Pretreatment with polyphenols from
- 1School of Chinese Materia Medica
- 2School of Pharmacy
- 3School of Chinese Materia Medica; Corresponding authors.
Abstract
Thymus quinquecostatus Celak., a member of the genus Thymus , is an edible medicinal plant rich in polyphenolic compounds (TCPRF). Although accumulating evidence suggests the beneficial effects of Thymus species, the underlying mechanisms of TCPRF in cardiovascular protection remain to be fully elucidated. Endoplasmic reticulum stress (ERS) has been implicated in the pathogenesis of myocardial ischemia/reperfusion injury (MIRI) and is considered a promising therapeutic target. In this study, network pharmacology prediction, GEO dataset validation, and molecular docking analysis were integrated to systematically investigate the potential molecular mechanisms of TCPRF against MIRI via ERS regulation, with HSPA5 identified as a key target. Furthermore, we aimed to experimentally validate the effects of TCPRF on ERS-mediated cardiomyocyte apoptosis in a rat model of MIRI. The results demonstrated that TCPRF treatment significantly ameliorated myocardial pathological alterations, reduced myocardial infarct size, and decreased serum levels of CK and LDH in MIRI rats. Moreover, TCPRF administration downregulated the expression of GRP78, ATF6, and CHOP, increased the Bcl-2/Bax ratio, and suppressed cardiomyocyte apoptosis in myocardial tissues. Treatment with TCPRF ameliorates endoplasmic reticulum stress-mediated cardiomyocyte apoptosis induced by myocardial ischemia-reperfusion injury, which provides an experimental basis for subsequent studies into the regulatory targets of TCPRF in the protection against myocardial ischemia-reperfusion injury.
Related
- Recent Advances in Sensing Strategies for the Detection and Discrimination of Tea Polyphenols.
- Impact of Simulated Gastrointestinal Digestion on Antiglycoxidant Activity of Lemon Verbena (Aloysia triphylla) Herbal Tea and Characterization of Key Polyphenols via DPPH/MGO Pre-Column HPLC
- Dietary Polyphenols and Cardiovascular Health: From Bioavailability to Clinical Relevance
- Integrated Chemical Profiling and Toxicological Assessment of Total Polyphenols from Cydonia oblonga Mill. Reveals Potential Safety Concerns Under High-Dose Exposure.
- Impact of Sonication on the Yield and Properties of Starch and Polyphenols from Cassava (Manihot esculenta Crantz) Rhizome
BibTeX
@article{xie2026pretreatment,
title = {{Pretreatment with polyphenols from}},
author = {Lan Xie and Yue Liu and Fenxi Niu and Shusheng Fan and Hanwen Xing and Yanping Yin and Hua Yang and Meng Shen and Hong Sui and Fang Fang and Gaimei She},
journal = {Journal of Functional Foods},
year = {2026},
month = oct,
doi = {10.1016/j.jff.2026.107547},
url = {https://doi.org/10.1016/j.jff.2026.107547},
note = {CC BY},
}
RIS
TY - JOUR
TI - Pretreatment with polyphenols from
AU - Lan Xie
AU - Yue Liu
AU - Fenxi Niu
AU - Shusheng Fan
AU - Hanwen Xing
AU - Yanping Yin
AU - Hua Yang
AU - Meng Shen
AU - Hong Sui
AU - Fang Fang
AU - Gaimei She
PY - 2026
DA - 2026/10/30
JO - Journal of Functional Foods
DO - 10.1016/j.jff.2026.107547
UR - https://doi.org/10.1016/j.jff.2026.107547
AB - Thymus quinquecostatus Celak., a member of the genus Thymus , is an edible medicinal plant rich in polyphenolic compounds (TCPRF). Although accumulating evidence suggests the beneficial effects of Thymus species, the underlying mechanisms of TCPRF in cardiovascular protection remain to be fully elucidated. Endoplasmic reticulum stress (ERS) has been implicated in the pathogenesis of myocardial ischemia/reperfusion injury (MIRI) and is considered a promising therapeutic target. In this study, network pharmacology prediction, GEO dataset validation, and molecular docking analysis were integrated to systematically investigate the potential molecular mechanisms of TCPRF against MIRI via ERS regulation, with HSPA5 identified as a key target. Furthermore, we aimed to experimentally validate the effects of TCPRF on ERS-mediated cardiomyocyte apoptosis in a rat model of MIRI. The results demonstrated that TCPRF treatment significantly ameliorated myocardial pathological alterations, reduced myocardial infarct size, and decreased serum levels of CK and LDH in MIRI rats. Moreover, TCPRF administration downregulated the expression of GRP78, ATF6, and CHOP, increased the Bcl-2/Bax ratio, and suppressed cardiomyocyte apoptosis in myocardial tissues. Treatment with TCPRF ameliorates endoplasmic reticulum stress-mediated cardiomyocyte apoptosis induced by myocardial ischemia-reperfusion injury, which provides an experimental basis for subsequent studies into the regulatory targets of TCPRF in the protection against myocardial ischemia-reperfusion injury.
SN - 1756-4646
SN - 2214-9414
ER -