Chemical profiling and in silico evaluation of a Matricaria chamomilla L. extract: exploring its antioxidant, antibacterial, antidiabetic, anti-inflammatory, and anticholinergic activities
Abstract
Introduction: This study aimed to investigate the phytochemical composition and multifunctional therapeutic potential of a hydroethanolic extract of Matricaria chamomilla L. collected from the semi-arid region of Algeria. The research focused on evaluating its antioxidant, antimicrobial, antidiabetic, antiinflammatory, neuroprotective, and potential anticancer activities. Methods: Total polyphenol and flavonoid contents were determined using spectrophotometric methods. The phytochemical profile was characterized by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Antioxidant activity was assessed using DPPH and galvinoxyl radical scavenging assays. Antimicrobial activity was evaluated against bacterial and fungal strains using inhibition zone measurements. Enzyme inhibitory activities against α-amylase, acetylcholinesterase, and butyrylcholinesterase were investigated in vitro. Anti-inflammatory activity was evaluated through protein denaturation inhibition and carrageenan-induced paw edema assays. Molecular docking studies were performed to assess the interactions of identified compounds with breast cancer targets ERα and HER2.
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BibTeX
@article{ferhat2026chemical,
title = {{Chemical profiling and in silico evaluation of a Matricaria chamomilla L. extract: exploring its antioxidant, antibacterial, antidiabetic, anti-inflammatory, and anticholinergic activities}},
author = {Abderrazek Ferhat and Mohammed Messaoudi and Khalil Guelifet and Ilham Ben Amor and Wafa Zahnit and Khadra Afaf Bendrihem and Azzeddine Zeraib and Hamza Ouakouak and Mokhtar Benmohamed and Mohamed Amine Ferhat and Imane Larkem and Huda Alsaeedi and Aftab Aslam Parwaz Khan and Mikhael Bechelany and Furong Tian and Ahmed Barhoum},
journal = {Frontiers in Nutrition},
year = {2026},
month = jun,
doi = {10.3389/fnut.2026.1852820},
url = {https://hal.umontpellier.fr/hal-05770502v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Chemical profiling and in silico evaluation of a Matricaria chamomilla L. extract: exploring its antioxidant, antibacterial, antidiabetic, anti-inflammatory, and anticholinergic activities
AU - Abderrazek Ferhat
AU - Mohammed Messaoudi
AU - Khalil Guelifet
AU - Ilham Ben Amor
AU - Wafa Zahnit
AU - Khadra Afaf Bendrihem
AU - Azzeddine Zeraib
AU - Hamza Ouakouak
AU - Mokhtar Benmohamed
AU - Mohamed Amine Ferhat
AU - Imane Larkem
AU - Huda Alsaeedi
AU - Aftab Aslam Parwaz Khan
AU - Mikhael Bechelany
AU - Furong Tian
AU - Ahmed Barhoum
PY - 2026
DA - 2026/06/18
JO - Frontiers in Nutrition
DO - 10.3389/fnut.2026.1852820
UR - https://hal.umontpellier.fr/hal-05770502v1
AB - Introduction: This study aimed to investigate the phytochemical composition and multifunctional therapeutic potential of a hydroethanolic extract of Matricaria chamomilla L. collected from the semi-arid region of Algeria. The research focused on evaluating its antioxidant, antimicrobial, antidiabetic, antiinflammatory, neuroprotective, and potential anticancer activities. Methods: Total polyphenol and flavonoid contents were determined using spectrophotometric methods. The phytochemical profile was characterized by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Antioxidant activity was assessed using DPPH and galvinoxyl radical scavenging assays. Antimicrobial activity was evaluated against bacterial and fungal strains using inhibition zone measurements. Enzyme inhibitory activities against α-amylase, acetylcholinesterase, and butyrylcholinesterase were investigated in vitro. Anti-inflammatory activity was evaluated through protein denaturation inhibition and carrageenan-induced paw edema assays. Molecular docking studies were performed to assess the interactions of identified compounds with breast cancer targets ERα and HER2.
SN - 2296-861X
ER -