Effects of time-restricted eating on body composition,glucose and lipid metabolism,and reproductive endocrinology in patients with overweight/obese polycystic ovary syndrome

@article{jiaqian2026effects,
  title = {{Effects of time-restricted eating on body composition,glucose and lipid metabolism,and reproductive endocrinology in patients with overweight/obese polycystic ovary syndrome}},
  author = {HUANG Jiaqian and SHI Shanping and CHEN Chen},
  journal = {Zhongguo linchuang yanjiu},
  year = {2026},
  month = oct,
  doi = {10.13429/j.cnki.cjcr.2026.10.022},
  url = {https://doi.org/10.13429/j.cnki.cjcr.2026.10.022},
  note = {CC BY-NC-ND},
}

TY  - JOUR
TI  - Effects of time-restricted eating on body composition,glucose and lipid metabolism,and reproductive endocrinology in patients with overweight/obese polycystic ovary syndrome
AU  - HUANG Jiaqian
AU  - SHI Shanping
AU  - CHEN Chen
PY  - 2026
DA  - 2026/10/26
JO  - Zhongguo linchuang yanjiu
DO  - 10.13429/j.cnki.cjcr.2026.10.022
UR  - https://doi.org/10.13429/j.cnki.cjcr.2026.10.022
AB  - Objective To evaluate the short-term effects of a 5-week daily 8-hour time-restricted eating(TRE)regimen on body composition,glucose and lipid metabolism and reproductive endocrine function in overweight/obese women with polycystic ovary syndrome (PCOS),and to explore the clinical significance of whole-body phase angle(PhA). Methods A single-center,single-arm,self-controlled before-after study was conducted. Eighteen reproductive-aged women with PCOS and body mass index(BMI)≥24 kg/m2 from 2024 to 2025 were enrolled and received 5-week daily 8-hour TRE. Anthropometric parameters,body composition,oral glucose tolerance test(OGTT)indicators［plasma glucose(PG),serum insulin,C-peptide］,serum hemoglobin A1C(HbA1C),lipid profile and reproductive endocrine hormones were measured before and after the intervention. Paired t-test or Wilcoxon signed-rank test was used for pre-intervention and post-intervention comparison,and generalized estimating equations(GEE)were applied to analyze serial OGTT data at multiple time points. With the change in PhA (ΔPhA)before and after intervention as the dependent variable (17 patients included in this analysis),univariate and multivariate linear regression analyses were performed after dimensionality reduction of 37 change indicators via principal component analysis(PCA). Results After 5-week daily 8-hour TRE intervention,body mass,BMI,waist circumference,waist-to-hip ratio,fat mass,body fat percentage and visceral fat area all decreased significantly(P<0.05),while no significant changes were observed in skeletal muscle mass and PhA(P>0.05). Levels of HbA1C,homeostasis model assessment of insulin resistance(HOMA-IR),as well as overall PG,insulin and C-peptide at multiple OGTT time points all decreased.GEE analysis revealed significant inter-time effects,pre-and post-intervention effects and interaction effects for PG,insulin and C-peptide during OGTT(P<0.01). Triglycerides,small dense low-density lipoprotein cholesterol(sdLDL-C)and lipoprotein-associated phospholipase A2 decreased significantly(P<0.05). Most gonadal axis hormones showed no significant changes,except for a mild elevation in 17-hydroxyprogesterone. Nine principal components were retained after PCA,accounting for 88.27% of the total variance. Multivariate linear regression analysis showed that PC1(mainly driven by changes in waist circumference,fat mass,visceral fat area,total cholesterol and low density lipoprotein cholesterol)and PC3(mainly driven by changes in sdLDL-C,BMI,fasting plasma glucose,HbA1C and several reproductive endocrine indicators)were independently associated with ΔPhA(β =- 0.049,P=0.003; β =- 0.068,P=0.001). Conclusion A 5-week daily 8-hour TRE regimen can improve body composition,glucose metabolism and atherogenic lipid profiles in overweight/obese women with PCOS without strict caloric restriction. Changes in PhA may reflect the comprehensive effects of multidimensional improvements in body composition and metabolic status.
SN  - 1674-8182
ER  -