Mid-term clinical and radiologic outcomes of augmented microfracture with decellularized particulated costal allocartilage for knee cartilage defects: four-year prospective case series
- 1Arthroscopy and Joint Research Institute, Yonsei University College of Medicine
- 2Department of Orthopaedic Surgery, Anam Hospital, Korea University College of Medicine
- 3Department of Orthopaedic Surgery, National Health Insurance Service Ilsan Hospital
Abstract
Augmented microfracture using decellularized particulated costal allocartilage has shown favorable short-term outcomes for knee cartilage defects, but evidence regarding its durability beyond 2 years remains limited. We aimed to evaluate the mid-term structural and clinical outcomes following augmented microfracture using decellularized particulated costal allocartilage. This prospective longitudinal single-arm study included 40 patients from the intervention arm of a previously conducted randomized controlled trial who were treated with augmented microfracture using decellularized particulated costal allocartilage. Magnetic resonance imaging (MRI) outcomes were assessed using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system at 1, 2, 3, and 4 years postoperatively. Patient-reported outcome measures (PROMs), including the Knee Injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee score, and pain measured using a visual analog scale, were collected at baseline and at 1, 2, and 4 years. The mean MOCART total score peaked at 2 years (58.3 ± 10.3) and declined modestly thereafter, with 4-year scores (54.2 ± 14.2) remaining comparable to those at 1 and 3 years but significantly lower than those at 2 years (p = 0.035). All PROMs improved significantly from baseline (all p < 0.001). KOOS total, symptom, and quality-of-life subscores continued to improve from 1 to 4 years (p = 0.020, p = 0.006, and p = 0.048, respectively), while other subscores plateaued. Augmented microfracture using decellularized particulated costal allocartilage demonstrated MRI-assessed repair tissue quality that remained comparable at 1, 3, and 4 years despite a transient peak at 2 years, while clinical improvement was sustained through 4 years.
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BibTeX
@article{chung2026midterm,
title = {{Mid-term clinical and radiologic outcomes of augmented microfracture with decellularized particulated costal allocartilage for knee cartilage defects: four-year prospective case series}},
author = {Kwangho Chung and Min Jung and Ki-Mo Jang and Sanghoon Park and Sung-Hwan Kim},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-63052-7},
url = {https://doi.org/10.1038/s41598-026-63052-7},
note = {CC BY},
}
RIS
TY - JOUR
TI - Mid-term clinical and radiologic outcomes of augmented microfracture with decellularized particulated costal allocartilage for knee cartilage defects: four-year prospective case series
AU - Kwangho Chung
AU - Min Jung
AU - Ki-Mo Jang
AU - Sanghoon Park
AU - Sung-Hwan Kim
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-63052-7
UR - https://doi.org/10.1038/s41598-026-63052-7
AB - Augmented microfracture using decellularized particulated costal allocartilage has shown favorable short-term outcomes for knee cartilage defects, but evidence regarding its durability beyond 2 years remains limited. We aimed to evaluate the mid-term structural and clinical outcomes following augmented microfracture using decellularized particulated costal allocartilage. This prospective longitudinal single-arm study included 40 patients from the intervention arm of a previously conducted randomized controlled trial who were treated with augmented microfracture using decellularized particulated costal allocartilage. Magnetic resonance imaging (MRI) outcomes were assessed using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system at 1, 2, 3, and 4 years postoperatively. Patient-reported outcome measures (PROMs), including the Knee Injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee score, and pain measured using a visual analog scale, were collected at baseline and at 1, 2, and 4 years. The mean MOCART total score peaked at 2 years (58.3 ± 10.3) and declined modestly thereafter, with 4-year scores (54.2 ± 14.2) remaining comparable to those at 1 and 3 years but significantly lower than those at 2 years (p = 0.035). All PROMs improved significantly from baseline (all p < 0.001). KOOS total, symptom, and quality-of-life subscores continued to improve from 1 to 4 years (p = 0.020, p = 0.006, and p = 0.048, respectively), while other subscores plateaued. Augmented microfracture using decellularized particulated costal allocartilage demonstrated MRI-assessed repair tissue quality that remained comparable at 1, 3, and 4 years despite a transient peak at 2 years, while clinical improvement was sustained through 4 years.
SN - 2045-2322
ER -