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Peer-reviewedCC BY 4.0Reviews in Cardiovascular Medicine

Associations of the Triglyceride-Glucose Index With the Risk of Hypertension and Prehypertension

  • Yue Jiang1
  • Qi Qi2,3
  • Xinyu Wu2,3
  • Lei Li2
  • Chunhui Yin2
  • Cangtuo Li4
  • Bocheng Yue2
  • Quanle Han2
  • Shouling Wu5
  • Kangbo Li6
6 affiliations
  1. 1Catheterization Unit, Tangshan Gongren Hospital, 063000 Tangshan, Hebei, China
  2. 2Department of Cardiology, Tangshan Gongren Hospital, 063000 Tangshan, Hebei, China
  3. 3Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, China
  4. 4Department of Vascular and Interventional Radiology, Tangshan Gongren Hospital, 063000 Tangshan, Hebei, China
  5. 5Department of Cardiology, Kailuan General Hospital, 063000 Tangshan, Hebei, China
  6. 6School of Clinical Medicine, North China University of Science and Technology, 063210 Tangshan, Hebei, China
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Abstract

Background:: This study aimed to explore the associations between the triglyceride-glucose (TyG) index and the risk of developing hypertension and prehypertension in a Chinese population from North China.

Methods:: This study included two sub-studies. Sub-study 1 examined the association between the TyG index and the risk of hypertension. A total of 101,510 participants (81,110 men and 20,400 women, aged 18–98 years) were enrolled in the Kailuan study. Of these, 44,655 individuals with a history of hypertension were excluded, and 56,855 subjects were included in the analysis. Sub-study 2 aimed to examine the association between the TyG index and the risk of prehypertension. A total of 44,655 individuals with a history of hypertension and 35,777 individuals with a history of prehypertension were excluded, leaving 21,078 subjects for analysis. Participants were categorized into four groups (quartiles 1–4) based on the associated baseline TyG index. Cox proportional hazards regression and restricted cubic spline analyses were used to investigate the association between the TyG index and the risk of hypertension and prehypertension.

Results:: In sub-study 1, during a median follow-up of 13.94 years, 5825 incident cases of hypertension were reported. Compared with the first quartile, the fourth quartile had the highest hazard ratio (HR) for incident hypertension (HR: 1.352; 95% confidence interval (CI): 1.241–1.473). In sub-study 2, during a median follow-up of 3.97 years, 16,982 incident cases of prehypertension were reported. Compared with the first quartile, the fourth quartile had the highest HR for incident prehypertension (HR: 1.148; 95% CI: 1.092–1.207).

Conclusions:: These findings indicate that an elevated TyG index is associated with an increased risk of hypertension and prehypertension.

Clinical Trial Registration:: ChiCTR-TNRC-11001489, https://www.chictr.org.cn/showproj.html?proj=8050.

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Cite

BibTeXRIS
BibTeX
@article{jiang2026associations,
  title = {{Associations of the Triglyceride-Glucose Index With the Risk of Hypertension and Prehypertension}},
  author = {Yue Jiang and Qi Qi and Xinyu Wu and Lei Li and Chunhui Yin and Cangtuo Li and Bocheng Yue and Quanle Han and Shouling Wu and Kangbo Li},
  journal = {Reviews in Cardiovascular Medicine},
  year = {2026},
  month = oct,
  doi = {10.31083/rcm47640},
  url = {https://doi.org/10.31083/rcm47640},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Associations of the Triglyceride-Glucose Index With the Risk of Hypertension and Prehypertension
AU  - Yue Jiang
AU  - Qi Qi
AU  - Xinyu Wu
AU  - Lei Li
AU  - Chunhui Yin
AU  - Cangtuo Li
AU  - Bocheng Yue
AU  - Quanle Han
AU  - Shouling Wu
AU  - Kangbo Li
PY  - 2026
DA  - 2026/10/14
JO  - Reviews in Cardiovascular Medicine
DO  - 10.31083/rcm47640
UR  - https://doi.org/10.31083/rcm47640
AB  - Background:: This study aimed to explore the associations between the triglyceride-glucose (TyG) index and the risk of developing hypertension and prehypertension in a Chinese population from North China.  Methods:: This study included two sub-studies. Sub-study 1 examined the association between the TyG index and the risk of hypertension. A total of 101,510 participants (81,110 men and 20,400 women, aged 18–98 years) were enrolled in the Kailuan study. Of these, 44,655 individuals with a history of hypertension were excluded, and 56,855 subjects were included in the analysis. Sub-study 2 aimed to examine the association between the TyG index and the risk of prehypertension. A total of 44,655 individuals with a history of hypertension and 35,777 individuals with a history of prehypertension were excluded, leaving 21,078 subjects for analysis. Participants were categorized into four groups (quartiles 1–4) based on the associated baseline TyG index. Cox proportional hazards regression and restricted cubic spline analyses were used to investigate the association between the TyG index and the risk of hypertension and prehypertension.  Results:: In sub-study 1, during a median follow-up of 13.94 years, 5825 incident cases of hypertension were reported. Compared with the first quartile, the fourth quartile had the highest hazard ratio (HR) for incident hypertension (HR: 1.352; 95% confidence interval (CI): 1.241–1.473). In sub-study 2, during a median follow-up of 3.97 years, 16,982 incident cases of prehypertension were reported. Compared with the first quartile, the fourth quartile had the highest HR for incident prehypertension (HR: 1.148; 95% CI: 1.092–1.207).  Conclusions:: These findings indicate that an elevated TyG index is associated with an increased risk of hypertension and prehypertension.  Clinical Trial Registration:: ChiCTR-TNRC-11001489, https://www.chictr.org.cn/showproj.html?proj=8050.
SN  - 1530-6550
SN  - 2153-8174
ER  -