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Peer-reviewedCC BY-NC-NDJournal of cardiothoracic surgery

miR-511 suppresses non-small cell lung cancer by targeting EREG.

  • Chumeng Zhu1,2
  • Dong Liu3
  • Minjie Jiang4
  • Haitao Huang1,2
  • Yu Chen1,2
  • Haisheng Zhang3
  • Baofu Chen5,6
  • Kai Liu7,8,9
9 affiliations
  1. 1Taizhou Central Hospital (Taizhou University Hospital), Tai Zhou, 318000, P.R. China.
  2. 2Taizhou Central Hospital of Wenzhou Medical University, Tai Zhou, 318000, P.R. China.
  3. 3Department of Radiology, The first hospital of Tsinghua University, Bejing, 100016, P.R. China.
  4. 4Infectious Diseases Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, 250000, Shandong Province, P.R. China.
  5. 5Taizhou Central Hospital (Taizhou University Hospital), Tai Zhou, 318000, P.R. China. [email protected].
  6. 6Taizhou Central Hospital of Wenzhou Medical University, Tai Zhou, 318000, P.R. China. [email protected].
  7. 7Taizhou Central Hospital (Taizhou University Hospital), Tai Zhou, 318000, P.R. China. [email protected].
  8. 8Taizhou Central Hospital of Wenzhou Medical University, Tai Zhou, 318000, P.R. China. [email protected].
  9. 9Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Zhejiang International Science and Technology Cooperation Base for Biomass Resources Development and Utilization, Taizhou, 318000, Zhejiang Province, P.R. China. [email protected].
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Abstract

Background

miR-511 is a well-known tumor suppressor in many tumor types. However, whether miR-511 directly regulates EREG in non-small cell lung cancer (NSCLC) and the functional consequences of this regulation have not been investigated.Methods

Real-time quantitative polymerase chain reaction (qRT-PCR) was used to measure miR-511 expression. The proliferation, invasion and migration abilities of NSCLC cell lines A549 and H460 were determined by CCK-8, colony formation, and Transwell assays. RNA-seq was used to screen the target genes of miR-511. A xenograft mouse model was established to validate the tumor-suppressive role of miR-511 in vivo.Results

The expression of miR-511 is significantly down-regulated in NSCLC tissues and cells. The inducing of miR-511 dramatically inhibit the proliferation, invasion and migration of NSCLC cells. TargetScan predicates that EREG might be a target gene of miR-511. Dual-luciferase reporter assay confirmed that miR-511 directly binds to the 3'-UTR of EREG. Induction of MiR-511 significantly down-regulated the mRNA and protein levels of EREG, thus validating the prediction. Moreover, rescue experiments show that EREG overexpression impairs the effect of miR-511 on suppressing the malignant phenotype of NSCLC cells. Furthermore, in vivo xenograft experiments demonstrated that miR-511 overexpression significantly suppressed NSCLC tumor growth and reduced EREG expression in tumor tissues.Conclusion

miR-511 inhibits the proliferation and metastasis of NSCLC by down-regulating the expression of EREG. The miR-511-EREG axis may provide a potential basis for future therapeutic exploration in NSCLC.

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Cite

BibTeXRIS
BibTeX
@article{zhu2026mir511,
  title = {{miR-511 suppresses non-small cell lung cancer by targeting EREG.}},
  author = {Chumeng Zhu and Dong Liu and Minjie Jiang and Haitao Huang and Yu Chen and Haisheng Zhang and Baofu Chen and Kai Liu},
  journal = {Journal of cardiothoracic surgery},
  year = {2026},
  month = aug,
  doi = {10.1186/s13019-026-04508-9},
  url = {https://europepmc.org/article/MED/43010027},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - miR-511 suppresses non-small cell lung cancer by targeting EREG.
AU  - Chumeng Zhu
AU  - Dong Liu
AU  - Minjie Jiang
AU  - Haitao Huang
AU  - Yu Chen
AU  - Haisheng Zhang
AU  - Baofu Chen
AU  - Kai Liu
PY  - 2026
DA  - 2026/08/12
JO  - Journal of cardiothoracic surgery
DO  - 10.1186/s13019-026-04508-9
UR  - https://europepmc.org/article/MED/43010027
AB  - Background  miR-511 is a well-known tumor suppressor in many tumor types. However, whether miR-511 directly regulates EREG in non-small cell lung cancer (NSCLC) and the functional consequences of this regulation have not been investigated.Methods  Real-time quantitative polymerase chain reaction (qRT-PCR) was used to measure miR-511 expression. The proliferation, invasion and migration abilities of NSCLC cell lines A549 and H460 were determined by CCK-8, colony formation, and Transwell assays. RNA-seq was used to screen the target genes of miR-511. A xenograft mouse model was established to validate the tumor-suppressive role of miR-511 in vivo.Results  The expression of miR-511 is significantly down-regulated in NSCLC tissues and cells. The inducing of miR-511 dramatically inhibit the proliferation, invasion and migration of NSCLC cells. TargetScan predicates that EREG might be a target gene of miR-511. Dual-luciferase reporter assay confirmed that miR-511 directly binds to the 3'-UTR of EREG. Induction of MiR-511 significantly down-regulated the mRNA and protein levels of EREG, thus validating the prediction. Moreover, rescue experiments show that EREG overexpression impairs the effect of miR-511 on suppressing the malignant phenotype of NSCLC cells. Furthermore, in vivo xenograft experiments demonstrated that miR-511 overexpression significantly suppressed NSCLC tumor growth and reduced EREG expression in tumor tissues.Conclusion  miR-511 inhibits the proliferation and metastasis of NSCLC by down-regulating the expression of EREG. The miR-511-EREG axis may provide a potential basis for future therapeutic exploration in NSCLC.
SN  - 1749-8090
ER  -