Initial treatment patterns and survival in biliary tract cancer: A retrospective cohort study in Kyoto, Japan
Abstract
Purpose: We aimed to describe the treatment landscape for biliary tract cancer (BTC), including patient characteristics, initial treatment patterns, and survival outcomes, and examine factors associated with receiving no active anticancer treatment (NT). Methods: We conducted a retrospective cohort study of patients diagnosed with BTC between April 2014 and March 2020 identified through cancer registries and linked with the Kyoto City Integrated Database. Patient characteristics, factors associated with NT, and median overall survival (mOS) were analyzed using multivariate logistic regression and Kaplan-Meier methods. Results: Among 1367 eligible patients, 30.1% underwent curative surgery, whereas 44.3% received NT. NT was significantly associated with distant metastasis (adjusted odds ratio [AOR] 4.24; 95% CI 2.92-6.15), certified long-term care (AOR 2.34; 1.76-3.10), and age ≥75 years (AOR 2.23; 1.70-2.93). The mOS was 54.6 months in the curative surgery group, 7.7-18.0 months in the noncurative surgical and nonsurgical treatment groups, and 5.2 months in the NT group. Conclusions: Over 40% of patients with BTC in Kyoto City received no active treatment and had shorter survival. Older age and certification for long-term care were significantly associated with the selection of no active treatment. These findings describe treatment patterns among older adults with BTC and may help inform future strategies to improve treatment access, supportive care, and early detection.
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BibTeX
@article{tateyama2026initial,
title = {{Initial treatment patterns and survival in biliary tract cancer: A retrospective cohort study in Kyoto, Japan}},
author = {Yukiko Tateyama and Sachiyo Shirakawa and Makoto Namba and Takashi Noda and Tomonari Shimamoto and Koichi Fujita and Yuki Nakamura and Yoko Hamada and Hiroshi Kitagawa and Norihiro Nishioka and Yoshimitsu Takahashi and Takeo Nakayama and Taku Iwami},
journal = {Cancer Treatment and Research Communications},
year = {2026},
month = jul,
doi = {10.1016/j.ctarc.2026.101339},
url = {https://hal.science/hal-05739184v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Initial treatment patterns and survival in biliary tract cancer: A retrospective cohort study in Kyoto, Japan
AU - Yukiko Tateyama
AU - Sachiyo Shirakawa
AU - Makoto Namba
AU - Takashi Noda
AU - Tomonari Shimamoto
AU - Koichi Fujita
AU - Yuki Nakamura
AU - Yoko Hamada
AU - Hiroshi Kitagawa
AU - Norihiro Nishioka
AU - Yoshimitsu Takahashi
AU - Takeo Nakayama
AU - Taku Iwami
PY - 2026
DA - 2026/07/29
JO - Cancer Treatment and Research Communications
DO - 10.1016/j.ctarc.2026.101339
UR - https://hal.science/hal-05739184v1
AB - Purpose: We aimed to describe the treatment landscape for biliary tract cancer (BTC), including patient characteristics, initial treatment patterns, and survival outcomes, and examine factors associated with receiving no active anticancer treatment (NT). Methods: We conducted a retrospective cohort study of patients diagnosed with BTC between April 2014 and March 2020 identified through cancer registries and linked with the Kyoto City Integrated Database. Patient characteristics, factors associated with NT, and median overall survival (mOS) were analyzed using multivariate logistic regression and Kaplan-Meier methods. Results: Among 1367 eligible patients, 30.1% underwent curative surgery, whereas 44.3% received NT. NT was significantly associated with distant metastasis (adjusted odds ratio [AOR] 4.24; 95% CI 2.92-6.15), certified long-term care (AOR 2.34; 1.76-3.10), and age ≥75 years (AOR 2.23; 1.70-2.93). The mOS was 54.6 months in the curative surgery group, 7.7-18.0 months in the noncurative surgical and nonsurgical treatment groups, and 5.2 months in the NT group. Conclusions: Over 40% of patients with BTC in Kyoto City received no active treatment and had shorter survival. Older age and certification for long-term care were significantly associated with the selection of no active treatment. These findings describe treatment patterns among older adults with BTC and may help inform future strategies to improve treatment access, supportive care, and early detection.
SN - 2468-2942
ER -