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Peer-reviewedCC BY-NC 4.0Multidisciplinary Respiratory Medicine

Tracking severe asthma improvement with biologic therapy using spirometry and impulse oscillometry: A real-world study

  • Alessandra Chiei Gallo1
  • Laura Ventura2
  • Lea Caron1
  • Marta Guglieri1
  • Eleonora Bono1
  • Enrico Iemoli1
  • Giovanna Elisiana Carpagnano3
  • Andrea Portacci3
  • Francesco Tursi4
  • Valeria Ortolani1
4 affiliations
  1. 1Allergy and Clinical Immunology Unit, L. Sacco Hospital, Milan, Italy
  2. 2Department of Statistical Sciences, University of Padua, Padua, Italy
  3. 3Institute of Respiratory Disease, Department of Translational Biomedicine and neuroscience, University “Aldo Moro”, Bari, Italy
  4. 4UOC Riabilitazione Specialistica Cardiorespiratoria, Codogno Hospital, ASST Lodi, Lodi, Italy
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Abstract

Background: Severe asthma patients receiving biologic therapy require accurate functional assessment and longitudinal monitoring. Spirometry and impulse oscillometry (IOS) may provide complementary information on lung function. The aim of this study was to compare spirometry and IOS in severe asthma patients treated with biologics, evaluating their concordance and clinical relevance, and to assess longitudinal changes in asthma control, oral corticosteroid (OCS) use, exacerbations, and healthcare utilization over 18 months.

Methods: In this real-world dual-centre longitudinal study, 40 patients with severe asthma treated with biologic therapy underwent spirometry and IOS at baseline and after 6, 12, and 18 months. Functional findings were compared between the two techniques and correlated with asthma control, OCS use, exacerbations, hospitalizations, and healthcare utilization.

Results: Significant clinical improvement was observed over 18 months, with reductions in exacerbations, hospitalizations, healthcare utilization and OCS use, alongside improved ACT scores. FEF25–75% showed partial functional improvement and significant correlations with IOS indices, particularly R5–R20 (r=−0.52 to −0.65) and AX (r=−0.30 to −0.54), supporting the complementary role of oscillometry in longitudinal assessment.

Conclusions: Biologic therapy significantly reduced the clinical burden of severe asthma. IOS may provide complementary information alongside spirometry for longitudinal functional monitoring in real-life setting.

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Cite

BibTeXRIS
BibTeX
@article{gallo2026tracking,
  title = {{Tracking severe asthma improvement with biologic therapy using spirometry and impulse oscillometry: A real-world study}},
  author = {Alessandra Chiei Gallo and Laura Ventura and Lea Caron and Marta Guglieri and Eleonora Bono and Enrico Iemoli and Giovanna Elisiana Carpagnano and Andrea Portacci and Francesco Tursi and Valeria Ortolani},
  journal = {Multidisciplinary Respiratory Medicine},
  year = {2026},
  month = oct,
  doi = {10.5826/mrm.2026.1142},
  url = {https://doi.org/10.5826/mrm.2026.1142},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Tracking severe asthma improvement with biologic therapy using spirometry and impulse oscillometry: A real-world study
AU  - Alessandra Chiei Gallo
AU  - Laura Ventura
AU  - Lea Caron
AU  - Marta Guglieri
AU  - Eleonora Bono
AU  - Enrico Iemoli
AU  - Giovanna Elisiana Carpagnano
AU  - Andrea Portacci
AU  - Francesco Tursi
AU  - Valeria Ortolani
PY  - 2026
DA  - 2026/10/22
JO  - Multidisciplinary Respiratory Medicine
DO  - 10.5826/mrm.2026.1142
UR  - https://doi.org/10.5826/mrm.2026.1142
AB  - Background: Severe asthma patients receiving biologic therapy require accurate functional assessment and longitudinal monitoring. Spirometry and impulse oscillometry (IOS) may provide complementary information on lung function. The aim of this study was to compare spirometry and IOS in severe asthma patients treated with biologics, evaluating their concordance and clinical relevance, and to assess longitudinal changes in asthma control, oral corticosteroid (OCS) use, exacerbations, and healthcare utilization over 18 months.  Methods: In this real-world dual-centre longitudinal study, 40 patients with severe asthma treated with biologic therapy underwent spirometry and IOS at baseline and after 6, 12, and 18 months. Functional findings were compared between the two techniques and correlated with asthma control, OCS use, exacerbations, hospitalizations, and healthcare utilization.  Results: Significant clinical improvement was observed over 18 months, with reductions in exacerbations, hospitalizations, healthcare utilization and OCS use, alongside improved ACT scores. FEF25–75% showed partial functional improvement and significant correlations with IOS indices, particularly R5–R20 (r=−0.52 to −0.65) and AX (r=−0.30 to −0.54), supporting the complementary role of oscillometry in longitudinal assessment.  Conclusions: Biologic therapy significantly reduced the clinical burden of severe asthma. IOS may provide complementary information alongside spirometry for longitudinal functional monitoring in real-life setting.
SN  - 1828-695X
SN  - 2049-6958
ER  -