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Peer-reviewedCC BY 4.0Nucleic Acids Research

PAZy: an expanded and actively maintained database of experimentally validated plastic-active enzymes

  • Golo Feuerriegel1
  • Bjarne Ackers1
  • Pablo Pérez-García1
  • Jürgen Pleiss2
  • Wolfgang R Streit1
  1. 1Department of Microbiology and Biotechnology, University of Hamburg , D-22609 Hamburg ,
  2. 2Institute of Biochemistry, University of Stuttgart , D-70569 Stuttgart ,
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Abstract

The Plastics-Active Enzyme Database (PAZy) is a manually curated resource for enzymes experimentally shown to act on synthetic or bio-based plastics. It was developed to distinguish experimentally verified plastics-active enzymes from computationally predicted or insufficiently supported candidates. Here, we present an expanded version of PAZy, implemented as a relational database containing >450 plastics-active enzymes with more detailed metadata, broader substrate coverage, and large language model-assisted curation of activity data. The redesigned web interface now enables browsing by protein or plastic substrate, detailed inspections of individual protein entries as well as programmatic access through a public representational state transfer (REST) application programming interface (API). This functionality enables scientists to freely implement PAZy into their own research workflows. By using evidence-based manual curation, PAZy provides a high-confidence resource for both comparative analyses and enzyme discovery in the rapidly growing field of enzymatic plastic degradation. PAZy is freely available at https://www.pazy.eu.

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Cite

BibTeXRIS
BibTeX
@article{feuerriegel2026pazy,
  title = {{PAZy: an expanded and actively maintained database of experimentally validated plastic-active enzymes}},
  author = {Golo Feuerriegel and Bjarne Ackers and Pablo Pérez-García and Jürgen Pleiss and Wolfgang R Streit},
  journal = {Nucleic Acids Research},
  year = {2026},
  month = oct,
  doi = {10.1093/nar/gkag1026},
  url = {https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1026/8937182},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - PAZy: an expanded and actively maintained database of experimentally validated plastic-active enzymes
AU  - Golo Feuerriegel
AU  - Bjarne Ackers
AU  - Pablo Pérez-García
AU  - Jürgen Pleiss
AU  - Wolfgang R Streit
PY  - 2026
DA  - 2026/10/19
JO  - Nucleic Acids Research
DO  - 10.1093/nar/gkag1026
UR  - https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1026/8937182
AB  - The Plastics-Active Enzyme Database (PAZy) is a manually curated resource for enzymes experimentally shown to act on synthetic or bio-based plastics. It was developed to distinguish experimentally verified plastics-active enzymes from computationally predicted or insufficiently supported candidates. Here, we present an expanded version of PAZy, implemented as a relational database containing >450 plastics-active enzymes with more detailed metadata, broader substrate coverage, and large language model-assisted curation of activity data. The redesigned web interface now enables browsing by protein or plastic substrate, detailed inspections of individual protein entries as well as programmatic access through a public representational state transfer (REST) application programming interface (API). This functionality enables scientists to freely implement PAZy into their own research workflows. By using evidence-based manual curation, PAZy provides a high-confidence resource for both comparative analyses and enzyme discovery in the rapidly growing field of enzymatic plastic degradation. PAZy is freely available at https://www.pazy.eu.
SN  - 0305-1048
SN  - 1362-4962
ER  -