Prevalence of common mental health disorders and associated factors among adolescents and young people living with HIV in Lusaka, Zambia
11 affiliations
- 1Zambart, Lusaka, Zambia
- 2CIDRZ, Analysis Unit, Lusaka, Zambia
- 3Ministry of Health, Clinical Care, Lusaka, Zambia
- 4University of Lusaka, Lusaka, Zambia
- 5Serenity Harm Reduction Programme Zambia, Lusaka, Zambia
- 6Ministry of Health, Lusaka, Zambia
- 7Lifeline Childline Zambia, Lusaka, Zambia
- 8Ministry of Health, Clinical Care and NCD Unit, Lusaka, Zambia
- 9Seed Global Health, Programs, Lusaka, Zambia
- 10Department of Epidemiology and Biostatistics, School of Public Health, University of Zambia, Lusaka, Zambia
- 11School of Medicine, University of Zambia, Lusaka, Zambia
Abstract
Mental health disorders (MHDs) are prevalent among adolescents and young people living with HIV (AYPLHIV) and can adversely affect wellbeing, antiretroviral therapy adherence and engagement in care. We aimed to determine the prevalence of common MHDs and associated factors among AYPLHIV receiving routine HIV care in Lusaka, Zambia. We conducted a cross-sectional survey embedded within the AdoMinds mixed-methods implementation study. The study was conducted from September 2023 to May 2024 at Chipata Level 1 Hospital, Lusaka. All AYP aged 15–24 years enrolled in ART care during the study period were invited to participate. A trained research assistant administered a tablet-based questionnaire including validated screening tools for depression, anxiety, post-traumatic stress disorder and substance use. Logistic regression was used to determine factors associated with MHDs. We enrolled 416 AYPLHIV (71.4% of 583 registered in care); 268 (64.4%) were female and the median age was 20 years (IQR: 18, 23). Overall 71.4% (297/416) screened positive for at least one MHD. Depression was most prevalent at 67.1% (279/416), followed by anxiety at 35.3% (147/416). Having at least one MHD was associated with feeling stigmatised because of HIV (AOR = 1.99, 95% CI: 1.10-3.63, p = 0.024). There was borderline evidence that a history of smoking was associated with higher odds of having at least one MHD (AOR = 4.24, 95% CI: 0.98-18.30, p = 0.053). Compared with participants with both parents alive, having lost one parent (AOR = 0.46, 95% CI: 0.21-0.97, p = 0.042) or both parents (AOR = 0.38, 95% CI: 0.18-0.80, p = 0.010) was associated with lower odds of having an MHD. Common MHDs were highly prevalent among AYPLHIV receiving routine HIV care, with HIV-related stigma associated with higher odds of MHDs. Integrating mental health screening and referral pathways into adolescent HIV services may support earlier identification and care.
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BibTeX
@article{shanaube2026prevalence,
title = {{Prevalence of common mental health disorders and associated factors among adolescents and young people living with HIV in Lusaka, Zambia}},
author = {Kwame Shanaube and Suwilanji Simwanza and Buumba Tapisha and Dennis Ngosa and Lucheka Sigande and Isaac Mshanga and Choongo Mulungu and O’jay Mwenya and Jane Grace Mwamba and Lihlizulu Thabo Moyo and Charles Moyo and Temwani Mbambara and Gabriel Lungu and Madalitso Mbewe and Given Moonga and Brian Maila},
journal = {PLOS Mental Health},
year = {2026},
month = oct,
doi = {10.1371/journal.pmen.0000710},
url = {https://journals.plos.org/mentalhealth/article?id=10.1371/journal.pmen.0000710},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Prevalence of common mental health disorders and associated factors among adolescents and young people living with HIV in Lusaka, Zambia
AU - Kwame Shanaube
AU - Suwilanji Simwanza
AU - Buumba Tapisha
AU - Dennis Ngosa
AU - Lucheka Sigande
AU - Isaac Mshanga
AU - Choongo Mulungu
AU - O’jay Mwenya
AU - Jane Grace Mwamba
AU - Lihlizulu Thabo Moyo
AU - Charles Moyo
AU - Temwani Mbambara
AU - Gabriel Lungu
AU - Madalitso Mbewe
AU - Given Moonga
AU - Brian Maila
PY - 2026
DA - 2026/10/12
JO - PLOS Mental Health
DO - 10.1371/journal.pmen.0000710
UR - https://journals.plos.org/mentalhealth/article?id=10.1371/journal.pmen.0000710
AB - Mental health disorders (MHDs) are prevalent among adolescents and young people living with HIV (AYPLHIV) and can adversely affect wellbeing, antiretroviral therapy adherence and engagement in care. We aimed to determine the prevalence of common MHDs and associated factors among AYPLHIV receiving routine HIV care in Lusaka, Zambia. We conducted a cross-sectional survey embedded within the AdoMinds mixed-methods implementation study. The study was conducted from September 2023 to May 2024 at Chipata Level 1 Hospital, Lusaka. All AYP aged 15–24 years enrolled in ART care during the study period were invited to participate. A trained research assistant administered a tablet-based questionnaire including validated screening tools for depression, anxiety, post-traumatic stress disorder and substance use. Logistic regression was used to determine factors associated with MHDs. We enrolled 416 AYPLHIV (71.4% of 583 registered in care); 268 (64.4%) were female and the median age was 20 years (IQR: 18, 23). Overall 71.4% (297/416) screened positive for at least one MHD. Depression was most prevalent at 67.1% (279/416), followed by anxiety at 35.3% (147/416). Having at least one MHD was associated with feeling stigmatised because of HIV (AOR = 1.99, 95% CI: 1.10-3.63, p = 0.024). There was borderline evidence that a history of smoking was associated with higher odds of having at least one MHD (AOR = 4.24, 95% CI: 0.98-18.30, p = 0.053). Compared with participants with both parents alive, having lost one parent (AOR = 0.46, 95% CI: 0.21-0.97, p = 0.042) or both parents (AOR = 0.38, 95% CI: 0.18-0.80, p = 0.010) was associated with lower odds of having an MHD. Common MHDs were highly prevalent among AYPLHIV receiving routine HIV care, with HIV-related stigma associated with higher odds of MHDs. Integrating mental health screening and referral pathways into adolescent HIV services may support earlier identification and care.
SN - 2837-8156
ER -