Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 12 min ago
Peer-reviewedCC BY-NC-NDACS bio & med chem Au

Chemically Induced Proximity in Biological Modulation.

  • Xiaokang Jin1
  • Chen Zhou1
  • Xiaoyu Zhang1,2,3,4,5
5 affiliations
  1. 1Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
  2. 2Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
  3. 3Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, United States.
  4. 4Center for Human Immunobiology, Northwestern University, Chicago, Illinois 60611, United States.
  5. 5International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.
Read full textPDFDOICite

Abstract

Proximity is a fundamental prerequisite for a diverse range of biological processes. Chemically induced proximity strategies exploit this principle to achieve the controllable modulation of targets of interest through programmable biomolecular interactions. By rewiring biological interactions, induced-proximity technologies can regulate protein stability, activity, localization, transcription, and signaling. Recent advances have greatly expanded the repertoire of recruitable effector proteins, enabling the manipulation of challenging targets previously considered intractable. In this review, we summarize the conceptual evolution and mechanistic diversity of induced-proximity technologies, highlighting platforms for targeted protein degradation, stabilization, post-translational modification editing, protein relocalization, and transcriptional control.

Related

  1. Chemically Induced Proximity for Targeted Protein O-GlcNAcylation.
    Bowen Ma, Tongyang Xu, Zhihao Guo +1
    Accounts of chemical researchPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC
  2. A Chemically Characterized Polyherbal Extract Selectively Attenuates Chronic Unpredictable Stress-Induced Redox-Sensitive, Inflammatory, and Metabolic Alterations in Female Rats
    Sanja Kovačević, Ljupka Gligorovska, Biljana Bursać +8
    International Journal of Molecular SciencesPeer-reviewedCC BY 4.0Molecular biology & gene regulationCrossref
  3. The Intersection of Allostery and Induced Proximity through the E3 Ligase Cereblon
    Vanessa N. Dippon, Christina M. Woo
    ACS Central SciencePeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationCrossref
  4. Terahertz Modulation of Biomolecular Dynamics: Physical Mechanisms, Biological Implications, and Future Challenges.
    Xingrong Li, Zhihao Chen, Kang Ru +10
    Research (Washington, D.C.)Peer-reviewedCC BYFull textBiophysicsEurope PMC
  5. Retinal organoid–based evaluation of icariin-loaded extracellular vesicles for hypoxia-induced retinal injury via mitochondrial modulation
    Mira Park, Hyeoun Ji Kim, Yoon-Ha Go +5
    Frontiers in cell and developmental biologyPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC

Cite

BibTeXRIS
BibTeX
@article{jin2026chemically,
  title = {{Chemically Induced Proximity in Biological Modulation.}},
  author = {Xiaokang Jin and Chen Zhou and Xiaoyu Zhang},
  journal = {ACS bio \& med chem Au},
  year = {2026},
  month = aug,
  doi = {10.1021/acsbiomedchemau.6c00121},
  url = {https://europepmc.org/article/MED/42921024},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Chemically Induced Proximity in Biological Modulation.
AU  - Xiaokang Jin
AU  - Chen Zhou
AU  - Xiaoyu Zhang
PY  - 2026
DA  - 2026/08/24
JO  - ACS bio & med chem Au
DO  - 10.1021/acsbiomedchemau.6c00121
UR  - https://europepmc.org/article/MED/42921024
AB  - Proximity is a fundamental prerequisite for a diverse range of biological processes. Chemically induced proximity strategies exploit this principle to achieve the controllable modulation of targets of interest through programmable biomolecular interactions. By rewiring biological interactions, induced-proximity technologies can regulate protein stability, activity, localization, transcription, and signaling. Recent advances have greatly expanded the repertoire of recruitable effector proteins, enabling the manipulation of challenging targets previously considered intractable. In this review, we summarize the conceptual evolution and mechanistic diversity of induced-proximity technologies, highlighting platforms for targeted protein degradation, stabilization, post-translational modification editing, protein relocalization, and transcriptional control.
SN  - 2694-2437
ER  -