Prospects of pathogen whole-genome sequencing in outbreak tracing and antimicrobial resistance surveillance of spinal infections.
- 1Department of Orthopaedics, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, China.
- 2Department of Orthopaedics, The 961th Hospital of People's Liberation Army of China (PLA), Qiqihar, China.
Abstract
Spinal infections are a serious category of deep-seated infectious diseases that pose significant threats to human health. They are caused by a broad and complex spectrum of pathogens, including bacteria, fungi, and rare opportunistic organisms. Traditional diagnostic methods often face limitations in timeliness, accuracy, and source-tracing capability. Whole-genome sequencing (WGS), with its high resolution and throughput, provides comprehensive genetic information from pathogens, opening new avenues for precise diagnosis, outbreak tracing, and antimicrobial resistance monitoring and genomic epidemiology research in spinal infections., and enabling reliable identification of rare and fastidious pathogens that are difficult to characterize by conventional assays. This review systematically summarizes current applications of WGS in pathogen identification, clonal transmission inference, resistance gene and virulence factor analysis, and outbreak investigation. It further discusses the technical advantages, application challenges, and future development directions of WGS in outbreak tracing and resistance surveillance. Ultimately, this review aims to offer novel insights and a theoretical foundation for the precise prevention, control, and clinical management of spinal infections.
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BibTeX
@article{yu2026prospects,
title = {{Prospects of pathogen whole-genome sequencing in outbreak tracing and antimicrobial resistance surveillance of spinal infections.}},
author = {Xingsheng Yu and Zhen Jia and Jianhua Li and Zhaohu Mao and Zhengqi Chang},
journal = {Frontiers in cellular and infection microbiology},
year = {2026},
month = oct,
doi = {10.3389/fcimb.2026.1977484},
url = {https://europepmc.org/article/MED/42903328},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prospects of pathogen whole-genome sequencing in outbreak tracing and antimicrobial resistance surveillance of spinal infections.
AU - Xingsheng Yu
AU - Zhen Jia
AU - Jianhua Li
AU - Zhaohu Mao
AU - Zhengqi Chang
PY - 2026
DA - 2026/10/06
JO - Frontiers in cellular and infection microbiology
DO - 10.3389/fcimb.2026.1977484
UR - https://europepmc.org/article/MED/42903328
AB - Spinal infections are a serious category of deep-seated infectious diseases that pose significant threats to human health. They are caused by a broad and complex spectrum of pathogens, including bacteria, fungi, and rare opportunistic organisms. Traditional diagnostic methods often face limitations in timeliness, accuracy, and source-tracing capability. Whole-genome sequencing (WGS), with its high resolution and throughput, provides comprehensive genetic information from pathogens, opening new avenues for precise diagnosis, outbreak tracing, and antimicrobial resistance monitoring and genomic epidemiology research in spinal infections., and enabling reliable identification of rare and fastidious pathogens that are difficult to characterize by conventional assays. This review systematically summarizes current applications of WGS in pathogen identification, clonal transmission inference, resistance gene and virulence factor analysis, and outbreak investigation. It further discusses the technical advantages, application challenges, and future development directions of WGS in outbreak tracing and resistance surveillance. Ultimately, this review aims to offer novel insights and a theoretical foundation for the precise prevention, control, and clinical management of spinal infections.
SN - 2235-2988
ER -