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Peer-reviewedCC BY-NC-NDACS omega

Eco-friendly One-Pot Synthesis of Oxamide.

  • Maria Cristina Mascolo1,2,3
  • Laura Grauso4
  • Nicola Di Costanzo5
  • Pasquale Gallo6
  • Virginia Lanzotti4
6 affiliations
  1. 1Department of Letter and Philosophy, University of Cassino and Southern Lazio, Loc. Folcara, 03043 Cassino, FR, Italy.
  2. 2Laboratory of Materials, Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Gaetano di Biasio 43, 03043 Cassino, FR, Italy.
  3. 3Institute of Environmental Geology and Geoengineering, National Research Council, Area della Ricerca di Roma 1, Via Salaria Km 29.300, C.P. 10, Monterotondo Stazione, 00015 Montelibretti, Rome, Italy.
  4. 4Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Naples, Italy.
  5. 5Department of Engineering, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
  6. 6Department of Chemistry, Istituto Zooprofilattico Sperimentale del Mezzogiorno, via Salute 2, 80055 Portici, NA, Italy.
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Abstract

A novel, eco-friendly one-pot synthesis of oxamide was developed using nontoxic starting materials, offering a safer alternative to traditional methods. The procedure yields a highly pure oxamide precipitate within 2 days. By optimizing key reaction parameters including temperature, ascorbic acid/ammonia ratio, and ammonia concentration, the precipitation yield can be finely tuned. The resulting oxamide was comprehensively characterized by X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), and one-dimensional/two-dimensional (1D/2D) nuclear magnetic resonance (NMR). Concurrently, the liquid supernatant was analyzed by EDX, NMR, and mass spectrometry (MS), revealing the bioactive metabolite l-threonic acid as the sole major byproduct, with no other toxic compounds detected.

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Cite

BibTeXRIS
BibTeX
@article{mascolo2026ecofriendly,
  title = {{Eco-friendly One-Pot Synthesis of Oxamide.}},
  author = {Maria Cristina Mascolo and Laura Grauso and Nicola Di Costanzo and Pasquale Gallo and Virginia Lanzotti},
  journal = {ACS omega},
  year = {2026},
  month = sep,
  doi = {10.1021/acsomega.6c05095},
  url = {https://europepmc.org/article/MED/42948466},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Eco-friendly One-Pot Synthesis of Oxamide.
AU  - Maria Cristina Mascolo
AU  - Laura Grauso
AU  - Nicola Di Costanzo
AU  - Pasquale Gallo
AU  - Virginia Lanzotti
PY  - 2026
DA  - 2026/09/25
JO  - ACS omega
DO  - 10.1021/acsomega.6c05095
UR  - https://europepmc.org/article/MED/42948466
AB  - A novel, eco-friendly one-pot synthesis of oxamide was developed using nontoxic starting materials, offering a safer alternative to traditional methods. The procedure yields a highly pure oxamide precipitate within 2 days. By optimizing key reaction parameters including temperature, ascorbic acid/ammonia ratio, and ammonia concentration, the precipitation yield can be finely tuned. The resulting oxamide was comprehensively characterized by X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), and one-dimensional/two-dimensional (1D/2D) nuclear magnetic resonance (NMR). Concurrently, the liquid supernatant was analyzed by EDX, NMR, and mass spectrometry (MS), revealing the bioactive metabolite l-threonic acid as the sole major byproduct, with no other toxic compounds detected.
SN  - 2470-1343
ER  -