Global Trends and Evidence Mapping of Rice Allergen Research (Oryza sativa): A Bibliometric and Systematic Scoping Review of Allergenic Proteins, IgE Reactivity, Food Safety Detection, and Hypoallergenic Rice Development
5 affiliations
- 1Department of Pharmacy, Faculty of Medicine & Health Sciences, Universitas Alma Ata, Yogyakarta, Indonesia
- 2Department of Oncology Nursing, Faculty of Nursing, Universitas Indonesia, Indonesia
- 3Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia
- 4Department of Chemistry, Faculty of Mathematics and Natural Science, Lambung Mangkurat University, Indonesia
- 5Department of Nursing, Faculty of Health Science, Alma Ata University, Yogyakarta, Indonesia
Abstract
Background: Rice (Oryza sativa) is a staple food and perceived as relatively hypoallergenic. However, rice has been implicated in food protein-induced enterocolitis syndrome, IgE-mediated allergy, sensitization, anaphylaxis, and product-related allergenicity. Objective: This study mapped global publication trends charted evidence themes in rice allergen research, with emphasis on allergenic proteins, IgE reactivity, analytical detection, food safety, processing-related allergenicity, and hypoallergenic rice or rice-based product development. Methods: Bibliometric analysis was combined with a systematic scoping review and evidence mapping. Scopus and PubMed/MEDLINE were searched without language or lower publication-year restrictions for original research published through 2025. All eligible records from both databases contributed to the systematic scoping review, while eligible Scopus-indexed records formed the bibliometric subset. Bibliometrix and VOSviewer were used for bibliometric and network analyses, while evidence was charted using a PCC and PRISMA-ScR-informed framework. Results: Of 1,405 records identified, 927 unique records entered screening and 363 original studies were included in the systematic scoping review; 351 Scopus-indexed studies formed the bibliometric subset. The bibliometric subset spanned 1969–2025 and 193 harmonized journal sources. Evidence was mapped to five non-exclusive domains: clinical phenotypes (T1), rice allergenic proteins and molecular characterization (T2), immune reactivity and cross-reactivity (T3), analytical/diagnostic/safety-assessment methods (T4), and translational products or processing approaches (T5). Conclusion: Rice allergen research spans multiple but incompletely integrated evidence domains. Future studies should connect clinical phenotypes, validated allergenic proteins, food matrices, processing conditions, patient sera, analytical platforms, and real-world rice products to support safer rice-based food development.
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BibTeX
@article{santoso2026global,
title = {{Global Trends and Evidence Mapping of Rice Allergen Research (Oryza sativa): A Bibliometric and Systematic Scoping Review of Allergenic Proteins, IgE Reactivity, Food Safety Detection, and Hypoallergenic Rice Development}},
author = {Bayu Bakti Santoso and Dina Elisyabanniah and Danang Amukti and Muhammad Novrizal Sahid and Uripto Santoso and Riko Aditya and Imam Akbar},
journal = {Bulletin of Pharmaceutical Sciences. Assiut University},
year = {2026},
month = oct,
doi = {10.21608/bfsa.2026.511967.3221},
url = {https://doi.org/10.21608/bfsa.2026.511967.3221},
note = {CC BY},
}
RIS
TY - JOUR
TI - Global Trends and Evidence Mapping of Rice Allergen Research (Oryza sativa): A Bibliometric and Systematic Scoping Review of Allergenic Proteins, IgE Reactivity, Food Safety Detection, and Hypoallergenic Rice Development
AU - Bayu Bakti Santoso
AU - Dina Elisyabanniah
AU - Danang Amukti
AU - Muhammad Novrizal Sahid
AU - Uripto Santoso
AU - Riko Aditya
AU - Imam Akbar
PY - 2026
DA - 2026/10/25
JO - Bulletin of Pharmaceutical Sciences. Assiut University
DO - 10.21608/bfsa.2026.511967.3221
UR - https://doi.org/10.21608/bfsa.2026.511967.3221
AB - Background: Rice (Oryza sativa) is a staple food and perceived as relatively hypoallergenic. However, rice has been implicated in food protein-induced enterocolitis syndrome, IgE-mediated allergy, sensitization, anaphylaxis, and product-related allergenicity. Objective: This study mapped global publication trends charted evidence themes in rice allergen research, with emphasis on allergenic proteins, IgE reactivity, analytical detection, food safety, processing-related allergenicity, and hypoallergenic rice or rice-based product development. Methods: Bibliometric analysis was combined with a systematic scoping review and evidence mapping. Scopus and PubMed/MEDLINE were searched without language or lower publication-year restrictions for original research published through 2025. All eligible records from both databases contributed to the systematic scoping review, while eligible Scopus-indexed records formed the bibliometric subset. Bibliometrix and VOSviewer were used for bibliometric and network analyses, while evidence was charted using a PCC and PRISMA-ScR-informed framework. Results: Of 1,405 records identified, 927 unique records entered screening and 363 original studies were included in the systematic scoping review; 351 Scopus-indexed studies formed the bibliometric subset. The bibliometric subset spanned 1969–2025 and 193 harmonized journal sources. Evidence was mapped to five non-exclusive domains: clinical phenotypes (T1), rice allergenic proteins and molecular characterization (T2), immune reactivity and cross-reactivity (T3), analytical/diagnostic/safety-assessment methods (T4), and translational products or processing approaches (T5). Conclusion: Rice allergen research spans multiple but incompletely integrated evidence domains. Future studies should connect clinical phenotypes, validated allergenic proteins, food matrices, processing conditions, patient sera, analytical platforms, and real-world rice products to support safer rice-based food development.
SN - 3009-7703
SN - 1110-0052
ER -