Eosinophilic Granulomatosis with Polyangiitis Complicated by Eosinophilic Chronic Rhinosinusitis Successfully Treated with Combination of Mepolizumab and Dupilumab
Abstract
A 50-year-old man with a history of bronchial asthma was admitted to our hospital with peripheral neuropathy, sinusitis, and eosinophilia. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). The symptoms partially improved with a combination of prednisolone and mepolizumab. However, nasal mucosal biopsy revealed a complication due to eosinophilic sinusitis. The addition of dupilumab resulted in the improvement of sinusitis. Few reports exist on the combination of these two drugs for EGPA, and no case reports exist on the addition of dupilumab in patients with residual eosinophilic sinusitis after treatment with prednisolone and mepolizumab. This case is valuable for future consideration in cases involving combination therapy.
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BibTeX
@article{inomata2026eosinophilic,
title = {{Eosinophilic Granulomatosis with Polyangiitis Complicated by Eosinophilic Chronic Rhinosinusitis Successfully Treated with Combination of Mepolizumab and Dupilumab}},
author = {Hirotake Inomata and Noboru Kitamura and Shinya Asatani and Masashi Uchikawa and Kiichi Sugito and Masahiro Nishihara and Kumiko Akiya and Miho Oshima and Hideki Nakamura},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.6638-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_6638-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Eosinophilic Granulomatosis with Polyangiitis Complicated by Eosinophilic Chronic Rhinosinusitis Successfully Treated with Combination of Mepolizumab and Dupilumab
AU - Hirotake Inomata
AU - Noboru Kitamura
AU - Shinya Asatani
AU - Masashi Uchikawa
AU - Kiichi Sugito
AU - Masahiro Nishihara
AU - Kumiko Akiya
AU - Miho Oshima
AU - Hideki Nakamura
PY - 2026
DA - 2026/08/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.6638-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_6638-25/_article
AB - A 50-year-old man with a history of bronchial asthma was admitted to our hospital with peripheral neuropathy, sinusitis, and eosinophilia. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). The symptoms partially improved with a combination of prednisolone and mepolizumab. However, nasal mucosal biopsy revealed a complication due to eosinophilic sinusitis. The addition of dupilumab resulted in the improvement of sinusitis. Few reports exist on the combination of these two drugs for EGPA, and no case reports exist on the addition of dupilumab in patients with residual eosinophilic sinusitis after treatment with prednisolone and mepolizumab. This case is valuable for future consideration in cases involving combination therapy.
SN - 1349-7235
SN - 0918-2918
ER -