The relationship between cardiometabolic disease and vertebral bone strength, mineral density, and mass in US…

Abstract

Context: Cardiometabolic disease (CMD) may increase vertebral fracture risk through deterioration in bone structure and/or tissue properties, compromising bone strength.

Objective: Evaluate the relationship between CMD and vertebral bone measures.

Design: Cross-sectional.

Participants: Coronary Artery Risk Development in Young Adults (CARDIA) study participants with year 25 (2010-2011) abdominal computed tomography (CT) scans (n = 2728).

Exposure: CMD (abdominal obesity, diabetes mellitus, dyslipidemia, or hypertension) status (≥1 vs 0) and burden (0, 1, 2, ≥3).

Outcome Measure(s): Vertebral strength, volumetric bone mineral density (vBMD), and bone mass, obtained via biomechanical CT analysis.

Methods: Multivariable linear regression evaluated the association between CMD and vertebral bone measures. Sex-specific models were adjusted for age, race, height, weight, and additional social determinants of health, lifestyle factors, and comorbidities. Effect modification by race, age, and menopausal status was evaluated.

Results: Overall, at least 1 CMD was identified in 72.3% of men and 70.5% of women. In the fully adjusted model, CMD status was significantly associated with lower total (β = −6.32 mg/cm3; P = .018), trabecular (β = −4.53 mg/cm3; P = .048), and cortical (β = −6.63 mg/cm3; P = .034) vBMD in men. Greater CMD burden was associated with lower total and trabecular vBMD. The negative association between CMD and vBMD was stronger in men ≤50 years. There was no association in women.

Conclusion: In this biracial cohort of Black and White adults from the United States, CMD was associated with significantly lower total and subcompartment vertebral vBMD in men.

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BibTeX RIS

BibTeX

@article{wright2026relationship,
  title = {{The relationship between cardiometabolic disease and vertebral bone strength, mineral density, and mass in US adults}},
  author = {Nicole C Wright and Rafeka Hossain and Mary L Bouxsein and Tony M Keaveny and David C Lee and Gerhard Hellemann and John Jeffrey Carr and James G Terry and Amy H Warriner and Cora E Lewis},
  journal = {Journal of the Endocrine Society},
  year = {2026},
  month = oct,
  doi = {10.1210/jendso/bvag193},
  url = {https://doi.org/10.1210/jendso/bvag193},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - The relationship between cardiometabolic disease and vertebral bone strength, mineral density, and mass in US adults
AU  - Nicole C Wright
AU  - Rafeka Hossain
AU  - Mary L Bouxsein
AU  - Tony M Keaveny
AU  - David C Lee
AU  - Gerhard Hellemann
AU  - John Jeffrey Carr
AU  - James G Terry
AU  - Amy H Warriner
AU  - Cora E Lewis
PY  - 2026
DA  - 2026/10/26
JO  - Journal of the Endocrine Society
DO  - 10.1210/jendso/bvag193
UR  - https://doi.org/10.1210/jendso/bvag193
AB  - Context: Cardiometabolic disease (CMD) may increase vertebral fracture risk through deterioration in bone structure and/or tissue properties, compromising bone strength.  Objective: Evaluate the relationship between CMD and vertebral bone measures.  Design: Cross-sectional.  Participants: Coronary Artery Risk Development in Young Adults (CARDIA) study participants with year 25 (2010-2011) abdominal computed tomography (CT) scans (n = 2728).  Exposure: CMD (abdominal obesity, diabetes mellitus, dyslipidemia, or hypertension) status (≥1 vs 0) and burden (0, 1, 2, ≥3).  Outcome Measure(s): Vertebral strength, volumetric bone mineral density (vBMD), and bone mass, obtained via biomechanical CT analysis.  Methods: Multivariable linear regression evaluated the association between CMD and vertebral bone measures. Sex-specific models were adjusted for age, race, height, weight, and additional social determinants of health, lifestyle factors, and comorbidities. Effect modification by race, age, and menopausal status was evaluated.  Results: Overall, at least 1 CMD was identified in 72.3% of men and 70.5% of women. In the fully adjusted model, CMD status was significantly associated with lower total (β = −6.32 mg/cm3; P = .018), trabecular (β = −4.53 mg/cm3; P = .048), and cortical (β = −6.63 mg/cm3; P = .034) vBMD in men. Greater CMD burden was associated with lower total and trabecular vBMD. The negative association between CMD and vBMD was stronger in men ≤50 years. There was no association in women.  Conclusion: In this biracial cohort of Black and White adults from the United States, CMD was associated with significantly lower total and subcompartment vertebral vBMD in men.
SN  - 2472-1972
ER  -

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