (PRES) are rare but severe complications of systemic sclerosis (SSc). We report the case of a 44-year-old patient with SSc who developed SRC and PRES, potentially triggered by non-steroidal anti-inflammatory drugs (NSAIDs). The patient presented with impaired consciousness, renal dysfunction, hemolytic anemia, thrombocytopenia, and occipital white matter lesions on magnetic resonance imaging. Treatment included enalapril, hemodialysis, and plasma exchange. This case highlights the potential role of NSAIDs in the development of SRC, and emphasizes the importance of considering NSAIDs as a significant risk factor for SRC in patients with SSc.
SN  - 1349-7235
SN  - 0918-2918
ER  -