Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Harnessing Immunological Properties
- 1College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University Incheon 21936 Republic of Korea
Abstract
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease triggered by damage to the central nervous system (CNS). This CNS damage is caused by the attack of autoreactive T cells against the myelin sheath. Genetic and environmental factors contribute to the development of MS, and the condition causes serious disabilities and exerts substantial health burdens. Although various disease-modifying agents have been developed, they have critical limitations; hence, effective interventions are required. In this context, cell transplantation therapy using mesenchymal stem cells (MSCs), hematopoietic stem cells, neural precursors, neural stem cells, and induced pluripotent stem cells is considered a feasible alternative therapeutic approach. MSCs are adult stem cells that differentiate into multiple lineages and exert immunomodulatory, neuroprotective, and neuroregenerative effects. Therefore, MSCs are considered a promising treatment option for MS owing to their ease of isolation and low immunogenicity. This review summarizes the potential therapeutic benefits of the latest MSC-based approaches for MS treatment in animal models and humans. Furthermore, the review discusses the immunological role of MSCs and future directions for their applications.
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BibTeX
@article{an2026mesenchymal,
title = {{Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Harnessing Immunological Properties}},
author = {Jungeun An and Dongeun Lee and Ji Min Baek and Min Jeong Park and Ye Won Lee and Hye Eum Kim and Kyung Hee Choi and Sung Jean Park and Hee-Sook Jun and Donghee Kim and Ji Woong Choi},
journal = {Biomolecules \& Therapeutics},
year = {2026},
month = nov,
doi = {10.4062/biomolther.2026.141},
url = {https://doi.org/10.4062/biomolther.2026.141},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Harnessing Immunological Properties
AU - Jungeun An
AU - Dongeun Lee
AU - Ji Min Baek
AU - Min Jeong Park
AU - Ye Won Lee
AU - Hye Eum Kim
AU - Kyung Hee Choi
AU - Sung Jean Park
AU - Hee-Sook Jun
AU - Donghee Kim
AU - Ji Woong Choi
PY - 2026
DA - 2026/11/01
JO - Biomolecules & Therapeutics
DO - 10.4062/biomolther.2026.141
UR - https://doi.org/10.4062/biomolther.2026.141
AB - Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease triggered by damage to the central nervous system (CNS). This CNS damage is caused by the attack of autoreactive T cells against the myelin sheath. Genetic and environmental factors contribute to the development of MS, and the condition causes serious disabilities and exerts substantial health burdens. Although various disease-modifying agents have been developed, they have critical limitations; hence, effective interventions are required. In this context, cell transplantation therapy using mesenchymal stem cells (MSCs), hematopoietic stem cells, neural precursors, neural stem cells, and induced pluripotent stem cells is considered a feasible alternative therapeutic approach. MSCs are adult stem cells that differentiate into multiple lineages and exert immunomodulatory, neuroprotective, and neuroregenerative effects. Therefore, MSCs are considered a promising treatment option for MS owing to their ease of isolation and low immunogenicity. This review summarizes the potential therapeutic benefits of the latest MSC-based approaches for MS treatment in animal models and humans. Furthermore, the review discusses the immunological role of MSCs and future directions for their applications.
SN - 1976-9148
SN - 2005-4483
ER -