Molecular Mechanisms Underlying Cucumber Resistance to Cucumber Green Mottle Mosaic Virus: From Host-Virus Interactions to Precision Breeding Strategies.
- 1College of Horticulture, Northeast Agricultural University, Harbin 150030, China.
- 2Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Abstract
Cucumber (Cucumis sativus L.) is an economically important vegetable crop cultivated worldwide, but its sustainable production is increasingly threatened by Cucumber green mottle mosaic virus (CGMMV). CGMMV is a positive-sense single-stranded RNA virus belonging to the genus Tobamovirus and represents a major constraint on cucurbit production because of its efficient seed transmission, mechanical spread, environmental persistence, and broad host range. Infection can cause leaf mosaic and mottling, growth suppression, and severe fruit symptoms, including internal discoloration, water-soaked tissues, and flesh deterioration, resulting in substantial losses in yield and commercial quality. Recent advances in cucumber genomics, resistance-germplasm screening, host-virus interaction studies, and molecular breeding have provided new opportunities for improving CGMMV resistance. However, progress remains constrained by the scarcity of well-characterized resistance donors, the limited functional validation of cucumber-specific resistance genes, isolate-dependent resistance responses, and the relatively low efficiency of cucumber transformation and genome editing. This review summarizes current knowledge of CGMMV infection processes, host susceptibility factors, antiviral defense pathways, resistance resources, and resistance-associated loci in cucumber and related cucurbits. Evidence is interpreted according to host species and the level of experimental validation. It further evaluates the potential of marker-assisted selection, genomic selection, genome editing, and RNA-based engineering and outlines an integrated framework for translating molecular findings into durable CGMMV-resistant cucumber cultivars.
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BibTeX
@article{yu2026molecular,
title = {{Molecular Mechanisms Underlying Cucumber Resistance to Cucumber Green Mottle Mosaic Virus: From Host-Virus Interactions to Precision Breeding Strategies.}},
author = {Xiaoting Yu and Yuqiang Zhu and Xin Wang and Yuyan Sun and Luyao Gao and Shengjun Zhou and Ming Xin and Peng Zhang},
journal = {International journal of molecular sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198569},
url = {https://europepmc.org/article/MED/42883816},
note = {CC BY},
}
RIS
TY - JOUR
TI - Molecular Mechanisms Underlying Cucumber Resistance to Cucumber Green Mottle Mosaic Virus: From Host-Virus Interactions to Precision Breeding Strategies.
AU - Xiaoting Yu
AU - Yuqiang Zhu
AU - Xin Wang
AU - Yuyan Sun
AU - Luyao Gao
AU - Shengjun Zhou
AU - Ming Xin
AU - Peng Zhang
PY - 2026
DA - 2026/09/25
JO - International journal of molecular sciences
DO - 10.3390/ijms27198569
UR - https://europepmc.org/article/MED/42883816
AB - Cucumber (Cucumis sativus L.) is an economically important vegetable crop cultivated worldwide, but its sustainable production is increasingly threatened by Cucumber green mottle mosaic virus (CGMMV). CGMMV is a positive-sense single-stranded RNA virus belonging to the genus Tobamovirus and represents a major constraint on cucurbit production because of its efficient seed transmission, mechanical spread, environmental persistence, and broad host range. Infection can cause leaf mosaic and mottling, growth suppression, and severe fruit symptoms, including internal discoloration, water-soaked tissues, and flesh deterioration, resulting in substantial losses in yield and commercial quality. Recent advances in cucumber genomics, resistance-germplasm screening, host-virus interaction studies, and molecular breeding have provided new opportunities for improving CGMMV resistance. However, progress remains constrained by the scarcity of well-characterized resistance donors, the limited functional validation of cucumber-specific resistance genes, isolate-dependent resistance responses, and the relatively low efficiency of cucumber transformation and genome editing. This review summarizes current knowledge of CGMMV infection processes, host susceptibility factors, antiviral defense pathways, resistance resources, and resistance-associated loci in cucumber and related cucurbits. Evidence is interpreted according to host species and the level of experimental validation. It further evaluates the potential of marker-assisted selection, genomic selection, genome editing, and RNA-based engineering and outlines an integrated framework for translating molecular findings into durable CGMMV-resistant cucumber cultivars.
SN - 1422-0067
ER -