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Peer-reviewedCC BY-NC-NDRespirology case reports

Pulmonary Hamartoma Diagnosed by Transbronchial Mediastinal Cryobiopsy Additional to Needle Aspiration: A Case Report

  • Xin-Yi Shou1
  • Wan-Lei Fu2
  • Zan-Sheng Huang1
  • Shuo-Xin Zhang1
  • Jing Zhao3
  • Jing Zhang1
  • Felix J F Herth4
  • Ye Fan1
4 affiliations
  1. 1Department of Respiratory Disease Xinqiao Hospital, Third Military Medical University Chongqing China.
  2. 2Department of Pathology Xinqiao Hospital, Third Military Medical University Chongqing China.
  3. 3Department of Clinical Skills Training Center Xinqiao Hospital, Third Military Medical University Chongqing China.
  4. 4Department of Pneumology and Critical Care Medicine Thoraxklinik, and Translational Lung Research Center Heidelberg, University of Heidelberg Heidelberg Germany.
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Abstract

Pulmonary hamartoma presenting as a peribronchial lesion mimicking lymphadenopathy is diagnostically challenging, necessitating an adequate biopsy to establish a histopathological diagnosis. Here, we report a 55-year-old female non-smoker, 1 month after right renal cell carcinoma resection, who had a 24 × 21 mm peribronchial lesion in the left interlobar region on chest CT, initially interpreted as an enlarged lymph node. EBUS-TBNA yielded only cartilage and respiratory epithelium, while transbronchial mediastinal cryobiopsy (TBMC) yielded cartilage, adipose tissue, and epithelium-lined clefts, eventually establishing the diagnosis of a pulmonary hamartoma. At the 4-month follow-up, the patient reported only a slight cough, and the lesion remained stable on CT. This case presents the successful diagnosis of a pulmonary hamartoma using TBMC as an adjunct to conventional EBUS-TBNA.

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Cite

BibTeXRIS
BibTeX
@article{shou2026pulmonary,
  title = {{Pulmonary Hamartoma Diagnosed by Transbronchial Mediastinal Cryobiopsy Additional to Needle Aspiration: A Case Report}},
  author = {Xin-Yi Shou and Wan-Lei Fu and Zan-Sheng Huang and Shuo-Xin Zhang and Jing Zhao and Jing Zhang and Felix J F Herth and Ye Fan},
  journal = {Respirology case reports},
  year = {2026},
  month = oct,
  doi = {10.1002/rcr2.70788},
  url = {https://europepmc.org/article/PMC/PMC13716932},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Pulmonary Hamartoma Diagnosed by Transbronchial Mediastinal Cryobiopsy Additional to Needle Aspiration: A Case Report
AU  - Xin-Yi Shou
AU  - Wan-Lei Fu
AU  - Zan-Sheng Huang
AU  - Shuo-Xin Zhang
AU  - Jing Zhao
AU  - Jing Zhang
AU  - Felix J F Herth
AU  - Ye Fan
PY  - 2026
DA  - 2026/10/28
JO  - Respirology case reports
DO  - 10.1002/rcr2.70788
UR  - https://europepmc.org/article/PMC/PMC13716932
AB  - Pulmonary hamartoma presenting as a peribronchial lesion mimicking lymphadenopathy is diagnostically challenging, necessitating an adequate biopsy to establish a histopathological diagnosis. Here, we report a 55-year-old female non-smoker, 1 month after right renal cell carcinoma resection, who had a 24 × 21 mm peribronchial lesion in the left interlobar region on chest CT, initially interpreted as an enlarged lymph node. EBUS-TBNA yielded only cartilage and respiratory epithelium, while transbronchial mediastinal cryobiopsy (TBMC) yielded cartilage, adipose tissue, and epithelium-lined clefts, eventually establishing the diagnosis of a pulmonary hamartoma. At the 4-month follow-up, the patient reported only a slight cough, and the lesion remained stable on CT. This case presents the successful diagnosis of a pulmonary hamartoma using TBMC as an adjunct to conventional EBUS-TBNA.
SN  - 2051-3380
ER  -