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Peer-reviewedLicence not statedNature Methods

A generalizable Hi-C foundation model for chromatin architecture, single-cell and multiomics analysis across species

  • Xiao Wang1,2,3
  • Yuanyuan Zhang4,5
  • Suhita Ray6,7,3
  • Anupama Jha1,3
  • Tangqi Fang2,3
  • Shengqi Hang2,3
  • Sergei R. Doulatov8,9,3
  • William Stafford Noble10,11,3
  • Sheng Wang12,3
12 affiliations
  1. 1Department of Genome Sciences, University of Washington, Seattle, WA, USA
  2. 2Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA
  3. 3University of Washington
  4. 4Department of Computer Science, Purdue University, West Lafayette, IN, USA
  5. 5Purdue University
  6. 6Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA
  7. 7Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA
  8. 8Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. [email protected]
  9. 9Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. [email protected]
  10. 10Department of Genome Sciences, University of Washington, Seattle, WA, USA. [email protected]
  11. 11Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. [email protected]
  12. 12Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. [email protected]
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{wang2026generalizable,
  title = {{A generalizable Hi-C foundation model for chromatin architecture, single-cell and multiomics analysis across species}},
  author = {Xiao Wang and Yuanyuan Zhang and Suhita Ray and Anupama Jha and Tangqi Fang and Shengqi Hang and Sergei R. Doulatov and William Stafford Noble and Sheng Wang},
  journal = {Nature Methods},
  year = {2026},
  month = jun,
  doi = {10.1038/s41592-026-03097-8},
  url = {https://doi.org/10.1101/2024.12.16.628821},
}
RIS
TY  - JOUR
TI  - A generalizable Hi-C foundation model for chromatin architecture, single-cell and multiomics analysis across species
AU  - Xiao Wang
AU  - Yuanyuan Zhang
AU  - Suhita Ray
AU  - Anupama Jha
AU  - Tangqi Fang
AU  - Shengqi Hang
AU  - Sergei R. Doulatov
AU  - William Stafford Noble
AU  - Sheng Wang
PY  - 2026
DA  - 2026/06/15
JO  - Nature Methods
DO  - 10.1038/s41592-026-03097-8
UR  - https://doi.org/10.1101/2024.12.16.628821
SN  - 1548-7091
SN  - 1548-7105
ER  -