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Peer-reviewedCC BY 4.0Nutrients

Efficacy and Safety of Lythrum salicaria Extract on Body Fat Reduction in Adults with a BMI of 23–30 kg/m2: A Randomized, Double-Blind, Placebo-Controlled Trial

  • Bong-Jin Shin1,2
  • Hye-Jin Park3
  • Yea-Jin Park4,5
  • Hyo-Jin An5,6
  • Su Shin7
  • Yun-Yeop Cha4
  • In Heo2,8
8 affiliations
  1. 1Department of Korean Medicine, The Graduate School, Pusan National University, Yangsan 50612, Republic of Korea
  2. 2Department of Korean Medicine Rehabilitation, Pusan National University Korean Medicine Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Republic of Korea
  3. 3Department of Rehabilitation Medicine of Korean Medicine, Se-Myung University Chungju Korean Medicine Hospital, 63 Sangbang 4-gil, Chungju 27429, Republic of Korea
  4. 4Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Sangji University, 80 Sangjidae-gil, Wonju 26338, Republic of Korea
  5. 5College of Pharmacy and Institute of Integrated Pharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
  6. 6Department of Precision Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea
  7. 7Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea
  8. 8The School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea
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Abstract

Background/Objectives: Plant-derived ingredients have attracted interest as adjuncts for reducing body fat, but clinical evidence for Lythrum salicaria extract alone remains limited. We evaluated its effects on body fat and its safety in adults with a body mass index (BMI) of 23–30 kg/m2. Methods: Ninety adults aged 19–75 years participated in a single-center, randomized, double-blind, placebo-controlled trial. Participants received either 500 mg/day of L. salicaria extract powder (corresponding to approximately 400 mg/day of plant-derived extract solids) or placebo for 12 weeks. The primary endpoint was the change in body fat mass from baseline to day 84, assessed by dual-energy X-ray absorptiometry (DXA). Efficacy was evaluated primarily in the per-protocol (PP) population, with supporting intention-to-treat (ITT) analyses. Anthropometric measures, other DXA outcomes, and blood markers were assessed as secondary endpoints. Results: The PP population included 84 participants. Baseline-adjusted differences in body fat mass change, expressed as extract minus placebo, were −2.01 kg (95% confidence interval [CI], −2.51 to −1.52; p < 0.001) in the PP population and −2.04 kg (95% CI, −2.66 to −1.42; p < 0.001) in the ITT population. Exploratory secondary analyses favored the extract for BMI, body weight, body fat percentage, and adiponectin. No serious adverse events occurred. Conclusions: Supplementation with L. salicaria extract powder for 12 weeks was associated with a reduction in DXA-measured body fat mass compared with placebo. Larger trials with longer follow-up are needed to confirm the findings and investigate the mechanisms involved.

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Cite

BibTeXRIS
BibTeX
@article{shin2026efficacy,
  title = {{Efficacy and Safety of Lythrum salicaria Extract on Body Fat Reduction in Adults with a BMI of 23–30 kg/m2: A Randomized, Double-Blind, Placebo-Controlled Trial}},
  author = {Bong-Jin Shin and Hye-Jin Park and Yea-Jin Park and Hyo-Jin An and Su Shin and Yun-Yeop Cha and In Heo},
  journal = {Nutrients},
  year = {2026},
  month = oct,
  doi = {10.3390/nu18203342},
  url = {https://www.mdpi.com/2072-6643/18/20/3342},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Efficacy and Safety of Lythrum salicaria Extract on Body Fat Reduction in Adults with a BMI of 23–30 kg/m2: A Randomized, Double-Blind, Placebo-Controlled Trial
AU  - Bong-Jin Shin
AU  - Hye-Jin Park
AU  - Yea-Jin Park
AU  - Hyo-Jin An
AU  - Su Shin
AU  - Yun-Yeop Cha
AU  - In Heo
PY  - 2026
DA  - 2026/10/01
JO  - Nutrients
DO  - 10.3390/nu18203342
UR  - https://www.mdpi.com/2072-6643/18/20/3342
AB  - Background/Objectives: Plant-derived ingredients have attracted interest as adjuncts for reducing body fat, but clinical evidence for Lythrum salicaria extract alone remains limited. We evaluated its effects on body fat and its safety in adults with a body mass index (BMI) of 23–30 kg/m2. Methods: Ninety adults aged 19–75 years participated in a single-center, randomized, double-blind, placebo-controlled trial. Participants received either 500 mg/day of L. salicaria extract powder (corresponding to approximately 400 mg/day of plant-derived extract solids) or placebo for 12 weeks. The primary endpoint was the change in body fat mass from baseline to day 84, assessed by dual-energy X-ray absorptiometry (DXA). Efficacy was evaluated primarily in the per-protocol (PP) population, with supporting intention-to-treat (ITT) analyses. Anthropometric measures, other DXA outcomes, and blood markers were assessed as secondary endpoints. Results: The PP population included 84 participants. Baseline-adjusted differences in body fat mass change, expressed as extract minus placebo, were −2.01 kg (95% confidence interval [CI], −2.51 to −1.52; p < 0.001) in the PP population and −2.04 kg (95% CI, −2.66 to −1.42; p < 0.001) in the ITT population. Exploratory secondary analyses favored the extract for BMI, body weight, body fat percentage, and adiponectin. No serious adverse events occurred. Conclusions: Supplementation with L. salicaria extract powder for 12 weeks was associated with a reduction in DXA-measured body fat mass compared with placebo. Larger trials with longer follow-up are needed to confirm the findings and investigate the mechanisms involved.
SN  - 2072-6643
ER  -