Light Guiding in Scattering Media Using Focused Laser-Induced Acoustic Waves with an Open Elliptical Reflector

Abstract

Light scattering in biological tissue limits deep optical imaging. Acoustic waves can modulate optical properties and enhance photon delivery, but source-positioning requirements can complicate integration with other imaging modalities. Here, we present an open elliptical reflector that focuses laser-induced acoustic waves at a spatially separated target while maintaining open optical access. We characterized the spatiotemporal optical modulation induced by the localized acoustic focus. The system increased the local transmitted-light intensity by a factor of 2.57-fold through a 2-mm-thick 1% intralipid hydrogel and enhanced fluorescence signal under two-photon excitation through a 1.5-mm-thick scattering sample. These results demonstrate spatially separated, reflector-based acoustically assisted light guiding for enhanced light delivery and fluorescence excitation through scattering media.

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BibTeX RIS

BibTeX

@misc{liu2026light,
  title = {{Light Guiding in Scattering Media Using Focused Laser-Induced Acoustic Waves with an Open Elliptical Reflector}},
  author = {Y. Liu and K. Shimada and K. Kitamura and S. Barrera and M. Ye and A. Ishijima and K. Nakagawa},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.17.752288},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.17.752288v1},
  note = {CC BY-NC-ND},
}

RIS

TY  - UNPB
TI  - Light Guiding in Scattering Media Using Focused Laser-Induced Acoustic Waves with an Open Elliptical Reflector
AU  - Y. Liu
AU  - K. Shimada
AU  - K. Kitamura
AU  - S. Barrera
AU  - M. Ye
AU  - A. Ishijima
AU  - K. Nakagawa
PY  - 2026
DA  - 2026/09/17
PB  - bioRxiv
DO  - 10.64898/2026.09.17.752288
UR  - https://www.biorxiv.org/content/10.64898/2026.09.17.752288v1
AB  - Light scattering in biological tissue limits deep optical imaging. Acoustic waves can modulate optical properties and enhance photon delivery, but source-positioning requirements can complicate integration with other imaging modalities. Here, we present an open elliptical reflector that focuses laser-induced acoustic waves at a spatially separated target while maintaining open optical access. We characterized the spatiotemporal optical modulation induced by the localized acoustic focus. The system increased the local transmitted-light intensity by a factor of 2.57-fold through a 2-mm-thick 1% intralipid hydrogel and enhanced fluorescence signal under two-photon excitation through a 1.5-mm-thick scattering sample. These results demonstrate spatially separated, reflector-based acoustically assisted light guiding for enhanced light delivery and fluorescence excitation through scattering media.
ER  -

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