Skin Wound Dressings Based on Biocompatible Nanofibers Loaded with the Mastoparan-Mo Peptide to Promote Regeneration and Control Infection in Skin Wounds
4 affiliations
- 1Universidade Católica de Brasília , , , ,
- 2Universidade Federal do Rio de Janeiro , , , ,
- 3Universidade de Brasília , , , ,
- 4Universidade Católica Dom Bosco , , , ,
Abstract
Skin wounds represent a major clinical challenge, particularly in chronic nonhealing cases associated with conditions such as diabetes, vascular disorders, prolonged immobilization, or trauma. These wounds involve a prolonged inflammatory process that impairs tissue regeneration, increases the risk of opportunistic infections, and further hinders healing, reducing quality of life and even threatening patient survival. Moreover, wound treatment significantly increases healthcare costs, making wound management a growing public health concern. In this study, we fabricated a series of skin wound dressings based on biocompatible nanofiber mats loaded with the antimicrobial and pro-regenerative peptide Mastoparan-Mo. We evaluated their physicochemical properties, antibacterial activity against clinically relevant bacteria, and pro-regenerative effects. These wound dressings exhibited well-defined ultrastructural organization, appropriate physicochemical properties, high hydrophilicity, and controlled-release behavior, supporting their potential as functional biomaterials. Moreover, they displayed antibacterial activity against several bacterial species commonly associated with skin infections and showed high biocompatibility in in vitro assays, promoting cell proliferation and motility in a model of primary human dermal fibroblasts. To assess the translational potential of these biomaterials, we used a model based on ex vivo human skin cultures derived from healthy skin explants, which preserve native tissue architecture and cellular heterogeneity. Using this model, we demonstrated that nanofiber wound dressings loaded with the Mastoparan-Mo peptide promote tissue regeneration in skin injuries within a physiologically relevant platform that closely mimics human skin in vivo.
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BibTeX
@article{diazmartin2026skin,
title = {{Skin Wound Dressings Based on Biocompatible Nanofibers Loaded with the Mastoparan-Mo Peptide to Promote Regeneration and Control Infection in Skin Wounds}},
author = {Rubén D. Díaz-Martin and Angela Y. Becerra-Lovera and Guilherme Varejão S. Pasqual and Nathália Ribeiro Lobo and Stefhani Barcelos and Maria Victória Souto-Silva and Juliana Lott de Carvalho and Octávio Luiz Franco and Marcos L. Dias and Simoni Campos Dias},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c02591},
url = {https://pubs.acs.org/acsodf/article/11/41/62544/5444918/Skin-Wound-Dressings-Based-on-Biocompatible},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Skin Wound Dressings Based on Biocompatible Nanofibers Loaded with the Mastoparan-Mo Peptide to Promote Regeneration and Control Infection in Skin Wounds
AU - Rubén D. Díaz-Martin
AU - Angela Y. Becerra-Lovera
AU - Guilherme Varejão S. Pasqual
AU - Nathália Ribeiro Lobo
AU - Stefhani Barcelos
AU - Maria Victória Souto-Silva
AU - Juliana Lott de Carvalho
AU - Octávio Luiz Franco
AU - Marcos L. Dias
AU - Simoni Campos Dias
PY - 2026
DA - 2026/10/05
JO - ACS Omega
DO - 10.1021/acsomega.6c02591
UR - https://pubs.acs.org/acsodf/article/11/41/62544/5444918/Skin-Wound-Dressings-Based-on-Biocompatible
AB - Skin wounds represent a major clinical challenge, particularly in chronic nonhealing cases associated with conditions such as diabetes, vascular disorders, prolonged immobilization, or trauma. These wounds involve a prolonged inflammatory process that impairs tissue regeneration, increases the risk of opportunistic infections, and further hinders healing, reducing quality of life and even threatening patient survival. Moreover, wound treatment significantly increases healthcare costs, making wound management a growing public health concern. In this study, we fabricated a series of skin wound dressings based on biocompatible nanofiber mats loaded with the antimicrobial and pro-regenerative peptide Mastoparan-Mo. We evaluated their physicochemical properties, antibacterial activity against clinically relevant bacteria, and pro-regenerative effects. These wound dressings exhibited well-defined ultrastructural organization, appropriate physicochemical properties, high hydrophilicity, and controlled-release behavior, supporting their potential as functional biomaterials. Moreover, they displayed antibacterial activity against several bacterial species commonly associated with skin infections and showed high biocompatibility in in vitro assays, promoting cell proliferation and motility in a model of primary human dermal fibroblasts. To assess the translational potential of these biomaterials, we used a model based on ex vivo human skin cultures derived from healthy skin explants, which preserve native tissue architecture and cellular heterogeneity. Using this model, we demonstrated that nanofiber wound dressings loaded with the Mastoparan-Mo peptide promote tissue regeneration in skin injuries within a physiologically relevant platform that closely mimics human skin in vivo.
SN - 2470-1343
ER -