Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model
- 1Uniformed Services University of the Health Sciences
Abstract
Traumatic brain injury (TBI) is the leading cause of death and disability in people under 40 worldwide. There is an unmet need for detection and treatment of life-threatening TBI when computed tomography (CT) scanners and neurosurgeons are unavailable. We developed a new handheld frequency-domain multidetector infrared hemorrhage detection device. Using the new device, military pre-hospital medics required <4 minutes to detect life-threatening subdural hematoma in a sheep model. We developed a second device that allows non-neurosurgeons to safely create a burr hole and partially remove clotted subdural blood. In sheep, the treatment device reduced intracranial pressure within 20 minutes, and improved post-anesthesia blinded neurological outcomes. With human use adaptation, these devices could allow rapid detection and initial treatment of some life-threatening TBIs in challenging situations.
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BibTeX
@misc{brody2026rapid,
title = {{Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model}},
author = {D. L. Brody and B. A. Dengler and J. P. Angelo and D. W. Blodgett and A. B. Cohen and D. G. Drewry and M. J. Fitch and N. Goonasekeram and A. J. Januszkiewicz and T. Knapp and B. Kohler and J. Mark and I. S. McAdams and K. M. Perrino and C. L. Rodriguez and T. A. Sleasman and G. L. Spicer and N. E. Steiner and A. P. Vieth and J. J. Wathen and K. C. Wolfe},
howpublished = {bioRxiv},
year = {2026},
month = nov,
doi = {10.64898/2026.11.03.763711},
url = {https://www.biorxiv.org/content/10.64898/2026.11.03.763711v1},
note = {CC0},
}
RIS
TY - UNPB
TI - Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model
AU - D. L. Brody
AU - B. A. Dengler
AU - J. P. Angelo
AU - D. W. Blodgett
AU - A. B. Cohen
AU - D. G. Drewry
AU - M. J. Fitch
AU - N. Goonasekeram
AU - A. J. Januszkiewicz
AU - T. Knapp
AU - B. Kohler
AU - J. Mark
AU - I. S. McAdams
AU - K. M. Perrino
AU - C. L. Rodriguez
AU - T. A. Sleasman
AU - G. L. Spicer
AU - N. E. Steiner
AU - A. P. Vieth
AU - J. J. Wathen
AU - K. C. Wolfe
PY - 2026
DA - 2026/11/03
PB - bioRxiv
DO - 10.64898/2026.11.03.763711
UR - https://www.biorxiv.org/content/10.64898/2026.11.03.763711v1
AB - Traumatic brain injury (TBI) is the leading cause of death and disability in people under 40 worldwide. There is an unmet need for detection and treatment of life-threatening TBI when computed tomography (CT) scanners and neurosurgeons are unavailable. We developed a new handheld frequency-domain multidetector infrared hemorrhage detection device. Using the new device, military pre-hospital medics required <4 minutes to detect life-threatening subdural hematoma in a sheep model. We developed a second device that allows non-neurosurgeons to safely create a burr hole and partially remove clotted subdural blood. In sheep, the treatment device reduced intracranial pressure within 20 minutes, and improved post-anesthesia blinded neurological outcomes. With human use adaptation, these devices could allow rapid detection and initial treatment of some life-threatening TBIs in challenging situations.
ER -