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Peer-reviewedCC BYCell biochemistry and function

Jing Si Herbal Tea Aqueous Extract Modulates G-CSF-Induced Hematopoietic Stem and Progenitor Cells Mobilization and Mitigates Associated Pain in a Murine Model.

  • Ji-Yan Lyu1,2
  • Bruce Chi-Kang Tsai3
  • Chih-Ying Chi4,5
  • Yu-Ling Wu3,5
  • Wen-Tsan Weng6
  • Kai-Hung Wang6
  • Kuo-Liang Yang7
  • Chih-Yang Huang3,4,5,8,9,10,11
  • Shinn-Zong Lin1,12,13,14
14 affiliations
  1. 1Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
  2. 2Department of Nursing, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  3. 3Department of Precision Chinese Herbal Medicine and Molecular Medicine Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
  4. 4Department of Precision Chinese Herbal Medicine and Molecular Medicine Research, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan.
  5. 5School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
  6. 6Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  7. 7Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  8. 8Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  9. 9Office of Research & Development, Asia University, Taichung, Taiwan.
  10. 10Superintendent's Office, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  11. 11Department of Nutritional Science, Fu Jen Catholic University, New Taipei City, Taiwan.
  12. 12Bioinnovation Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  13. 13Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  14. 14Buddhist Tzu Chi Foundation Hospital, Hualien, Taiwan.
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Abstract

Granulocyte colony-stimulating factor (G-CSF) is widely used for stem cell mobilization but is associated with side effects such as pain, which often discourages healthy donors. Jing Si Herbal Tea (JSHT), a novel Chinese herbal formula comprising eight different Chinese herbal medicines, has been shown to exert pleiotropic effects against several disorders. The present study primarily explored the potential effects of JSHT aqueous extract on G-CSF-induced stem cell mobilization and the alleviation of G-CSF-induced pain. The effects of JSHT on G-CSF-induced hematopoietic stem and progenitor cell (HSPC) mobilization and pain-related responses in mice were comprehensively evaluated using flow cytometric analysis, nociceptive behavioral assessments, and immunofluorescence staining. Animal studies demonstrated that JSHT had no significant effect on white blood cell (WBC) levels or HSPC mobilization. However, it helped replenish the HSPC level in the bone marrow following G-CSF-induced mobilization of these cells into the peripheral circulation. Furthermore, JSHT increased IFNγ expression in CD45⁺ and CD45⁺CD34⁺ cells, suggesting its potential to enhance HSPC activity. JSHT also alleviated thermal hyperalgesia, with effects comparable to those of acetaminophen (APAP), by reducing neuroinflammation and modulating the expression of cannabinoid receptor 1 (CB1) and the sodium channel Nav1.8 in the dorsal root ganglia (DRG), thereby reducing G-CSF-induced pain. JSHT had no effect on HSPC mobilization into the peripheral blood but might help regulate HSPC level within the bone marrow and potentially enhance HSPC function during G-CSF treatment. Additionally, JSHT effectively attenuated G-CSF-induced pain, suggesting its potential as a supportive therapy during G-CSF-induced stem cell mobilization.

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Cite

BibTeXRIS
BibTeX
@article{lyu2026jing,
  title = {{Jing Si Herbal Tea Aqueous Extract Modulates G-CSF-Induced Hematopoietic Stem and Progenitor Cells Mobilization and Mitigates Associated Pain in a Murine Model.}},
  author = {Ji-Yan Lyu and Bruce Chi-Kang Tsai and Chih-Ying Chi and Yu-Ling Wu and Wen-Tsan Weng and Kai-Hung Wang and Kuo-Liang Yang and Chih-Yang Huang and Shinn-Zong Lin},
  journal = {Cell biochemistry and function},
  year = {2026},
  month = nov,
  doi = {10.1002/cbf.70335},
  url = {https://europepmc.org/article/MED/42968659},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Jing Si Herbal Tea Aqueous Extract Modulates G-CSF-Induced Hematopoietic Stem and Progenitor Cells Mobilization and Mitigates Associated Pain in a Murine Model.
AU  - Ji-Yan Lyu
AU  - Bruce Chi-Kang Tsai
AU  - Chih-Ying Chi
AU  - Yu-Ling Wu
AU  - Wen-Tsan Weng
AU  - Kai-Hung Wang
AU  - Kuo-Liang Yang
AU  - Chih-Yang Huang
AU  - Shinn-Zong Lin
PY  - 2026
DA  - 2026/11/01
JO  - Cell biochemistry and function
DO  - 10.1002/cbf.70335
UR  - https://europepmc.org/article/MED/42968659
AB  - Granulocyte colony-stimulating factor (G-CSF) is widely used for stem cell mobilization but is associated with side effects such as pain, which often discourages healthy donors. Jing Si Herbal Tea (JSHT), a novel Chinese herbal formula comprising eight different Chinese herbal medicines, has been shown to exert pleiotropic effects against several disorders. The present study primarily explored the potential effects of JSHT aqueous extract on G-CSF-induced stem cell mobilization and the alleviation of G-CSF-induced pain. The effects of JSHT on G-CSF-induced hematopoietic stem and progenitor cell (HSPC) mobilization and pain-related responses in mice were comprehensively evaluated using flow cytometric analysis, nociceptive behavioral assessments, and immunofluorescence staining. Animal studies demonstrated that JSHT had no significant effect on white blood cell (WBC) levels or HSPC mobilization. However, it helped replenish the HSPC level in the bone marrow following G-CSF-induced mobilization of these cells into the peripheral circulation. Furthermore, JSHT increased IFNγ expression in CD45⁺ and CD45⁺CD34⁺ cells, suggesting its potential to enhance HSPC activity. JSHT also alleviated thermal hyperalgesia, with effects comparable to those of acetaminophen (APAP), by reducing neuroinflammation and modulating the expression of cannabinoid receptor 1 (CB1) and the sodium channel Nav1.8 in the dorsal root ganglia (DRG), thereby reducing G-CSF-induced pain. JSHT had no effect on HSPC mobilization into the peripheral blood but might help regulate HSPC level within the bone marrow and potentially enhance HSPC function during G-CSF treatment. Additionally, JSHT effectively attenuated G-CSF-induced pain, suggesting its potential as a supportive therapy during G-CSF-induced stem cell mobilization.
SN  - 0263-6484
SN  - 1099-0844
ER  -