Severe Cardiomyopathy Following Takotsubo Syndrome in a Patient Suffering from Eosinophilic Granulomatosis With Polyangiitis: A Case Report
Abstract
Cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA) strongly influences the prognosis. Takotsubo syndrome (TTS) is a reversible stress-induced cardiomyopathy that has rarely been reported in patients with EGPA. A 39-year-old woman was diagnosed with EGPA based on marked eosinophilia, systemic manifestations, and the histopathological eosinophilic infiltration of multiple organs. After remission with corticosteroids, immunosuppressants, and intravenous immunoglobulin, she suddenly developed chest pain with an ST elevation and severe left ventricular dysfunction, but normal coronary angiography findings. TTS was diagnosed. Her cardiac function recovered. However, an endomyocardial biopsy revealed advanced myocardial injury without eosinophilic infiltration. Therapy (corticosteroids, immunosuppressants, intravenous immunoglobulin, and mepolizumab) achieved long-term survival despite severe cardiac involvement.
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BibTeX
@article{yamashita2026severe,
title = {{Severe Cardiomyopathy Following Takotsubo Syndrome in a Patient Suffering from Eosinophilic Granulomatosis With Polyangiitis: A Case Report}},
author = {Yuga Yamashita and Chiyako Oshikata and Nami Masumoto and Sachiko Takaoka and Takuya Nakashima and Kaho Matsunaga and Yuka Kodama and Kosuke Terada and Hinako Masumitsu and Atsushi Miyasaka and Tatsuya Muraoka and Takeshi Kaneko and Naomi Tsurikisawa},
journal = {Internal Medicine},
year = {2026},
month = jul,
doi = {10.2169/internalmedicine.7487-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7487-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Severe Cardiomyopathy Following Takotsubo Syndrome in a Patient Suffering from Eosinophilic Granulomatosis With Polyangiitis: A Case Report
AU - Yuga Yamashita
AU - Chiyako Oshikata
AU - Nami Masumoto
AU - Sachiko Takaoka
AU - Takuya Nakashima
AU - Kaho Matsunaga
AU - Yuka Kodama
AU - Kosuke Terada
AU - Hinako Masumitsu
AU - Atsushi Miyasaka
AU - Tatsuya Muraoka
AU - Takeshi Kaneko
AU - Naomi Tsurikisawa
PY - 2026
DA - 2026/07/04
JO - Internal Medicine
DO - 10.2169/internalmedicine.7487-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7487-26/_article
AB - Cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA) strongly influences the prognosis. Takotsubo syndrome (TTS) is a reversible stress-induced cardiomyopathy that has rarely been reported in patients with EGPA. A 39-year-old woman was diagnosed with EGPA based on marked eosinophilia, systemic manifestations, and the histopathological eosinophilic infiltration of multiple organs. After remission with corticosteroids, immunosuppressants, and intravenous immunoglobulin, she suddenly developed chest pain with an ST elevation and severe left ventricular dysfunction, but normal coronary angiography findings. TTS was diagnosed. Her cardiac function recovered. However, an endomyocardial biopsy revealed advanced myocardial injury without eosinophilic infiltration. Therapy (corticosteroids, immunosuppressants, intravenous immunoglobulin, and mepolizumab) achieved long-term survival despite severe cardiac involvement.
SN - 1349-7235
SN - 0918-2918
ER -