Skip to content
DraconiticResearch
Search Sources API
194,216 studies31 sourcesUpdated 49 min ago
Peer-reviewedCC BYJournal of neuroinflammation

Divergent Schwann cell-immune cell trajectories across vestibular schwannoma subtypes mirror nerve injury-repair programs.

  • Han-Guang Zhao1,2
  • Xiao-Ping Wang3,4
  • Jing Zhang5,6
  • Si-Kang Ren1,7
  • Yu-Chao Liang7
  • Hui Li1
  • Jiang-Ming Li1
  • Xiao-Bin Zhao8
  • Lei-Ming Wang9
  • Yuan-Xiang Lin10
  • Zhi Li11,12
  • Fu Zhao13,14
14 affiliations
  1. 1Department of Pediatric Neurosurgery, Beijing Key Laboratory of Drug Innovation for Neuro-Oncology, Beijing Neurosurgical Institute, Capital Medical University, 119 South 4th Ring West Road, Fengtai District, Beijing, 100070, PR China.
  2. 2Department of Neuro-Oncology, Sanbo Brain Hospital, Capital Medical University, Beijing, PR China.
  3. 3Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian province, 350005, PR China.
  4. 4Department of Neurosurgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province, 361000, China.
  5. 5Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, 102600, P.R. China.
  6. 6Department of Research and Development, Santo Therapeutic co., Xiaoshan District, Hang Zhou, PR China.
  7. 7Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
  8. 8Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
  9. 9Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
  10. 10Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian province, 350005, PR China. [email protected].
  11. 11Department of Pediatric Neurosurgery, Beijing Key Laboratory of Drug Innovation for Neuro-Oncology, Beijing Neurosurgical Institute, Capital Medical University, 119 South 4th Ring West Road, Fengtai District, Beijing, 100070, PR China. [email protected].
  12. 12Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China. [email protected].
  13. 13Department of Pediatric Neurosurgery, Beijing Key Laboratory of Drug Innovation for Neuro-Oncology, Beijing Neurosurgical Institute, Capital Medical University, 119 South 4th Ring West Road, Fengtai District, Beijing, 100070, PR China. [email protected].
  14. 14Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, 102600, P.R. China. [email protected].
Read full textPDFDOICite

Abstract

Although Schwann cells (SCs) are increasingly recognised as active contributors to cancer progression, their cell-autonomous oncogenic mechanisms underlying vestibular schwannoma (VS) development remain poorly defined. Moreover, the roles of heterogeneity within the tumour microenvironment (TME) in VS pathogenesis remain unclear. In this study, we performed integrative multi-omic analyses of sporadic VSs and NF2-related schwannomatosis (NF2-SWN) VSs, using bulk RNA-sequencing, single-nucleus RNA-sequencing (snRNA-seq), DNA methylation profiling, and immunohistochemistry (IHC). Transcriptomic and DNA methylation profiling analyses identified two distinct molecular subgroups, immune-enriched schwannoma (IES) and immune-depleted schwannoma (IDS), independent of syndromic status. We developed multigene and IHC-based classifiers that robustly distinguish the two molecular subgroups. Notably, we found significant differences in clinical characteristics and prognostic outcomes across VS subgroups. Furthermore, snRNA-seq revealed cellular heterogeneity within the VS microenvironment, with phenotypic transitions in SCs and immune cells that closely recapitulated the sequential stages of nerve injury and repair. Collectively, our study reveals that SC plasticity and immune cell dynamics within the tumor microenvironment contribute to intertumoral heterogeneity in vestibular schwannomas, offering insights into the biological processes underlying tumor progression and nerve injury-repair programs.

