The Association Between Magnesium Depletion Score and Depression Among Men in Central Sudan: A Community-Based Cross-Sectional Study.
5 affiliations
- 1Faculty of Medicine and Health Sciences University of Gadarif Gadarif Sudan.
- 2Department of Psychiatry College of Medicine Qassim University Buraydah Qassim Saudi Arabia.
- 3Department of Family and Community Medicine College of Medicine Qassim University Buraydah Saudi Arabia.
- 4Department of Medicine College of Medicine Taif University Saudi Arabia.
- 5Department of Obstetrics and Gynecology College of Medicine Qassim University Buraydah Qassim Saudi Arabia.
Abstract
Background and aim
Depression is a global public health concern with significant morbidity and mortality. There are a few published reports on the association between the magnesium depletion score (MDS) and depression. In this study, we aimed to assess the level of association between MDS and depression among men in central Sudan.Methods
A multistage community-based cross-sectional survey included adult men in central Sudan from April to June 2025. A face-to-face interview was used to collect sociodemographic data and medical history. The Patient Health Questionnaire-9 (PHQ-9) was used to assess depression among men. The MDS was computed. Binary multivariable and modified Poisson regression analyses were performed.Results
Three hundred and twelve men were enrolled. Their median (IQR) age was 50.0 (34.0-64.0) years. Multivariable Poisson analysis showed a positive association between the MDS and the PHQ-9 score when entering the MDS as either a continuous variable (adjusted relative risk [ARR] = 1.23, 95% confidence interval [CI] = 1.15-1.31) or a categorical variable (the ARR for medium and high MDS were 1.41 (95% CI = 1.23-1.61) and 2.09 (95% CI = 1.60-2.73), respectively). Multivariable binary regression showed a positive association between MDS (continuous) and depression, with an adjusted odds ratio (AOR) of 2.80 (95% CI = 1.35-3.00) and depression. Likewise, medium (AOR = 2.80, 95% CI = 1.28-6.10) and high (AOR = 16.71, 95% CI = 3.91-71.33) MDS were associated with depression.Conclusion
This study showed a positive association between MDS and depression, indicating a need to further assess the possibility of MDS in depression.
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BibTeX
@article{omar2026association,
title = {{The Association Between Magnesium Depletion Score and Depression Among Men in Central Sudan: A Community-Based Cross-Sectional Study.}},
author = {Saeed M Omar and Hatim Y Alharbi and Afnan A Alwabili and Eman A Alotaibi and Sami S Alharthi and Ishag Adam},
journal = {Health science reports},
year = {2026},
month = oct,
doi = {10.1002/hsr2.73448},
url = {https://europepmc.org/article/MED/42948164},
note = {CC BY},
}
RIS
TY - JOUR
TI - The Association Between Magnesium Depletion Score and Depression Among Men in Central Sudan: A Community-Based Cross-Sectional Study.
AU - Saeed M Omar
AU - Hatim Y Alharbi
AU - Afnan A Alwabili
AU - Eman A Alotaibi
AU - Sami S Alharthi
AU - Ishag Adam
PY - 2026
DA - 2026/10/27
JO - Health science reports
DO - 10.1002/hsr2.73448
UR - https://europepmc.org/article/MED/42948164
AB - Background and aim Depression is a global public health concern with significant morbidity and mortality. There are a few published reports on the association between the magnesium depletion score (MDS) and depression. In this study, we aimed to assess the level of association between MDS and depression among men in central Sudan.Methods A multistage community-based cross-sectional survey included adult men in central Sudan from April to June 2025. A face-to-face interview was used to collect sociodemographic data and medical history. The Patient Health Questionnaire-9 (PHQ-9) was used to assess depression among men. The MDS was computed. Binary multivariable and modified Poisson regression analyses were performed.Results Three hundred and twelve men were enrolled. Their median (IQR) age was 50.0 (34.0-64.0) years. Multivariable Poisson analysis showed a positive association between the MDS and the PHQ-9 score when entering the MDS as either a continuous variable (adjusted relative risk [ARR] = 1.23, 95% confidence interval [CI] = 1.15-1.31) or a categorical variable (the ARR for medium and high MDS were 1.41 (95% CI = 1.23-1.61) and 2.09 (95% CI = 1.60-2.73), respectively). Multivariable binary regression showed a positive association between MDS (continuous) and depression, with an adjusted odds ratio (AOR) of 2.80 (95% CI = 1.35-3.00) and depression. Likewise, medium (AOR = 2.80, 95% CI = 1.28-6.10) and high (AOR = 16.71, 95% CI = 3.91-71.33) MDS were associated with depression.Conclusion This study showed a positive association between MDS and depression, indicating a need to further assess the possibility of MDS in depression.
SN - 2398-8835
ER -