Short-term prediction of COPD exacerbations based on wearable vital sign monitoring
Abstract
Early detection of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains a critical challenge in COPD management. This study introduces the Bora Vital Sign Standard Score (BVS3), a novel unsupervised statistical score that predicts AECOPD using vital signs collected at home through remote patient monitoring, and retrospectively evaluates its predictive performance in identifying AECOPD ahead of clinician-defined episodes. The eMEUSE-SANTÉ clinical trial (NCT04963192) involved 220 COPD patients who were remotely monitored for six months using a CE-certified (Class IIa) connected wristband measuring oxygen saturation (SpO₂), breathing rate (BR) and heart rate (HR). A total of 42 physician validated exacerbations of COPD with no missing remote monitoring data were documented in 39 patients at a general hospital. Continuous 24-hour monitoring of vital signs using a connected wristband was well accepted over the long term, with a median adherence of 86% indicating strong patient compliance. The BVS3 risk score achieved excellent predictive performance, with an AUC of 0.88 (95% CI 0.83 - 0.92) for moderate and severe AECOPD combined. The BVS3 score anticipated exacerbations an average of 4.4 ± 3.1 days before clinical confirmation, with an overall accuracy of 84.8% and sensitivity of 74% with 85% specificity. Individual Z-scores for heart rate (z-HR), breathing rate (z-BR) and oxygen saturation (z-SpO2) showed specific predictive capabilities for moderate and severe events, yielding AUCs of 0.83, 0.82 and 0.71 respectively, but with inferior performances compared with the combination of the 3 vital signs Z-scores. These results demonstrate that integrating passive remote monitoring with unsupervised statistical modeling provides a scalable, high-compliance approach to AECOPD detection. The interpretable BVS3 risk score achieves good accuracy and anticipation for AECOPD prediction with minimal patient burden. By enabling earlier intervention, this end-to-end digital solution could significantly improve patient outcomes through proactive disease management.
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BibTeX
@article{tilquin2026shortterm,
title = {{Short-term prediction of COPD exacerbations based on wearable vital sign monitoring}},
author = {Florian Tilquin and Sylvain Le Liepvre and Soumaya Balbolia and Marie Pirotais and Yann Le Guillou and Jean-Claude Cornu and Nicolas Roche and Gerard Criner and Marie Joyeux-Faure and Jean-Louis Pépin},
journal = {PLOS Digital Health},
year = {2026},
month = may,
doi = {10.1371/journal.pdig.0001405},
url = {https://hal.science/hal-05743898v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Short-term prediction of COPD exacerbations based on wearable vital sign monitoring
AU - Florian Tilquin
AU - Sylvain Le Liepvre
AU - Soumaya Balbolia
AU - Marie Pirotais
AU - Yann Le Guillou
AU - Jean-Claude Cornu
AU - Nicolas Roche
AU - Gerard Criner
AU - Marie Joyeux-Faure
AU - Jean-Louis Pépin
PY - 2026
DA - 2026/05/28
JO - PLOS Digital Health
DO - 10.1371/journal.pdig.0001405
UR - https://hal.science/hal-05743898v1
AB - Early detection of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains a critical challenge in COPD management. This study introduces the Bora Vital Sign Standard Score (BVS3), a novel unsupervised statistical score that predicts AECOPD using vital signs collected at home through remote patient monitoring, and retrospectively evaluates its predictive performance in identifying AECOPD ahead of clinician-defined episodes. The eMEUSE-SANTÉ clinical trial (NCT04963192) involved 220 COPD patients who were remotely monitored for six months using a CE-certified (Class IIa) connected wristband measuring oxygen saturation (SpO₂), breathing rate (BR) and heart rate (HR). A total of 42 physician validated exacerbations of COPD with no missing remote monitoring data were documented in 39 patients at a general hospital. Continuous 24-hour monitoring of vital signs using a connected wristband was well accepted over the long term, with a median adherence of 86% indicating strong patient compliance. The BVS3 risk score achieved excellent predictive performance, with an AUC of 0.88 (95% CI 0.83 - 0.92) for moderate and severe AECOPD combined. The BVS3 score anticipated exacerbations an average of 4.4 ± 3.1 days before clinical confirmation, with an overall accuracy of 84.8% and sensitivity of 74% with 85% specificity. Individual Z-scores for heart rate (z-HR), breathing rate (z-BR) and oxygen saturation (z-SpO2) showed specific predictive capabilities for moderate and severe events, yielding AUCs of 0.83, 0.82 and 0.71 respectively, but with inferior performances compared with the combination of the 3 vital signs Z-scores. These results demonstrate that integrating passive remote monitoring with unsupervised statistical modeling provides a scalable, high-compliance approach to AECOPD detection. The interpretable BVS3 risk score achieves good accuracy and anticipation for AECOPD prediction with minimal patient burden. By enabling earlier intervention, this end-to-end digital solution could significantly improve patient outcomes through proactive disease management.
SN - 2767-3170
ER -