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Peer-reviewedCC BYInternational Journal of Molecular Sciences

Molecular Mechanisms Underlying Alzheimer’s Disease Pathogenesis: Comprehensive Overview

  • Filomena Lo Vecchio1
  • Annamaria la Torre1
  • Carolina Gravina1
  • Grazia D’Onofrio2
  • A Greco3
  1. 1Laboratory of Gerontology and Geriatrics, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
  2. 2Clinical Psychology Service, Health Department, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
  3. 3Complex Unit of Geriatrics, Department of Medical Sciences, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
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Abstract

Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder ranking first as cause of dementia in the elderly. It is characterized by the progressive deterioration of the central nervous system, leading to impaired cognitive function and reduced ability to perform daily activities. Pathological hallmarks of AD include the accumulation of β-amyloid plaques and neurofibrillary tangles which ultimately cause neuronal death and synaptic loss. The vast majority of AD cases are sporadic, with aging representing the primary non-modifiable risk factor contributing to disease susceptibility and progression. However, several factors encompassing genetic predisposition, systemic inflammation, chronic diseases, infections, traumatic brain injury, lifestyle factors, and environmental exposures may affect AD onset. This work aims to describe and discuss the main molecular pathways involved in AD pathophysiology and to examine how these mechanisms cross-interact in promoting neurodegeneration and disease progression.

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Cite

BibTeXRIS
BibTeX
@article{vecchio2026molecular,
  title = {{Molecular Mechanisms Underlying Alzheimer’s Disease Pathogenesis: Comprehensive Overview}},
  author = {Filomena Lo Vecchio and Annamaria la Torre and Carolina Gravina and Grazia D’Onofrio and A Greco},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = may,
  doi = {10.3390/ijms27104651},
  url = {https://doi.org/10.3390/ijms27104651},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Molecular Mechanisms Underlying Alzheimer’s Disease Pathogenesis: Comprehensive Overview
AU  - Filomena Lo Vecchio
AU  - Annamaria la Torre
AU  - Carolina Gravina
AU  - Grazia D’Onofrio
AU  - A Greco
PY  - 2026
DA  - 2026/05/21
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27104651
UR  - https://doi.org/10.3390/ijms27104651
AB  - Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder ranking first as cause of dementia in the elderly. It is characterized by the progressive deterioration of the central nervous system, leading to impaired cognitive function and reduced ability to perform daily activities. Pathological hallmarks of AD include the accumulation of β-amyloid plaques and neurofibrillary tangles which ultimately cause neuronal death and synaptic loss. The vast majority of AD cases are sporadic, with aging representing the primary non-modifiable risk factor contributing to disease susceptibility and progression. However, several factors encompassing genetic predisposition, systemic inflammation, chronic diseases, infections, traumatic brain injury, lifestyle factors, and environmental exposures may affect AD onset. This work aims to describe and discuss the main molecular pathways involved in AD pathophysiology and to examine how these mechanisms cross-interact in promoting neurodegeneration and disease progression.
SN  - 1422-0067
SN  - 1661-6596
ER  -