Associations of the Baseline Level and Change in Triglyceride Glucose-Body Roundness Index With Cardiovascular Diseases: Two Large Prospective Cohorts in Europe and Asia.
- 1Department of Public Health and Preventive Medicine, Public Health Research Center, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.
- 2Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Abstract
The aim of this study was to investigate the association of baseline and changes of TyG-BRI with incident CVD based on the UK Biobank and China Health and Retirement Longitudinal Study (CHARLS). A total of 418,510 and 7923 individuals from the UK Biobank and CHARLS were included in Analysis 1 (baseline TyG-BRI with CVD risk). In Analysis 2 (change in TyG-BRI with CVD risk), a total of 11,682 and 4637 participants were included in Cox proportional hazard models. We found participants with the highest baseline TyG-BRI level were associated with increased risk of incident CVD in UK Biobank (HR = 1.45, 95% CI: 1.39-1.52) and CHARLS (HR = 1.35, 95% CI: 1.13-1.61). Multivariable-adjusted restricted cubic spline analyses presented positive linear associations between TyG-BRI and CVD risk. Compared to persistently low levels of TyG-BRI (Class 1), those with persistently high levels (Class 3: 1.23 (1.02-1.49) and 1.42 (1.11-1.55); Class 4: 1.48 (1.17-1.87) and 1.45 (1.16-2.28); Class 5: 2.58 (1.86-3.58) and 1.63 (1.16-2.28) for UK Biobank and CHARLS) in follow-up were associated with increased risks of incident CVD. In conclusion, a high baseline TyG-BRI level and different changes in TyG-BRI level are associated with increased risks of incident CVD.
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BibTeX
@article{han2026associations,
title = {{Associations of the Baseline Level and Change in Triglyceride Glucose-Body Roundness Index With Cardiovascular Diseases: Two Large Prospective Cohorts in Europe and Asia.}},
author = {Wen-Yang Han and Yi-Qun Li and Pin-Ni Yang and Yi-Ming Jia and Lu-Lu Sun and Rui-Rui Wang and Meng-Yao Shi and Xiao-Wei Zheng and Yong-Hong Zhang and Zheng-Bao Zhu},
journal = {The Kaohsiung journal of medical sciences},
year = {2026},
month = oct,
doi = {10.1002/kjm2.70305},
url = {https://europepmc.org/article/MED/42910548},
note = {CC BY},
}
RIS
TY - JOUR
TI - Associations of the Baseline Level and Change in Triglyceride Glucose-Body Roundness Index With Cardiovascular Diseases: Two Large Prospective Cohorts in Europe and Asia.
AU - Wen-Yang Han
AU - Yi-Qun Li
AU - Pin-Ni Yang
AU - Yi-Ming Jia
AU - Lu-Lu Sun
AU - Rui-Rui Wang
AU - Meng-Yao Shi
AU - Xiao-Wei Zheng
AU - Yong-Hong Zhang
AU - Zheng-Bao Zhu
PY - 2026
DA - 2026/10/22
JO - The Kaohsiung journal of medical sciences
DO - 10.1002/kjm2.70305
UR - https://europepmc.org/article/MED/42910548
AB - The aim of this study was to investigate the association of baseline and changes of TyG-BRI with incident CVD based on the UK Biobank and China Health and Retirement Longitudinal Study (CHARLS). A total of 418,510 and 7923 individuals from the UK Biobank and CHARLS were included in Analysis 1 (baseline TyG-BRI with CVD risk). In Analysis 2 (change in TyG-BRI with CVD risk), a total of 11,682 and 4637 participants were included in Cox proportional hazard models. We found participants with the highest baseline TyG-BRI level were associated with increased risk of incident CVD in UK Biobank (HR = 1.45, 95% CI: 1.39-1.52) and CHARLS (HR = 1.35, 95% CI: 1.13-1.61). Multivariable-adjusted restricted cubic spline analyses presented positive linear associations between TyG-BRI and CVD risk. Compared to persistently low levels of TyG-BRI (Class 1), those with persistently high levels (Class 3: 1.23 (1.02-1.49) and 1.42 (1.11-1.55); Class 4: 1.48 (1.17-1.87) and 1.45 (1.16-2.28); Class 5: 2.58 (1.86-3.58) and 1.63 (1.16-2.28) for UK Biobank and CHARLS) in follow-up were associated with increased risks of incident CVD. In conclusion, a high baseline TyG-BRI level and different changes in TyG-BRI level are associated with increased risks of incident CVD.
SN - 1607-551X
SN - 2410-8650
ER -