New depsidones from Garcinia parvifolia and their antidiabetic, anti-tyrosinase, and antioxidant activities.
10 affiliations
- 1Division of Exploration and Synthesis of Bioactive Compounds (ESBC), University CoE - Research Center for Bio-Molecule Engineering (BIOME), Universitas Airlangga Surabaya 60115 Indonesia.
- 2Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia [email protected].
- 3Plant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn University Bangkok 10330 Thailand.
- 4Department of Chemistry, Faculty of Science, Universiti Malaya Kuala Lumpur 50603 Malaysia.
- 5Faculty of Pharmacy, Ton Duc Thang University Ho Chi Minh City Vietnam.
- 6Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University Bangkok 10330 Thailand.
- 7Program in Bioinformatics and Computational Biology, College of Interdisciplinary and Integrative Studies, Chulalongkorn University Bangkok 10330 Thailand.
- 8Center of Excellent in Natural Products (CENP), Department of Chemistry, Faculty of Science, Chulalongkorn University Bangkok 10330 Thailand.
- 9Department of Chemistry, Faculty of Science and Technology, Thammasat University Lampang Campus Lampang 52190 Thailand.
- 10Environmental Office of Balikpapan Balikpapan 76115 East Kalimantan Indonesia.
Abstract
In the search for potent bioactive compounds derived from medicinal plants, Garcinia parvifolia from East Kalimantan has demonstrated significant bioactivity consistent with established scientific criteria. Bioassay-guided isolation of the fruit extract resulted in two new depsidones named methyl garcidepsidone B (1) and parvifoliricodone A (6), two known analogues, a phloroglucinol, and a furfural derivative. Their structures were determined by spectroscopic techniques. The isolated compounds were subjected to assessments for their potential antidiabetic effects through an α-glucosidase inhibition assay, anti-tyrosinase activity, and antioxidant properties. Out of the isolated compounds, methyl garcidepsidone B (1) was the most potent inhibitor against α-glucosidase compared with acarbose as a positive standard. In the antioxidant assay, all isolated compounds showed significant free radical scavenging activity against ABTS, with the exception of compound 4. Regarding tyrosinase inhibitory activity, all isolated compounds exhibited low enzyme inhibition activity. Additionally, in silico molecular docking studies showed that compounds 1-3 exhibited favorable conformation and binding affinities within the enzymatic pockets of α-glucosidase. These findings indicate that the indigenous G. parvifolia fruit may serve as a natural source of antidiabetic, antioxidant, and anti-tyrosinase compounds, with potential for further pharmacological investigation.
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BibTeX
@article{ramadhan2026depsidones,
title = {{New depsidones from Garcinia parvifolia and their antidiabetic, anti-tyrosinase, and antioxidant activities.}},
author = {Rico Ramadhan and Azeana Zahari and Irmayanti Tri Kurnia and Anh-Khoa Nguyen and Sehanat Prasongsuk and Yazdaniyar Fajri Halimi Firdaus and Thanyada Rungrotmongkol and Preecha Phuwapraisirisan and Dinda Ayu Lestari and Jirapast Sichaem and Kautsar Ul-Haq and Aziz Ahmad Bukhori and Devi Nawang Ariningtyas and Lukman Riyadi},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra06497c},
url = {https://europepmc.org/article/MED/42923738},
note = {CC BY},
}
RIS
TY - JOUR
TI - New depsidones from Garcinia parvifolia and their antidiabetic, anti-tyrosinase, and antioxidant activities.
AU - Rico Ramadhan
AU - Azeana Zahari
AU - Irmayanti Tri Kurnia
AU - Anh-Khoa Nguyen
AU - Sehanat Prasongsuk
AU - Yazdaniyar Fajri Halimi Firdaus
AU - Thanyada Rungrotmongkol
AU - Preecha Phuwapraisirisan
AU - Dinda Ayu Lestari
AU - Jirapast Sichaem
AU - Kautsar Ul-Haq
AU - Aziz Ahmad Bukhori
AU - Devi Nawang Ariningtyas
AU - Lukman Riyadi
PY - 2026
DA - 2026/10/22
JO - RSC advances
DO - 10.1039/d6ra06497c
UR - https://europepmc.org/article/MED/42923738
AB - In the search for potent bioactive compounds derived from medicinal plants, Garcinia parvifolia from East Kalimantan has demonstrated significant bioactivity consistent with established scientific criteria. Bioassay-guided isolation of the fruit extract resulted in two new depsidones named methyl garcidepsidone B (1) and parvifoliricodone A (6), two known analogues, a phloroglucinol, and a furfural derivative. Their structures were determined by spectroscopic techniques. The isolated compounds were subjected to assessments for their potential antidiabetic effects through an α-glucosidase inhibition assay, anti-tyrosinase activity, and antioxidant properties. Out of the isolated compounds, methyl garcidepsidone B (1) was the most potent inhibitor against α-glucosidase compared with acarbose as a positive standard. In the antioxidant assay, all isolated compounds showed significant free radical scavenging activity against ABTS, with the exception of compound 4. Regarding tyrosinase inhibitory activity, all isolated compounds exhibited low enzyme inhibition activity. Additionally, in silico molecular docking studies showed that compounds 1-3 exhibited favorable conformation and binding affinities within the enzymatic pockets of α-glucosidase. These findings indicate that the indigenous G. parvifolia fruit may serve as a natural source of antidiabetic, antioxidant, and anti-tyrosinase compounds, with potential for further pharmacological investigation.
SN - 2046-2069
ER -