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Peer-reviewedLicence not statedNature

An open structure-guided RNA foundation model for generalizable prediction

  • Heqin Zhu1,2,3,4
  • Ruifeng Li5,6
  • Feng Zhang1,2,3,4
  • Haobin Chen1,2,3,4
  • Feng Zhang1,2,3,4
  • Fenghe Tang1,2,3,4
  • Tong Ye1,2,3,4
  • Xin Li1,2,3,4
  • Yunjie Gu1,2,3,7,4,8
  • Peng Xiong9,10,11
  • S. Kevin Zhou12,13,14,15,16
16 affiliations
  1. 1Medical Imaging, Robotics, Analytic Computing and Learning (MIRACLE) Lab, YRD-RIGHT, Suzhou Institute for Advanced Research, USTC, Suzhou, China
  2. 2School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China
  3. 3Center for Medical Imaging, Robotics, Analytic Computing & Learning (MIRACLE), Suzhou Institute for Advance Research, USTC, Suzhou, Jiangsu, 1513, China
  4. 4School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui, 230026, China
  5. 5College of Computer Science and Technology, Zhejiang University, Hangzhou, China
  6. 6College of Computer Science and Technology, Zhejiang University, Hangzhou, Zhejiang, 10027, China
  7. 7Jiangsu Provincial Key Laboratory of Multimodal Digital Twin Technology, Suzhou, Jiangsu, 215123, China
  8. 8State Key Laboratory of Precision and Intelligent Chemistry, USTC, Hefei, Anhui, 230026, China
  9. 9Biomedical Basic Research Center (BBRC) of Jiangsu, Suzhou, China. [email protected]
  10. 10Medical Imaging, Robotics, Analytic Computing and Learning (MIRACLE) Lab, YRD-RIGHT, Suzhou Institute for Advanced Research, USTC, Suzhou, China. [email protected]
  11. 11School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China. [email protected]
  12. 12Biomedical Basic Research Center (BBRC) of Jiangsu, Suzhou, China. [email protected]
  13. 13Jiangsu Key Laboratory of Multimodal Digital Twin Technology, Suzhou, China. [email protected]
  14. 14Medical Imaging, Robotics, Analytic Computing and Learning (MIRACLE) Lab, YRD-RIGHT, Suzhou Institute for Advanced Research, USTC, Suzhou, China. [email protected]
  15. 15School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China. [email protected]
  16. 16State Key Laboratory of Precision and Intelligent Chemistry, Hefei, China. [email protected]
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{zhu2026open,
  title = {{An open structure-guided RNA foundation model for generalizable prediction}},
  author = {Heqin Zhu and Ruifeng Li and Feng Zhang and Haobin Chen and Feng Zhang and Fenghe Tang and Tong Ye and Xin Li and Yunjie Gu and Peng Xiong and S. Kevin Zhou},
  journal = {Nature},
  year = {2026},
  month = nov,
  doi = {10.1038/s41586-026-11210-2},
  url = {https://doi.org/10.1101/2025.08.06.668731},
}
RIS
TY  - JOUR
TI  - An open structure-guided RNA foundation model for generalizable prediction
AU  - Heqin Zhu
AU  - Ruifeng Li
AU  - Feng Zhang
AU  - Haobin Chen
AU  - Feng Zhang
AU  - Fenghe Tang
AU  - Tong Ye
AU  - Xin Li
AU  - Yunjie Gu
AU  - Peng Xiong
AU  - S. Kevin Zhou
PY  - 2026
DA  - 2026/11/04
JO  - Nature
DO  - 10.1038/s41586-026-11210-2
UR  - https://doi.org/10.1101/2025.08.06.668731
SN  - 0028-0836
SN  - 1476-4687
ER  -