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Peer-reviewedCC BY 4.0Japanese Journal of Radiology

Imaging of benign salivary gland tumors: an update based on the fifth WHO classification, with a focus on rare histologic types and newly listed entities—part I

  • Tohru Takeshita1
  • Taro Shimono2
  • Hirotaka Takita2
  • Daiju Ueda2,3
  • Kayo Ueda1
  • Yukio Miki2
  • Akira Yamamoto2
  1. 1Department of Radiology, Osaka Habikino Medical Center, 3-7-1, Habikino, Habikino City, Osaka 583-8588 Japan
  2. 2Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3, Asahi-Machi, Abeno-ku, Osaka 545-8585 Japan
  3. 3Department of Artificial Intelligence, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan
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Abstract

The salivary glands give rise to a diverse range of histologic tumor types. The World Health Organization (WHO) Classification of Head and Neck Tumors has been revised from the fourth edition (2017) to the fifth edition; the online version was released in March 2022, followed by the publication of the WHO Blue Book in March 2024. In the current classification of salivary gland tumors (SGTs), 15 benign and 21 malignant epithelial tumor types are categorized. Furthermore, four new benign entities were added: intercalated duct adenoma/hyperplasia, striated duct adenoma, sclerosing polycystic adenoma, and keratocystoma. Imaging features of prevalent benign tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, salivary gland myoepithelioma, and oncocytoma, are thoroughly documented in the radiologic literature. Conversely, infrequently encountered and newly categorized benign tumors often remain unrecognized by many radiologists. In this Part I of a two-part series, we evaluate infrequently encountered benign SGTs within the current WHO classification, including cystadenoma of the salivary glands, canalicular adenoma, sialadenoma papilliferum, ductal papillomas, sebaceous adenoma, and lymphadenoma. The discussion focuses on diagnostic criteria with an emphasis on radiologic–pathologic correlations.

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Cite

BibTeXRIS
BibTeX
@article{takeshita2026imaging,
  title = {{Imaging of benign salivary gland tumors: an update based on the fifth WHO classification, with a focus on rare histologic types and newly listed entities—part I}},
  author = {Tohru Takeshita and Taro Shimono and Hirotaka Takita and Daiju Ueda and Kayo Ueda and Yukio Miki and Akira Yamamoto},
  journal = {Japanese Journal of Radiology},
  year = {2026},
  month = aug,
  doi = {10.1007/s11604-026-02063-w},
  url = {https://doi.org/10.1007/s11604-026-02063-w},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Imaging of benign salivary gland tumors: an update based on the fifth WHO classification, with a focus on rare histologic types and newly listed entities—part I
AU  - Tohru Takeshita
AU  - Taro Shimono
AU  - Hirotaka Takita
AU  - Daiju Ueda
AU  - Kayo Ueda
AU  - Yukio Miki
AU  - Akira Yamamoto
PY  - 2026
DA  - 2026/08/14
JO  - Japanese Journal of Radiology
DO  - 10.1007/s11604-026-02063-w
UR  - https://doi.org/10.1007/s11604-026-02063-w
AB  - The salivary glands give rise to a diverse range of histologic tumor types. The World Health Organization (WHO) Classification of Head and Neck Tumors has been revised from the fourth edition (2017) to the fifth edition; the online version was released in March 2022, followed by the publication of the WHO Blue Book in March 2024. In the current classification of salivary gland tumors (SGTs), 15 benign and 21 malignant epithelial tumor types are categorized. Furthermore, four new benign entities were added: intercalated duct adenoma/hyperplasia, striated duct adenoma, sclerosing polycystic adenoma, and keratocystoma. Imaging features of prevalent benign tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, salivary gland myoepithelioma, and oncocytoma, are thoroughly documented in the radiologic literature. Conversely, infrequently encountered and newly categorized benign tumors often remain unrecognized by many radiologists. In this Part I of a two-part series, we evaluate infrequently encountered benign SGTs within the current WHO classification, including cystadenoma of the salivary glands, canalicular adenoma, sialadenoma papilliferum, ductal papillomas, sebaceous adenoma, and lymphadenoma. The discussion focuses on diagnostic criteria with an emphasis on radiologic–pathologic correlations.
SN  - 1867-1071
SN  - 1867-108X
ER  -