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Peer-reviewedCC BY 4.0Current Medical Imaging

MRI Features of Diffuse Glioneuronal Tumor with Oligodendroglioma-like features and Nuclear Clusters: A Case Report and Literature Review

  • Dabiao Deng1
  • Chongzhu Fan2
  • Yanying Yang3
  • Wensheng Wang1
  • Huafei Zhao1
  • Shougui Gao1
  1. 1Department of Imaging, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, Guangdong Province, China
  2. 2Department of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, Guangdong Province, China
  3. 3Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, Guangdong Province, China
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Abstract

Introduction: Accurate diagnosis of diffuse glioneuronal tumors with oligodendroglioma-like features and nuclear clusters (DGONC) remains challenging due to scarce clinical and imaging evidence. Further systematic studies are therefore needed to characterize this tumor entity.

Case Presentation: A 7-year-old boy presented with a 3-day history of headache and vomiting. Cranial Magnetic Resonance Imaging (MRI) revealed a well-circumscribed mass in the right temporal lobe with a ground-glass appearance and no contrast enhancement or restricted diffusion. After gross total resection, histopathology showed diffusely infiltrating oligodendroglioma-like cells accompanied by “pennies on a plate” multinucleated cells and nuclear clusters. DNA methylation profiling confirmed the diagnosis of DGONC (calibrated score, 0.99), and chromosomal copy number analysis demonstrated multiple chromosomal gains without monosomy 14. The patient received radiotherapy alone postoperatively and remained clinically stable at the 35.5-month follow-up. This case suggests that the discordance between high-grade histology and an indolent, low-grade radiological appearance is an important clinical feature of DGONC.

Conclusion: This case demonstrates that DGONC can present with non-epileptic onset and without monosomy 14. When a brain tumor exhibits characteristic histology yet a low-grade radiological appearance, DGONC should be considered and the diagnosis confirmed by methylation analysis. Treatment decisions must be made cautiously, based on the extent of surgical resection and histological features.

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Cite

BibTeXRIS
BibTeX
@article{deng2026features,
  title = {{MRI Features of Diffuse Glioneuronal Tumor with Oligodendroglioma-like features and Nuclear Clusters: A Case Report and Literature Review}},
  author = {Dabiao Deng and Chongzhu Fan and Yanying Yang and Wensheng Wang and Huafei Zhao and Shougui Gao},
  journal = {Current Medical Imaging},
  year = {2026},
  month = sep,
  doi = {10.2174/0115734056482743260824063132},
  url = {https://doi.org/10.2174/0115734056482743260824063132},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - MRI Features of Diffuse Glioneuronal Tumor with Oligodendroglioma-like features and Nuclear Clusters: A Case Report and Literature Review
AU  - Dabiao Deng
AU  - Chongzhu Fan
AU  - Yanying Yang
AU  - Wensheng Wang
AU  - Huafei Zhao
AU  - Shougui Gao
PY  - 2026
DA  - 2026/09/11
JO  - Current Medical Imaging
DO  - 10.2174/0115734056482743260824063132
UR  - https://doi.org/10.2174/0115734056482743260824063132
AB  - Introduction: Accurate diagnosis of diffuse glioneuronal tumors with oligodendroglioma-like features and nuclear clusters (DGONC) remains challenging due to scarce clinical and imaging evidence. Further systematic studies are therefore needed to characterize this tumor entity.  Case Presentation: A 7-year-old boy presented with a 3-day history of headache and vomiting. Cranial Magnetic Resonance Imaging (MRI) revealed a well-circumscribed mass in the right temporal lobe with a ground-glass appearance and no contrast enhancement or restricted diffusion. After gross total resection, histopathology showed diffusely infiltrating oligodendroglioma-like cells accompanied by “pennies on a plate” multinucleated cells and nuclear clusters. DNA methylation profiling confirmed the diagnosis of DGONC (calibrated score, 0.99), and chromosomal copy number analysis demonstrated multiple chromosomal gains without monosomy 14. The patient received radiotherapy alone postoperatively and remained clinically stable at the 35.5-month follow-up. This case suggests that the discordance between high-grade histology and an indolent, low-grade radiological appearance is an important clinical feature of DGONC.  Conclusion: This case demonstrates that DGONC can present with non-epileptic onset and without monosomy 14. When a brain tumor exhibits characteristic histology yet a low-grade radiological appearance, DGONC should be considered and the diagnosis confirmed by methylation analysis. Treatment decisions must be made cautiously, based on the extent of surgical resection and histological features.
SN  - 1573-4056
ER  -