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Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Experience and Operation of Establishing the Korea Biobank Network for Inflammatory Bowel Disease and Colorectal Cancer

  • Yu-Jin Ko1
  • Mihyang Jeon1
  • Ji-Hyeon Lee1
  • Daeun Kwak1
  • Eun Ju Kim1
  • Hye-Ra Jung2,3
  • Ji-Hyun Seo4,5
  • Eun-Young Kim6,7
  • Eun Soo Kim8
  • Ben Kang9
  • Soo Yeun Park10
  • Man-Hoon Han11
1 more authors
  • An Na Seo11
11 affiliations
  1. 1Human Biobank, Kyungpook National University Hospital, Daegu 41940, Republic of Korea
  2. 2Department of Pathology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea
  3. 3Human Resources Bank of Keimyung University Dongsan Hospital, Daegu 42601, Republic of Korea
  4. 4Department of Pediatrics, Gyeongsang National University, Jinju 52727, Republic of Korea
  5. 5Korea Biobank Network, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea
  6. 6Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan 47392, Republic of Korea
  7. 7Inje Biobank, Inje University Busan Paik Hospital, Busan 47392, Republic of Korea
  8. 8Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea
  9. 9Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea
  10. 10Department of Surgery, Colorectal Cancer Center, School of Medicine, Kyungpook National University, Daegu 41404, Republic of Korea
  11. 11Department of Pathology, School of Medicine, Kyungpook National University, Daegu 41405, Republic of Korea
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Abstract

Background: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic condition driven by complex interactions among genetic, microbial, immunological, and environmental factors that substantially affect patients’ lives and increase the risk of colorectal cancer (CRC). Biobanks support IBD research by providing access to human biospecimens and associated data. This study aimed to describe the workflow and infrastructure of the Kyungpook National University Hospital (KNUH) Biobank, summarize the clinical characteristics of participants and the collection and distribution of biospecimens, and outline future development priorities. Methods: This descriptive report summarizes the collection and distribution activities of the KNUH Biobank from 1 July 2021 to 31 December 2025, including biospecimens collected at Kyungpook National University Chilgok Hospital and incorporated into its collection. Biospecimens and associated clinical and epidemiological data were collected from consenting participants, processed, and stored according to standard operating procedures. Bioresource distribution required formal application and committee approval. Results: The disease-focused collection comprised 1307 participants: 471 with CD (36.0%), 376 with UC (28.8%), 35 with other non-infective gastroenteritis and colitis (2.7%), and 425 with CRC (32.5%). Of these, the mean age at diagnosis was 37.7 years (SD, 23.1), and 849 participants (65.0%) were male. A total of 9577 biospecimen vials were collected from these 1307 participants, excluding the bottom-up collection. Additionally, excluding the bottom-up collection, 2400 vials were distributed through 34 approved applications during the reporting period. Conclusions: This report describes the operational framework and collection and distribution activities of the KNUH Biobank. Future priorities include improving clinical data completeness, establishing systematic longitudinal follow-up, and evaluating resource utilization and operational sustainability.

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Cite

BibTeXRIS
BibTeX
@article{ko2026experience,
  title = {{Experience and Operation of Establishing the Korea Biobank Network for Inflammatory Bowel Disease and Colorectal Cancer}},
  author = {Yu-Jin Ko and Mihyang Jeon and Ji-Hyeon Lee and Daeun Kwak and Eun Ju Kim and Hye-Ra Jung and Ji-Hyun Seo and Eun-Young Kim and Eun Soo Kim and Ben Kang and Soo Yeun Park and Man-Hoon Han and An Na Seo},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15218485},
  url = {https://www.mdpi.com/2077-0383/15/21/8485},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Experience and Operation of Establishing the Korea Biobank Network for Inflammatory Bowel Disease and Colorectal Cancer
AU  - Yu-Jin Ko
AU  - Mihyang Jeon
AU  - Ji-Hyeon Lee
AU  - Daeun Kwak
AU  - Eun Ju Kim
AU  - Hye-Ra Jung
AU  - Ji-Hyun Seo
AU  - Eun-Young Kim
AU  - Eun Soo Kim
AU  - Ben Kang
AU  - Soo Yeun Park
AU  - Man-Hoon Han
AU  - An Na Seo
PY  - 2026
DA  - 2026/10/31
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15218485
UR  - https://www.mdpi.com/2077-0383/15/21/8485
AB  - Background: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic condition driven by complex interactions among genetic, microbial, immunological, and environmental factors that substantially affect patients’ lives and increase the risk of colorectal cancer (CRC). Biobanks support IBD research by providing access to human biospecimens and associated data. This study aimed to describe the workflow and infrastructure of the Kyungpook National University Hospital (KNUH) Biobank, summarize the clinical characteristics of participants and the collection and distribution of biospecimens, and outline future development priorities. Methods: This descriptive report summarizes the collection and distribution activities of the KNUH Biobank from 1 July 2021 to 31 December 2025, including biospecimens collected at Kyungpook National University Chilgok Hospital and incorporated into its collection. Biospecimens and associated clinical and epidemiological data were collected from consenting participants, processed, and stored according to standard operating procedures. Bioresource distribution required formal application and committee approval. Results: The disease-focused collection comprised 1307 participants: 471 with CD (36.0%), 376 with UC (28.8%), 35 with other non-infective gastroenteritis and colitis (2.7%), and 425 with CRC (32.5%). Of these, the mean age at diagnosis was 37.7 years (SD, 23.1), and 849 participants (65.0%) were male. A total of 9577 biospecimen vials were collected from these 1307 participants, excluding the bottom-up collection. Additionally, excluding the bottom-up collection, 2400 vials were distributed through 34 approved applications during the reporting period. Conclusions: This report describes the operational framework and collection and distribution activities of the KNUH Biobank. Future priorities include improving clinical data completeness, establishing systematic longitudinal follow-up, and evaluating resource utilization and operational sustainability.
SN  - 2077-0383
ER  -