Evaluation of the Perimouse Online Suprathreshold Visual Field Test for Glaucoma Screening in a Chinese Population: A Comparison with the Humphrey Field Analyzer.
- 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China.
- 2Department of Psychology, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Abstract
To evaluate the diagnostic performance and spatial agreement of an online suprathreshold perimeter (Perimouse) compared with the Humphrey Field Analyzer (HFA) for detecting glaucomatous visual field defects. In this prospective comparative study, 174 participants (283 eyes with open-angle glaucoma or healthy controls) underwent Perimouse suprathreshold program and HFA. Abnormal points (missed stimuli in Perimouse; points with P<0.5% on HFA total deviation map) were compared. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis. Point-wise performance used neural network-derived area under the curve (AUC) and Cohen's κ. Perimouse abnormal-point counts were correlated with HFA abnormal-point counts (r = 0.88, P < 0.001) and negatively correlated with HFA mean deviation (r = -0.80, P < 0.001). The intraclass correlation coefficient for abnormal-point counts between Perimouse and HFA was 0.93, and Bland-Altman analysis showed a mean bias of 0.73 abnormal points, with 95% limits of agreement ranging from -10.70 to 12.17. A cutoff of five abnormal points achieved 85.9% sensitivity and 97.9% specificity (AUC = 0.97), with performance improving with disease severity. Point-wise κ values ranged from 0.32 to 0.78 (AUC, 0.67-0.96). The test duration for Perimouse was 2.64 ± 1.83 minutes. Perimouse demonstrated reasonable overall diagnostic accuracy for detecting HFA-defined visual field defects. Diagnostic performance was higher for moderate and advanced glaucomatous defects than for early defects, with variable point-wise agreement with HFA. Perimouse may serve as a rapid, adjunctive tool for preliminary functional screening of glaucomatous visual field loss.
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BibTeX
@article{shen2026evaluation,
title = {{Evaluation of the Perimouse Online Suprathreshold Visual Field Test for Glaucoma Screening in a Chinese Population: A Comparison with the Humphrey Field Analyzer.}},
author = {Xiaoyuan Shen and Zidong Chen and Kaixin Tan and Yanmei Fan and Pingping Liu and Haorui Wang and Jing Samantha Pan and Yangfan Yang and Minbin Yu},
journal = {Clinical ophthalmology (Auckland, N.Z.)},
year = {2026},
month = oct,
doi = {10.2147/opth.s649252},
url = {https://europepmc.org/article/MED/42953797},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Evaluation of the Perimouse Online Suprathreshold Visual Field Test for Glaucoma Screening in a Chinese Population: A Comparison with the Humphrey Field Analyzer.
AU - Xiaoyuan Shen
AU - Zidong Chen
AU - Kaixin Tan
AU - Yanmei Fan
AU - Pingping Liu
AU - Haorui Wang
AU - Jing Samantha Pan
AU - Yangfan Yang
AU - Minbin Yu
PY - 2026
DA - 2026/10/24
JO - Clinical ophthalmology (Auckland, N.Z.)
DO - 10.2147/opth.s649252
UR - https://europepmc.org/article/MED/42953797
AB - To evaluate the diagnostic performance and spatial agreement of an online suprathreshold perimeter (Perimouse) compared with the Humphrey Field Analyzer (HFA) for detecting glaucomatous visual field defects. In this prospective comparative study, 174 participants (283 eyes with open-angle glaucoma or healthy controls) underwent Perimouse suprathreshold program and HFA. Abnormal points (missed stimuli in Perimouse; points with P<0.5% on HFA total deviation map) were compared. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis. Point-wise performance used neural network-derived area under the curve (AUC) and Cohen's κ. Perimouse abnormal-point counts were correlated with HFA abnormal-point counts (r = 0.88, P < 0.001) and negatively correlated with HFA mean deviation (r = -0.80, P < 0.001). The intraclass correlation coefficient for abnormal-point counts between Perimouse and HFA was 0.93, and Bland-Altman analysis showed a mean bias of 0.73 abnormal points, with 95% limits of agreement ranging from -10.70 to 12.17. A cutoff of five abnormal points achieved 85.9% sensitivity and 97.9% specificity (AUC = 0.97), with performance improving with disease severity. Point-wise κ values ranged from 0.32 to 0.78 (AUC, 0.67-0.96). The test duration for Perimouse was 2.64 ± 1.83 minutes. Perimouse demonstrated reasonable overall diagnostic accuracy for detecting HFA-defined visual field defects. Diagnostic performance was higher for moderate and advanced glaucomatous defects than for early defects, with variable point-wise agreement with HFA. Perimouse may serve as a rapid, adjunctive tool for preliminary functional screening of glaucomatous visual field loss.
SN - 1177-5467
SN - 1177-5483
ER -