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PreprintCC BY-NC-ND 4.0ChemRxiv

Hybrid Photoactive Lignin Based Magnetic Nanomaterials for Antimicrobial Application

  • Emma Robbins1
  • Yann Berbiguier2
  • Hong-Tao Ji1
  • Emilie Genin1
  • Claire Carrion3
  • Claude A. Calliste4
  • Léa Gibot-Leclerc4
  • Christelle Gady2
  • Nicolas Villandier2
  • Stéphanie Leroy-Lhez2
  • Karine Heuzé1
4 affiliations
  1. 1Univ. Bordeaux, CNRS, Bordeaux INP
  2. 2Faculté des Sciences et Techniques, Université de Limoges, 123 Avenue Albert Thomas, Limoges, France, 87060
  3. 3BISCEm, US 42, Limoges, France, F-87000
  4. 4Faculté de Pharmacie, Université de Limoges, 2 Rue du Dr. Raymond Marcland, Limoges Cedex, France, 87060
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Abstract

The rise of antimicrobial resistance (AMR) necessitates the development of sustainable and efficient alternatives to traditional antibiotics. Here, we report the design and characterization of hybrid photoactive nanomaterials composed of porphyrin-functionalized magnetic nanoparticles (MNPs) embedded in an acetylated lignin (AcLi) matrix. These materials leverage the photodynamic properties of porphyrins to generate reactive oxygen species (ROS), particularly singlet oxygen (¹O₂), under light irradiation, enabling their use in Photodynamic Antimicrobial Chemotherapy (PACT). The core-shell (γ-Fe₂O₃ - SiO₂) MNPs, were functionalized with azide (N₃) or aldehyde (CHO) groups to covalently graft alkyne- or amino-substituted porphyrins via click chemistry or reductive amination. The resulting hybrid materials (MNP@N3@Porph, MNP@CHO@Porph, and MNP@N3@Lignol) were thoroughly characterized using HR-TEM, UV-Vis, fluorescence spectroscopy, and EPR, confirming the successful immobilization of porphyrins and their ability to produce ¹O₂. Biological validation against Staphylococcus aureus demonstrated the spontaneous interaction of the nanoparticles with bacterial cells, a critical feature for PACT efficacy. Additionally, the magnetic properties of the MNPs enable easy recovery and recyclability, addressing a key challenge in photocatalytic systems.

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Cite

BibTeXRIS
BibTeX
@misc{robbins2026hybrid,
  title = {{Hybrid Photoactive Lignin Based Magnetic Nanomaterials for Antimicrobial Application}},
  author = {Emma Robbins and Yann Berbiguier and Hong-Tao Ji and Emilie Genin and Claire Carrion and Claude A. Calliste and Léa Gibot-Leclerc and Christelle Gady and Nicolas Villandier and Stéphanie Leroy-Lhez and Karine Heuzé},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010523/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010523/v1},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - UNPB
TI  - Hybrid Photoactive Lignin Based Magnetic Nanomaterials for Antimicrobial Application
AU  - Emma Robbins
AU  - Yann Berbiguier
AU  - Hong-Tao Ji
AU  - Emilie Genin
AU  - Claire Carrion
AU  - Claude A. Calliste
AU  - Léa Gibot-Leclerc
AU  - Christelle Gady
AU  - Nicolas Villandier
AU  - Stéphanie Leroy-Lhez
AU  - Karine Heuzé
PY  - 2026
DA  - 2026/10/15
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010523/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010523/v1
AB  - The rise of antimicrobial resistance (AMR) necessitates the development of sustainable and efficient alternatives to traditional antibiotics. Here, we report the design and characterization of hybrid photoactive nanomaterials composed of porphyrin-functionalized magnetic nanoparticles (MNPs) embedded in an acetylated lignin (AcLi) matrix. These materials leverage the photodynamic properties of porphyrins to generate reactive oxygen species (ROS), particularly singlet oxygen (¹O₂), under light irradiation, enabling their use in Photodynamic Antimicrobial Chemotherapy (PACT). The core-shell (γ-Fe₂O₃ - SiO₂) MNPs, were functionalized with azide (N₃) or aldehyde (CHO) groups to covalently graft alkyne- or amino-substituted porphyrins via click chemistry or reductive amination. The resulting hybrid materials (MNP@N3@Porph, MNP@CHO@Porph, and MNP@N3@Lignol) were thoroughly characterized using HR-TEM, UV-Vis, fluorescence spectroscopy, and EPR, confirming the successful immobilization of porphyrins and their ability to produce ¹O₂. Biological validation against Staphylococcus aureus demonstrated the spontaneous interaction of the nanoparticles with bacterial cells, a critical feature for PACT efficacy. Additionally, the magnetic properties of the MNPs enable easy recovery and recyclability, addressing a key challenge in photocatalytic systems.
ER  -