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Peer-reviewedCC BY 4.0ACS Omega

Nanostructured Hybrid Matrix Device: An Engineered Approach for Localized Photodynamic Therapy in 9L/lacZ Cell Models

  • Jéssica A. R. Ambrósio1
  • Janicy A. Carvalho1
  • Letícia G. M. Pinto1
  • Leandro J. Raniero1
  • Vitor L. M. Marmo1
  • Juliana G. Pinto1
  • Tassia J. Martins1
  • Juliana Ferreira-Strixino1
  • Milton Beltrame Júnior1
  • Andreza R. Simioni1
  1. 1Universidade do Vale do Paraiba , , ,
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Abstract

Gliosarcoma treatment remains a challenge due to its aggressiveness and high recurrence rates. This study describes the development and characterization of a novel hybrid drug delivery system (DDS) for localized photodynamic therapy (PDT). The system consists of a PVA/gelatin hydrogel encapsulated with hydroxyapatite microspheres (meHAp) loaded with chloroaluminum phthalocyanine (ClAlPc). SEM and FTIR analysis confirmed the successful incorporation of meHAp into the porous 3D polymeric network. The addition of meHAp increased the matrix’s structural rigidity, adjusting the swelling degree and enabling a more controlled release of the photosensitizer (45% vs 94% in the control). Biological assays on 9L/lacZ gliosarcoma cells revealed high internalization and a 98% reduction in cell viability under PDT protocols. These results suggest that the meHAp-reinforced hydrogel system is a promising option for the localized treatment of brain tumors, providing a modified release of the photosensitizer.

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Cite

BibTeXRIS
BibTeX
@article{ambrosio2026nanostructured,
  title = {{Nanostructured Hybrid Matrix Device: An Engineered Approach for Localized Photodynamic Therapy in 9L/lacZ Cell Models}},
  author = {Jéssica A. R. Ambrósio and Janicy A. Carvalho and Letícia G. M. Pinto and Leandro J. Raniero and Vitor L. M. Marmo and Juliana G. Pinto and Tassia J. Martins and Juliana Ferreira-Strixino and Milton Beltrame Júnior and Andreza R. Simioni},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c04974},
  url = {https://pubs.acs.org/acsodf/article/11/42/64712/5450446/Nanostructured-Hybrid-Matrix-Device-An-Engineered},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Nanostructured Hybrid Matrix Device: An Engineered Approach for Localized Photodynamic Therapy in 9L/lacZ Cell Models
AU  - Jéssica A. R. Ambrósio
AU  - Janicy A. Carvalho
AU  - Letícia G. M. Pinto
AU  - Leandro J. Raniero
AU  - Vitor L. M. Marmo
AU  - Juliana G. Pinto
AU  - Tassia J. Martins
AU  - Juliana Ferreira-Strixino
AU  - Milton Beltrame Júnior
AU  - Andreza R. Simioni
PY  - 2026
DA  - 2026/10/13
JO  - ACS Omega
DO  - 10.1021/acsomega.6c04974
UR  - https://pubs.acs.org/acsodf/article/11/42/64712/5450446/Nanostructured-Hybrid-Matrix-Device-An-Engineered
AB  - Gliosarcoma treatment remains a challenge due to its aggressiveness and high recurrence rates. This study describes the development and characterization of a novel hybrid drug delivery system (DDS) for localized photodynamic therapy (PDT). The system consists of a PVA/gelatin hydrogel encapsulated with hydroxyapatite microspheres (meHAp) loaded with chloroaluminum phthalocyanine (ClAlPc). SEM and FTIR analysis confirmed the successful incorporation of meHAp into the porous 3D polymeric network. The addition of meHAp increased the matrix’s structural rigidity, adjusting the swelling degree and enabling a more controlled release of the photosensitizer (45% vs 94% in the control). Biological assays on 9L/lacZ gliosarcoma cells revealed high internalization and a 98% reduction in cell viability under PDT protocols. These results suggest that the meHAp-reinforced hydrogel system is a promising option for the localized treatment of brain tumors, providing a modified release of the photosensitizer.
SN  - 2470-1343
ER  -