Systemic inflammatory response index: a potential mediator between substance use disorder and sleep disturbance
8 affiliations
- 1Department of Radiology, The Second Xiangya Hospital of Central South University
- 2The Second Xiangya Hospital, Central South University
- 3Experimental Center, Guizhou Center for Disease Control and Prevention
- 4School of Medical Imaging, Changsha Medical University
- 5Department of General Surgery, The Second Xiangya Hospital of Central South University
- 6Clinical Research Center for Breast Disease in Hunan Province
- 7Clinical Research Center for Medical Imaging in Hunan Province
- 8Department of Radiology Quality Control Center in Hunan Province
Abstract
Study objectives: Substance use disorder (SUD) and sleep disturbance share a complex, bidirectional relationship. However, the role of the systemic inflammation response index (SIRI) in this relationship remains to be explored, which will be beneficial for detecting SUD-related sleep disturbances.
Methods: Utilizing diverse samples from the National Health and Nutrition Examination Survey (NHANES) (n = 2,533) as well as self-collected clinical data (n = 88), we explored the associations among SUD, SIRI, and sleep disturbance. In NHANES dataset, weighted logistic regression and multiple machine learning (ML) models were employed to assess the relationship between SIRI and sleep disturbance, as well as SIRI importance in SUD group. Mediation analysis examined the role of SIRI in mediating the SUD-sleep disturbance association. During clinical confirmation, a two-sample t-test was used to discover differences in SIRI between opioid use disorder (OUD) and healthy controls (HC). Correlation of SIRI and Pittsburgh Sleep Quality Index (PSQI) was performed by partial correlation within OUD group.
Results: The analyses on NHANES datasets uncovered significant “SUD–SIRI–sleep disturbance” relationships, and SIRI ranked first in diagnosing sleep status of SUD subjects. Through validation via clinical datasets, OUD individuals also had higher SIRI levels and sleep disturbance risk than HC.
Conclusion: Our findings suggest that SIRI statistically mediates the relationship between SUD and sleep disturbance in a cross-sectional context, positioning it as a potential adjunctive monitoring indicator for SUD-related psychiatric management. These results offer preliminary correlational evidence for mitigating sleep disruption through anti-inflammatory approaches, warranting further longitudinal and experimental validation.
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BibTeX
@article{yang2026systemic,
title = {{Systemic inflammatory response index: a potential mediator between substance use disorder and sleep disturbance}},
author = {Longtao Yang and Yihui Tang and Xuemei Wang and Xiang Chen and Qinyu Zou and Yule Zeng and Qitong Chen and Jun Liu},
journal = {Frontiers in Pharmacology},
year = {2026},
month = oct,
doi = {10.3389/fphar.2026.1964417},
url = {https://www.frontiersin.org/articles/10.3389/fphar.2026.1964417/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Systemic inflammatory response index: a potential mediator between substance use disorder and sleep disturbance
AU - Longtao Yang
AU - Yihui Tang
AU - Xuemei Wang
AU - Xiang Chen
AU - Qinyu Zou
AU - Yule Zeng
AU - Qitong Chen
AU - Jun Liu
PY - 2026
DA - 2026/10/20
JO - Frontiers in Pharmacology
DO - 10.3389/fphar.2026.1964417
UR - https://www.frontiersin.org/articles/10.3389/fphar.2026.1964417/full
AB - Study objectives: Substance use disorder (SUD) and sleep disturbance share a complex, bidirectional relationship. However, the role of the systemic inflammation response index (SIRI) in this relationship remains to be explored, which will be beneficial for detecting SUD-related sleep disturbances. Methods: Utilizing diverse samples from the National Health and Nutrition Examination Survey (NHANES) (n = 2,533) as well as self-collected clinical data (n = 88), we explored the associations among SUD, SIRI, and sleep disturbance. In NHANES dataset, weighted logistic regression and multiple machine learning (ML) models were employed to assess the relationship between SIRI and sleep disturbance, as well as SIRI importance in SUD group. Mediation analysis examined the role of SIRI in mediating the SUD-sleep disturbance association. During clinical confirmation, a two-sample t-test was used to discover differences in SIRI between opioid use disorder (OUD) and healthy controls (HC). Correlation of SIRI and Pittsburgh Sleep Quality Index (PSQI) was performed by partial correlation within OUD group. Results: The analyses on NHANES datasets uncovered significant “SUD–SIRI–sleep disturbance” relationships, and SIRI ranked first in diagnosing sleep status of SUD subjects. Through validation via clinical datasets, OUD individuals also had higher SIRI levels and sleep disturbance risk than HC. Conclusion: Our findings suggest that SIRI statistically mediates the relationship between SUD and sleep disturbance in a cross-sectional context, positioning it as a potential adjunctive monitoring indicator for SUD-related psychiatric management. These results offer preliminary correlational evidence for mitigating sleep disruption through anti-inflammatory approaches, warranting further longitudinal and experimental validation.
SN - 1663-9812
ER -