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Peer-reviewedCC BYScience Advances

Chromatin interaction landscape of epimorphic regeneration in teleost fish

  • Xiaohui Jia1,2
  • Xianglei Zhang2,3
  • Weifeng Lin2,3
  • Tengfei Ren2,3
  • Shiqi Liu2,4
  • Yufei Lou2,3
  • Wei Wang2,3
4 affiliations
  1. 1College of Biological Sciences, China Agricultural University, Beijing 100083, China.
  2. 2National Institute of Biological Sciences, Beijing 102206, China.
  3. 3Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China.
  4. 4Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Open at sourceDOICite

Abstract

Reorganization of chromatin architecture—including chromatin loops, topologically associating domains (TADs), and A/B compartments—has been increasingly linked to development and cell differentiation. However, how chromatin architecture reorganizes during the shift from homeostasis to regeneration remains poorly characterized. Here, we used zebrafish fin regeneration as a model to systematically investigate, via micro-C, the chromatin architecture associated with blastema formation. Our analyses unveiled that the alteration of chromatin looping upon amputation was dominant compared with that of TADs and compartments. Genes directly linked to injury-altered loop interactions, including essential regeneration regulators, were mainly related to morphogenesis and cell division. A side-by-side comparison between zebrafish and African killifish uncovered conserved and species-specific chromatin reorganization following injury. Notably, perturbing injury-altered loop interactions at the il11a locus suppressed its expression and impaired fin regeneration efficiency. Further, CTCF/CTCFL and Atf7 binding motifs were the top shared motifs enriched in regeneration-altered loop anchors. Our study uncovers the landscape of chromatin interactions during fin regeneration.

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Cite

BibTeXRIS
BibTeX
@article{jia2026chromatin,
  title = {{Chromatin interaction landscape of epimorphic regeneration in teleost fish}},
  author = {Xiaohui Jia and Xianglei Zhang and Weifeng Lin and Tengfei Ren and Shiqi Liu and Yufei Lou and Wei Wang},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aeh2087},
  url = {https://www.science.org/doi/10.1126/sciadv.aeh2087},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Chromatin interaction landscape of epimorphic regeneration in teleost fish
AU  - Xiaohui Jia
AU  - Xianglei Zhang
AU  - Weifeng Lin
AU  - Tengfei Ren
AU  - Shiqi Liu
AU  - Yufei Lou
AU  - Wei Wang
PY  - 2026
DA  - 2026/10/09
JO  - Science Advances
DO  - 10.1126/sciadv.aeh2087
UR  - https://www.science.org/doi/10.1126/sciadv.aeh2087
AB  - Reorganization of chromatin architecture—including chromatin loops, topologically associating domains (TADs), and A/B compartments—has been increasingly linked to development and cell differentiation. However, how chromatin architecture reorganizes during the shift from homeostasis to regeneration remains poorly characterized. Here, we used zebrafish fin regeneration as a model to systematically investigate, via micro-C, the chromatin architecture associated with blastema formation. Our analyses unveiled that the alteration of chromatin looping upon amputation was dominant compared with that of TADs and compartments. Genes directly linked to injury-altered loop interactions, including essential regeneration regulators, were mainly related to morphogenesis and cell division. A side-by-side comparison between zebrafish and African killifish uncovered conserved and species-specific chromatin reorganization following injury. Notably, perturbing injury-altered loop interactions at the il11a locus suppressed its expression and impaired fin regeneration efficiency. Further, CTCF/CTCFL and Atf7 binding motifs were the top shared motifs enriched in regeneration-altered loop anchors. Our study uncovers the landscape of chromatin interactions during fin regeneration.
SN  - 2375-2548
ER  -