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Peer-reviewedCC BY-NC 4.0Journal of Breast Cancer

Primary Breast Pure Metaplastic Squamous Cell Carcinoma: A Breast Abscess With Squamous Metaplasia and Malignant Transformation That Mimics Condylomata Acuminata

  • Jing Wen Loh1,2
  • Ai Chen Chan2
  • Abdul Kadir Rifaei Abd Rashid Khairi3
  • Najihah Abu Bakar4
4 affiliations
  1. 1Department of Surgery, Hospital Teluk Intan, Teluk Intan, Malaysia .
  2. 2Breast and Endocrine Surgery Unit, Department of Surgery, Hospital Raja Permaisuri Bainun, Ipoh, Malaysia .
  3. 3Department of Pathology, Hospital Teluk Intan, Teluk Intan, Malaysia .
  4. 4Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia .
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Abstract

Pure metaplastic squamous cell carcinomas (MSCC) of the breast are rare. We report the case of a 57-year-old woman who presented with a breast abscess in whom a papillomatous lesion was identified during incision and drainage. The initial biopsy demonstrated hyperplastic squamous epithelium with koilocytic atypia, raising the possibility of condylomata acuminata. Subsequent wide excision revealed extensive squamous metaplasia with invasive squamous cell carcinoma arising within a cystic papillary lesion consistent with pure MSCC of the breast. Immunohistochemistry revealed positivity for p63 and negativity for p16, estrogen receptor, progesterone receptor, and human epidermal growth receptor 2. The investigations excluded human papillomavirus infections, cutaneous origins, and extramammary primary squamous cell carcinomas. Following early local recurrence, the patient underwent mastectomy and axillary dissection. Adjuvant radiotherapy and chemotherapy were also administered. This case highlights the diagnostic challenges and aggressive behavior of pure MSCC and emphasizes the importance of clinicopathological correlations and multidisciplinary management.

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Cite

BibTeXRIS
BibTeX
@article{loh2026primary,
  title = {{Primary Breast Pure Metaplastic Squamous Cell Carcinoma: A Breast Abscess With Squamous Metaplasia and Malignant Transformation That Mimics Condylomata Acuminata}},
  author = {Jing Wen Loh and Ai Chen Chan and Abdul Kadir Rifaei Abd Rashid Khairi and Najihah Abu Bakar},
  journal = {Journal of Breast Cancer},
  year = {2026},
  month = sep,
  doi = {10.4048/jbc.2026.0091},
  url = {https://doi.org/10.4048/jbc.2026.0091},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Primary Breast Pure Metaplastic Squamous Cell Carcinoma: A Breast Abscess With Squamous Metaplasia and Malignant Transformation That Mimics Condylomata Acuminata
AU  - Jing Wen Loh
AU  - Ai Chen Chan
AU  - Abdul Kadir Rifaei Abd Rashid Khairi
AU  - Najihah Abu Bakar
PY  - 2026
DA  - 2026/09/11
JO  - Journal of Breast Cancer
DO  - 10.4048/jbc.2026.0091
UR  - https://doi.org/10.4048/jbc.2026.0091
AB  - Pure metaplastic squamous cell carcinomas (MSCC) of the breast are rare. We report the case of a 57-year-old woman who presented with a breast abscess in whom a papillomatous lesion was identified during incision and drainage. The initial biopsy demonstrated hyperplastic squamous epithelium with koilocytic atypia, raising the possibility of condylomata acuminata. Subsequent wide excision revealed extensive squamous metaplasia with invasive squamous cell carcinoma arising within a cystic papillary lesion consistent with pure MSCC of the breast. Immunohistochemistry revealed positivity for p63 and negativity for p16, estrogen receptor, progesterone receptor, and human epidermal growth receptor 2. The investigations excluded human papillomavirus infections, cutaneous origins, and extramammary primary squamous cell carcinomas. Following early local recurrence, the patient underwent mastectomy and axillary dissection. Adjuvant radiotherapy and chemotherapy were also administered. This case highlights the diagnostic challenges and aggressive behavior of pure MSCC and emphasizes the importance of clinicopathological correlations and multidisciplinary management.
SN  - 1738-6756
SN  - 2092-9900
ER  -