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Peer-reviewedCC BYMRS communications

Cellularized, needle-deployed intracortical arrays for brain electrophysiology.

  • Alexander J Boys1,2
  • Alejandro Carnicer Lombarte3,4
  • Salim El-Hadwe3,5
  • Sam Hilton3
  • Chaeyeon Lee3
  • Filip Wronowski3
  • Tobias E Naegele3
  • Ana Fernandez-Villegas1
  • Damiano G Barone3,5,6,7
  • Gabriele S Kaminski Scherle1
  • George G Malliaras3
7 affiliations
  1. 1Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, CB1 0AS UK.
  2. 2Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA.
  3. 3Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ UK.
  4. 4Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong China.
  5. 5Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ UK.
  6. 6Department of Neurosurgery, Houston Methodist, Houston, TX 77030 USA.
  7. 7Neuroengineering Initiative, Rice University, Houston, TX 77030 USA.
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Abstract

Bioelectronic medicine enables direct interfacing with native cell populations but remains limited by poor long-term integration and minimal interaction with non-electroactive cells. In contrast, regenerative medicine promotes tissue integration yet lacks bidirectional functionality. Here, we present a hybrid implantation methodology combining a tissue engineered cellularized hydrogel with a neural recording array for simultaneous delivery into the brain via needle placement. This approach enables co-localized transplantation of cells and electronics while minimizing surgical footprint. Post-implantation electrophysiological recordings show functional integration with surrounding neural tissue, demonstrating the feasibility of this platform for coupled bioelectronic sensing and regenerative capabilities. The online version contains supplementary material available at https://doi.org/10.1557/s43579-026-01033-7.

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Cite

BibTeXRIS
BibTeX
@article{boys2026cellularized,
  title = {{Cellularized, needle-deployed intracortical arrays for brain electrophysiology.}},
  author = {Alexander J Boys and Alejandro Carnicer Lombarte and Salim El-Hadwe and Sam Hilton and Chaeyeon Lee and Filip Wronowski and Tobias E Naegele and Ana Fernandez-Villegas and Damiano G Barone and Gabriele S Kaminski Scherle and George G Malliaras},
  journal = {MRS communications},
  year = {2026},
  month = aug,
  doi = {10.1557/s43579-026-01033-7},
  url = {https://europepmc.org/article/MED/42999435},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Cellularized, needle-deployed intracortical arrays for brain electrophysiology.
AU  - Alexander J Boys
AU  - Alejandro Carnicer Lombarte
AU  - Salim El-Hadwe
AU  - Sam Hilton
AU  - Chaeyeon Lee
AU  - Filip Wronowski
AU  - Tobias E Naegele
AU  - Ana Fernandez-Villegas
AU  - Damiano G Barone
AU  - Gabriele S Kaminski Scherle
AU  - George G Malliaras
PY  - 2026
DA  - 2026/08/19
JO  - MRS communications
DO  - 10.1557/s43579-026-01033-7
UR  - https://europepmc.org/article/MED/42999435
AB  - Bioelectronic medicine enables direct interfacing with native cell populations but remains limited by poor long-term integration and minimal interaction with non-electroactive cells. In contrast, regenerative medicine promotes tissue integration yet lacks bidirectional functionality. Here, we present a hybrid implantation methodology combining a tissue engineered cellularized hydrogel with a neural recording array for simultaneous delivery into the brain via needle placement. This approach enables co-localized transplantation of cells and electronics while minimizing surgical footprint. Post-implantation electrophysiological recordings show functional integration with surrounding neural tissue, demonstrating the feasibility of this platform for coupled bioelectronic sensing and regenerative capabilities. The online version contains supplementary material available at https://doi.org/10.1557/s43579-026-01033-7.
SN  - 2159-6859
SN  - 2159-6867
ER  -