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Peer-reviewedCC BYJournal of Molecular and Cellular Cardiology Plus

Temporal changes in monocyte subsets and cytokine production capacity of mononuclear cells following myocardial infarction

  • Jonathan Los1
  • Ilse H. Hol2
  • Frans B. Mensink1
  • Malin Östman2
  • Aysun Cetinyurek-Yavuz3
  • Jan H. Cornel4
  • Robert-Jan M. van Geuns1
  • Niels P. Riksen2
  • Saloua El Messaoudi5
5 affiliations
  1. 1Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands
  2. 2Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands
  3. 3Department of IQ Health, Radboud University Medical Centre, Nijmegen, the Netherlands
  4. 4Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Cardiology, Northwest Clinics, Alkmaar, the Netherlands; Dutch Network for Cardiovascular Research (WCN), Utrecht, the Netherlands
  5. 5Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands; Corresponding author at: Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.
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Abstract

Following myocardial infarction (MI), recruited monocytes play an essential role in tissue repair and scar formation. However, the temporal changes in circulating monocyte subsets and their functional characteristics remain incompletely understood. We investigated systemic inflammation and circulating monocyte heterogeneity in 72 patients during the first 12 weeks after MI. Systemic inflammation was markedly increased immediately after MI, as reflected by significant elevated C-reactive protein and interleukin-6 (IL-6) levels. During follow-up, the proportion of classical monocytes decreased, whereas the relative abundance of non-classical monocytes increased. In the acute phase, cluster of differentiation 11b expression on intermediate monocytes was elevated, while peripheral blood mononuclear cells produced lower levels of the anti-inflammatory cytokines IL-10 and IL-1Ra. Together, the results support the presence of a relatively more inflammatory monocyte profile during the acute phase of MI.

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Cite

BibTeXRIS
BibTeX
@article{los2026temporal,
  title = {{Temporal changes in monocyte subsets and cytokine production capacity of mononuclear cells following myocardial infarction}},
  author = {Jonathan Los and Ilse H. Hol and Frans B. Mensink and Malin Östman and Aysun Cetinyurek-Yavuz and Jan H. Cornel and Robert-Jan M. van Geuns and Niels P. Riksen and Saloua El Messaoudi},
  journal = {Journal of Molecular and Cellular Cardiology Plus},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jmccpl.2026.100876},
  url = {https://doi.org/10.1016/j.jmccpl.2026.100876},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Temporal changes in monocyte subsets and cytokine production capacity of mononuclear cells following myocardial infarction
AU  - Jonathan Los
AU  - Ilse H. Hol
AU  - Frans B. Mensink
AU  - Malin Östman
AU  - Aysun Cetinyurek-Yavuz
AU  - Jan H. Cornel
AU  - Robert-Jan M. van Geuns
AU  - Niels P. Riksen
AU  - Saloua El Messaoudi
PY  - 2026
DA  - 2026/10/09
JO  - Journal of Molecular and Cellular Cardiology Plus
DO  - 10.1016/j.jmccpl.2026.100876
UR  - https://doi.org/10.1016/j.jmccpl.2026.100876
AB  - Following myocardial infarction (MI), recruited monocytes play an essential role in tissue repair and scar formation. However, the temporal changes in circulating monocyte subsets and their functional characteristics remain incompletely understood. We investigated systemic inflammation and circulating monocyte heterogeneity in 72 patients during the first 12 weeks after MI. Systemic inflammation was markedly increased immediately after MI, as reflected by significant elevated C-reactive protein and interleukin-6 (IL-6) levels. During follow-up, the proportion of classical monocytes decreased, whereas the relative abundance of non-classical monocytes increased. In the acute phase, cluster of differentiation 11b expression on intermediate monocytes was elevated, while peripheral blood mononuclear cells produced lower levels of the anti-inflammatory cytokines IL-10 and IL-1Ra. Together, the results support the presence of a relatively more inflammatory monocyte profile during the acute phase of MI.
SN  - 2772-9761
ER  -