Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology.
6 affiliations
- 1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, UP, 201308, India.
- 2Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, UP, 201308, India. [email protected].
- 3Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, UP, 244001, India.
- 4College of Pharmacy, Dubai Medical University, Dubai, United Arab Emirates.
- 5RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.
- 6School of Engineering and IT, Manipal Academy of Higher Education, Dubai Campus, Dubai, United Arab Emirates. [email protected].
Abstract
Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a translational framework linking novasome design with theranostic-guided dosing in cutaneous oncology. A literature search of publications from the time period 2010-2026 was conducted in Scopus, PubMed, and Web of Science to capture studies on formulation, in vitro/ex vivo penetration data, in vivo efficacy, and biodistribution, and the first clinical reports; the priority was given to studies with orthogonal imaging, microdialysis, and/ or IND-relevant endpoints. The literature shows that novasomes allow improved local drug retention, controllable release kinetics, and better follicular and tumor penetration than traditional topical systems. Surface modification and deformable bilayers also help further optimise targeting, and co-loading imaging agents enables real-time visualisation, image-guided dosing, and adaptive PK/PD modelling. Advances in scalable fabrication techniques such as microfluidics and solvent-minimized processes enhance translational feasibility. However, there are still challenges in long-term stability, standardized reporting of critical quality attributes, and regulatory harmonization. In conclusion, novasomes are a pragmatic and modular platform for localized image-guided cutaneous oncology. A unique aspect of this review is the inclusion of novasome formulation strategies, theranostic functions, and concepts of PK/PD-guided dosing in a translational context for cutaneous oncology. The review bridges the gap between formulation development and clinical implementation aspects, thereby offering a practical view for future precision nanomedicine strategies.
Related
- Theranostic Imaging Agents: Integrating Molecular Diagnostics, Precision Therapeutics, and Artificial Intelligence
- Editorial: Translational strategies for chronic lung diseases: emerging therapies and precision medicine
- Multifunctional Hydrogel Technologies in Cardiovascular Regenerative Medicine: From Material Design to Precision Intervention
- Acute respiratory distress syndrome subphenotypes: the translational path from pathobiology to precision medicine
- Advanced drug delivery and PBPK modelling as translational tools for precision therapies in juvenile idiopathic arthritis
BibTeX
@article{azhar2026translational,
title = {{Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology.}},
author = {Md Azhar and Rishabha Malviya and Phool Chandra and Sathvik Belagodu Sridhar and Javedh Shareef and Tarun Wadhwa and Daniel Arockiam},
journal = {Journal of biological engineering},
year = {2026},
month = aug,
doi = {10.1186/s13036-026-00744-8},
url = {https://europepmc.org/article/MED/42972414},
note = {CC BY},
}
RIS
TY - JOUR
TI - Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology.
AU - Md Azhar
AU - Rishabha Malviya
AU - Phool Chandra
AU - Sathvik Belagodu Sridhar
AU - Javedh Shareef
AU - Tarun Wadhwa
AU - Daniel Arockiam
PY - 2026
DA - 2026/08/05
JO - Journal of biological engineering
DO - 10.1186/s13036-026-00744-8
UR - https://europepmc.org/article/MED/42972414
AB - Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a translational framework linking novasome design with theranostic-guided dosing in cutaneous oncology. A literature search of publications from the time period 2010-2026 was conducted in Scopus, PubMed, and Web of Science to capture studies on formulation, in vitro/ex vivo penetration data, in vivo efficacy, and biodistribution, and the first clinical reports; the priority was given to studies with orthogonal imaging, microdialysis, and/ or IND-relevant endpoints. The literature shows that novasomes allow improved local drug retention, controllable release kinetics, and better follicular and tumor penetration than traditional topical systems. Surface modification and deformable bilayers also help further optimise targeting, and co-loading imaging agents enables real-time visualisation, image-guided dosing, and adaptive PK/PD modelling. Advances in scalable fabrication techniques such as microfluidics and solvent-minimized processes enhance translational feasibility. However, there are still challenges in long-term stability, standardized reporting of critical quality attributes, and regulatory harmonization. In conclusion, novasomes are a pragmatic and modular platform for localized image-guided cutaneous oncology. A unique aspect of this review is the inclusion of novasome formulation strategies, theranostic functions, and concepts of PK/PD-guided dosing in a translational context for cutaneous oncology. The review bridges the gap between formulation development and clinical implementation aspects, thereby offering a practical view for future precision nanomedicine strategies.
SN - 1754-1611
ER -