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Peer-reviewedCC BYClinics and practice

Association of Ultrafiltration Rate with Structural Remodeling of the Left Heart and Arrhythmias in Hemodialysis Patients: A Cross-Sectional Observational Study.

  • Ammar Brkić1
  • Kenana Ljuca2,3
  • Emir Tulumović4
  • Nadina Ljuca3
  • Nermin Salkić5
  • Emir Bećirović1
  • Amir Tursunović6
  • Minela Bećirović7
  • Bahrudin Hadžiefendić8
8 affiliations
  1. 1Department of Intensive Care, Clinic for Internal Medicine, University Clinical Center Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  2. 2Department of Gynecology and Obstetrics, University Clinical Center Ljubljana, 1000 Ljubljana, Slovenia.
  3. 3Department of Pharmacology, Faculty of Medicine, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  4. 4Department of Gastroenterology, Clinic for Internal Medicine, University Clinical Center Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  5. 5Erbe Elektromedizin GmbH, 72072 Tuebingen, Germany.
  6. 6Department of Surgery, University Clinical Center Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  7. 7Department of Nephrology and Hemodialysis, Clinic for Internal Medicine, University Clinical Center Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  8. 8Department of Surgery, Eurofarm Center Policlinic Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
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Abstract

Background/aim: Hemodialysis patients face a high burden of cardiovascular diseases, which account for over 40% of mortality in this population. In these patients, approximately two-thirds of cardiovascular deaths are due to arrhythmia. The aim of this study was to determine whether the ultrafiltration rate is associated with morphological and functional parameters of the left heart and arrhythmias. Methods: This work was a cross-sectional observational clinical study, with 75 hemodialysis patients. Patients were divided into two groups based on ultrafiltration rate (UFR): higher-UFR group, ultrafiltration rate ≥ 10 mL/kg/h (n = 37); lower-UFR group, ultrafiltration rate < 10 mL/kg/h (n = 38). All patients were analyzed for myocardial morphological and functional parameters and arrhythmias. Results: Statistically significant higher values were observed for the left atrium diameter (LAD) (47.56 ± 4.82 vs. 44.75 ± 2.33 mm, p = 0.0019), the left atrial volume index (LAVI) (43.28 ± 7.13 vs. 36.43 ± 8.52 mL/m², p = 0.0003), and the left ventricular mass index (LVMI) (138.47 ± 29.32 vs. 116.04 ± 31.64 g/m², p = 0.0021) in the higher-UFR group. UFR was associated with LAD (OR: 3.6000, 95% CI: 1.3780-9.4053, p = 0.0089), LAVI (OR: 4.1067, 95% CI: 1.5478-10.8956, p = 0.0045), and LVMI (OR: 4.7619, 95% CI: 1.6825-13.4774, p = 0.0033). The frequency of ventricular and supraventricular arrhythmias was similar between the analyzed patient groups. Conclusions: Higher UFR was associated with structural changes in the left heart (LAVI, LAD, and LVMI), but not with other echocardiographic parameters or arrhythmias in hemodialysis patients.

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Cite

BibTeXRIS
BibTeX
@article{brkic2026association,
  title = {{Association of Ultrafiltration Rate with Structural Remodeling of the Left Heart and Arrhythmias in Hemodialysis Patients: A Cross-Sectional Observational Study.}},
  author = {Ammar Brkić and Kenana Ljuca and Emir Tulumović and Nadina Ljuca and Nermin Salkić and Emir Bećirović and Amir Tursunović and Minela Bećirović and Bahrudin Hadžiefendić},
  journal = {Clinics and practice},
  year = {2026},
  month = sep,
  doi = {10.3390/clinpract16100182},
  url = {https://europepmc.org/article/MED/42930368},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association of Ultrafiltration Rate with Structural Remodeling of the Left Heart and Arrhythmias in Hemodialysis Patients: A Cross-Sectional Observational Study.
AU  - Ammar Brkić
AU  - Kenana Ljuca
AU  - Emir Tulumović
AU  - Nadina Ljuca
AU  - Nermin Salkić
AU  - Emir Bećirović
AU  - Amir Tursunović
AU  - Minela Bećirović
AU  - Bahrudin Hadžiefendić
PY  - 2026
DA  - 2026/09/30
JO  - Clinics and practice
DO  - 10.3390/clinpract16100182
UR  - https://europepmc.org/article/MED/42930368
AB  - Background/aim: Hemodialysis patients face a high burden of cardiovascular diseases, which account for over 40% of mortality in this population. In these patients, approximately two-thirds of cardiovascular deaths are due to arrhythmia. The aim of this study was to determine whether the ultrafiltration rate is associated with morphological and functional parameters of the left heart and arrhythmias. Methods: This work was a cross-sectional observational clinical study, with 75 hemodialysis patients. Patients were divided into two groups based on ultrafiltration rate (UFR): higher-UFR group, ultrafiltration rate ≥ 10 mL/kg/h (n = 37); lower-UFR group, ultrafiltration rate < 10 mL/kg/h (n = 38). All patients were analyzed for myocardial morphological and functional parameters and arrhythmias. Results: Statistically significant higher values were observed for the left atrium diameter (LAD) (47.56 ± 4.82 vs. 44.75 ± 2.33 mm, p = 0.0019), the left atrial volume index (LAVI) (43.28 ± 7.13 vs. 36.43 ± 8.52 mL/m², p = 0.0003), and the left ventricular mass index (LVMI) (138.47 ± 29.32 vs. 116.04 ± 31.64 g/m², p = 0.0021) in the higher-UFR group. UFR was associated with LAD (OR: 3.6000, 95% CI: 1.3780-9.4053, p = 0.0089), LAVI (OR: 4.1067, 95% CI: 1.5478-10.8956, p = 0.0045), and LVMI (OR: 4.7619, 95% CI: 1.6825-13.4774, p = 0.0033). The frequency of ventricular and supraventricular arrhythmias was similar between the analyzed patient groups. Conclusions: Higher UFR was associated with structural changes in the left heart (LAVI, LAD, and LVMI), but not with other echocardiographic parameters or arrhythmias in hemodialysis patients.
SN  - 2039-7275
SN  - 2039-7283
ER  -