Effects of Metabolic Pathways and Products on Early Mammalian Embryonic Development.
- 1Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province, Institute of Animal Sciences and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
- 2Animal Science Institute, Guangxi University, Nanning 530005, China.
- 3Guangdong Provincial Engineering and Technology Research Center for Gene Editing, School of Medical Engineering, Foshan University, Foshan 528225, China.
Abstract
Background
The study of early mammalian embryonic development is the basis for the cultivation of embryonic stem cells (ESCs), assisted reproductive technology (ART), and understanding and preventing early embryonic developmental defects. Metabolism is the most fundamental physiological activity of embryonic development. Studies have shown that specific metabolic pathways and metabolites play key roles in embryonic development. These roles involve the regulation of signal transduction in addition to the provision of energy to the organism.Aim of review
This review examines the factors affecting the critical moments of embryonic development, such as oocyte maturation, zygotic gene activation, cell compaction, and two genealogical differentiations. It also presents the characteristics of embryonic metabolism at this time. This review aims to provide new insights and approaches for improving early mammalian embryonic development by clarifying the relationship between embryonic metabolism and its developmental processes. Furthermore, the review emphasizes embryonic metabolism as a potential indicator for assessing the level of embryonic development in vitro, providing a new basis for assessment in assisted reproductive technologies. Key Scientific Concepts of Review: This review is focused on three main key concepts. First, we demonstrate known regulatory mechanisms of embryonic development to enhance the potential of early embryonic development. Second, we elucidate the potential role of metabolic processes and their products in early embryonic development. Third, we provide new foundations and perspectives for the study of the early embryo from the perspective of cellular metabolism.
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BibTeX
@article{tao2026effects,
title = {{Effects of Metabolic Pathways and Products on Early Mammalian Embryonic Development.}},
author = {Hu Tao and Zaidong Hua and Jingwei Wei and Xiangxing Zhu and Qi Xiong},
journal = {Cells},
year = {2026},
month = oct,
doi = {10.3390/cells15191808},
url = {https://europepmc.org/article/MED/42882507},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of Metabolic Pathways and Products on Early Mammalian Embryonic Development.
AU - Hu Tao
AU - Zaidong Hua
AU - Jingwei Wei
AU - Xiangxing Zhu
AU - Qi Xiong
PY - 2026
DA - 2026/10/03
JO - Cells
DO - 10.3390/cells15191808
UR - https://europepmc.org/article/MED/42882507
AB - Background The study of early mammalian embryonic development is the basis for the cultivation of embryonic stem cells (ESCs), assisted reproductive technology (ART), and understanding and preventing early embryonic developmental defects. Metabolism is the most fundamental physiological activity of embryonic development. Studies have shown that specific metabolic pathways and metabolites play key roles in embryonic development. These roles involve the regulation of signal transduction in addition to the provision of energy to the organism.Aim of review This review examines the factors affecting the critical moments of embryonic development, such as oocyte maturation, zygotic gene activation, cell compaction, and two genealogical differentiations. It also presents the characteristics of embryonic metabolism at this time. This review aims to provide new insights and approaches for improving early mammalian embryonic development by clarifying the relationship between embryonic metabolism and its developmental processes. Furthermore, the review emphasizes embryonic metabolism as a potential indicator for assessing the level of embryonic development in vitro, providing a new basis for assessment in assisted reproductive technologies. Key Scientific Concepts of Review: This review is focused on three main key concepts. First, we demonstrate known regulatory mechanisms of embryonic development to enhance the potential of early embryonic development. Second, we elucidate the potential role of metabolic processes and their products in early embryonic development. Third, we provide new foundations and perspectives for the study of the early embryo from the perspective of cellular metabolism.
SN - 2073-4409
ER -