Related

  1. Neuroanatomical Subtypes of Schizophrenia Reveal Divergent Atrophy Trajectories and Distinct Associations with Long-Term Clozapine Use
    Xiao Chang, Yuchao Jiang, Bochao Danae Lin +14
    Schizophrenia BulletinPeer-reviewedPublisher termsFull textPsychiatry & mental healthPMC
  2. Spontaneous resolution of vestibular schwannoma: A singular phenomenon.
    Rasha Hassan Noreldeen, Miguel Ángel Arráez Sánchez, Ossama Al-Mefty
    Surgical neurology internationalPeer-reviewedCC BY-NC-SAFull textEpidemiology & public healthEurope PMCPMC
  3. Bilateral Vision Loss due to Fulminant Hypertensive Optic Neuropathy Mimicking Cortical Blindness in a Patient with Co-existing Vestibular Schwannoma: A Case Report
    Naina Chaturvedi, Rohan Jagadish, Kritika Aggarwal +2
    Journal of Clinical and Diagnostic ResearchPeer-reviewedCC BY-NC-NDFull textPsychiatry & mental healthDOAJ
  4. Development of a multi-parameter MRI-based habitat radiomics model for differential diagnosis of vestibular schwannoma and meningioma in the cerebellopontine angle: a multi-center study.
    Xiyuan Tang, Xueyun Deng, Yanfen Zhao +4
    BMC cancerPeer-reviewedCC BY-NC-NDFull textMedical imaging & radiologyEurope PMC
  5. Intraoperative detection of a false-negative facial motor evoked potential by direct facial nerve stimulation during vestibular schwannoma surgery: A case report.
    Masahiro Nonaka, Takeshi Itakura, Katsuya Ueno +6
    Surgical neurology internationalPeer-reviewedCC BY-NC-SAFull textSurgery & anaesthesiaEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{zhao2026divergent,
  title = {{Divergent Schwann cell-immune cell trajectories across vestibular schwannoma subtypes mirror nerve injury-repair programs.}},
  author = {Han-Guang Zhao and Xiao-Ping Wang and Jing Zhang and Si-Kang Ren and Yu-Chao Liang and Hui Li and Jiang-Ming Li and Xiao-Bin Zhao and Lei-Ming Wang and Yuan-Xiang Lin and Zhi Li and Fu Zhao},
  journal = {Journal of neuroinflammation},
  year = {2026},
  month = aug,
  doi = {10.1186/s12974-026-03995-w},
  url = {https://europepmc.org/article/MED/42958385},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Divergent Schwann cell-immune cell trajectories across vestibular schwannoma subtypes mirror nerve injury-repair programs.
AU  - Han-Guang Zhao
AU  - Xiao-Ping Wang
AU  - Jing Zhang
AU  - Si-Kang Ren
AU  - Yu-Chao Liang
AU  - Hui Li
AU  - Jiang-Ming Li
AU  - Xiao-Bin Zhao
AU  - Lei-Ming Wang
AU  - Yuan-Xiang Lin
AU  - Zhi Li
AU  - Fu Zhao
PY  - 2026
DA  - 2026/08/03
JO  - Journal of neuroinflammation
DO  - 10.1186/s12974-026-03995-w
UR  - https://europepmc.org/article/MED/42958385
AB  - Although Schwann cells (SCs) are increasingly recognised as active contributors to cancer progression, their cell-autonomous oncogenic mechanisms underlying vestibular schwannoma (VS) development remain poorly defined. Moreover, the roles of heterogeneity within the tumour microenvironment (TME) in VS pathogenesis remain unclear. In this study, we performed integrative multi-omic analyses of sporadic VSs and NF2-related schwannomatosis (NF2-SWN) VSs, using bulk RNA-sequencing, single-nucleus RNA-sequencing (snRNA-seq), DNA methylation profiling, and immunohistochemistry (IHC). Transcriptomic and DNA methylation profiling analyses identified two distinct molecular subgroups, immune-enriched schwannoma (IES) and immune-depleted schwannoma (IDS), independent of syndromic status. We developed multigene and IHC-based classifiers that robustly distinguish the two molecular subgroups. Notably, we found significant differences in clinical characteristics and prognostic outcomes across VS subgroups. Furthermore, snRNA-seq revealed cellular heterogeneity within the VS microenvironment, with phenotypic transitions in SCs and immune cells that closely recapitulated the sequential stages of nerve injury and repair. Collectively, our study reveals that SC plasticity and immune cell dynamics within the tumor microenvironment contribute to intertumoral heterogeneity in vestibular schwannomas, offering insights into the biological processes underlying tumor progression and nerve injury-repair programs.
SN  - 1742-2094
ER  -