Peer-reviewedCC BY-NC-NDInternal Medicine
Eosinophilic Bronchiolitis Diagnosed by a Transbronchial Lung Cryobiopsy and Successfully Treated with Biologic Agents: A Report of Two Cases and Literature Review
Abstract
Eosinophilic bronchiolitis (EB) is a rare airway disease characterized by eosinophilic bronchiolar inflammation. We herein report two cases of EB diagnosed by a transbronchial lung cryobiopsy (TBLC), a less invasive diagnostic procedure than a surgical biopsy. Two patients with a history of refractory asthma responded to treatment with oral corticosteroids and biologic agents. To our knowledge, these are among the first reported cases of EB that were successfully managed with dupilumab and benralizumab. These cases underscore the diagnostic utility of TBLCs and suggest the potential use of biologic agents as corticosteroid-sparing options for EB.
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BibTeX
@article{itogawa2026eosinophilic,
title = {{Eosinophilic Bronchiolitis Diagnosed by a Transbronchial Lung Cryobiopsy and Successfully Treated with Biologic Agents: A Report of Two Cases and Literature Review}},
author = {Katsuhiro Itogawa and Masako Amano and Daisuke Nakatani and Hiroki Ohta and Kenji Kusano and Tomohiro Oba and Rie Kawabe and Hideaki Yamakawa and Shintaro Sato and Keiichi Akasaka and Akiko Adachi and Tamiko Takemura and Hidekazu Matsushima},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.6267-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6267-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Eosinophilic Bronchiolitis Diagnosed by a Transbronchial Lung Cryobiopsy and Successfully Treated with Biologic Agents: A Report of Two Cases and Literature Review
AU - Katsuhiro Itogawa
AU - Masako Amano
AU - Daisuke Nakatani
AU - Hiroki Ohta
AU - Kenji Kusano
AU - Tomohiro Oba
AU - Rie Kawabe
AU - Hideaki Yamakawa
AU - Shintaro Sato
AU - Keiichi Akasaka
AU - Akiko Adachi
AU - Tamiko Takemura
AU - Hidekazu Matsushima
PY - 2026
DA - 2026/09/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.6267-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6267-25/_article
AB - Eosinophilic bronchiolitis (EB) is a rare airway disease characterized by eosinophilic bronchiolar inflammation. We herein report two cases of EB diagnosed by a transbronchial lung cryobiopsy (TBLC), a less invasive diagnostic procedure than a surgical biopsy. Two patients with a history of refractory asthma responded to treatment with oral corticosteroids and biologic agents. To our knowledge, these are among the first reported cases of EB that were successfully managed with dupilumab and benralizumab. These cases underscore the diagnostic utility of TBLCs and suggest the potential use of biologic agents as corticosteroid-sparing options for EB.
SN - 1349-7235
SN - 0918-2918
ER -